Article (Scientific journals)
Effects of betamethasone on inflammation and emphysema induced by cadmium nebulisation in rats
Fievez, Laurence; Kirschvink, N.; Zhang, Wenhui H. et al.
2009In European Journal of Pharmacology, 606 (1-3), p. 210-214
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Keywords :
Cadmium; Emphysema; Glucocorticoid; Inflammation
Abstract :
[en] Cadmium (Cd) induces centrilobular emphysema and is suspected to contribute to tobacco related lung diseases as chronic obstructive pulmonary disease (COPD). This study aimed to check whether the inflammatory process observed in rats exposed to nebulised Cd is resistant to betamethasone as observed in COPD and to determine the influence of this drug on airspace enlargement together with the MMP-2-9/TIMP-1-2 imbalance. Our results showed that betamethasone induced emphysema by itself in healthy rats. Moreover, pre-treatment of rats with betamethasone could only partially modulate the increase in bronchoalveolar lavage fluid cell counts and the absence of preventive effect of this compound against emphysema development is associated with its inability to rebalance the MMP-2-9/TIMP-1-2 ratio.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Fievez, Laurence ;  Université de Liège - ULiège > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire
Kirschvink, N.
Zhang, Wenhui H.
Lagente, Vincent
Lekeux, Pierre ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie - Doyen de la Faculté de Médecine vétérinaire
Bureau, Fabrice ;  Université de Liège - ULiège > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire
Gustin, Pascal ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie
Language :
English
Title :
Effects of betamethasone on inflammation and emphysema induced by cadmium nebulisation in rats
Publication date :
2009
Journal title :
European Journal of Pharmacology
ISSN :
0014-2999
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
606
Issue :
1-3
Pages :
210-214
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 10 March 2009

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