Keywords :
Peptidase; Bacteria; Actinomycetes; Actinomycetales; Streptomycetaceae; Enzyme; Streptomyces; Column chromatography; Radiolabelling; N terminal-Sequence; Active site; Penicillin; Binding protein; Protéine de liaison; Bactérie; Chromatographie colonne; Marquage radioisotopique; Séquence N terminale; Site actif; Pénicilline; Proteina de enlace; Enzima; Cromatografía columna; Marcación radioisotópica; Secuencia N terminal; Lugar activo
Abstract :
[en] The N-terminal region of the Streptomyces K15 DD-peptidase/penicillin-binding protein shows high homology with that of other penicillin-interactive proteins or domains. The active-site serine residue of the conserved tetrad Ser-Xaa-Xaa-Lys occurs at position 35. There is no indication for the presence of a signal peptide or an N-terminal hydrophobic sequence, suggesting that the Streptomyces K15 enzyme is probably anchored to the membrane by a C-terminal peptide segment.
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