Reference : Effect of chronic airway inflammation and exercise on pulmonary and systemic antioxid...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/81277
Effect of chronic airway inflammation and exercise on pulmonary and systemic antioxidant status of healthy and heaves-affected horses
English
Kirschvink, Nathalie [Université de Liège - ULiège > > > > > >]
Smith, N. [Centre for Equine Studies, Animal Health Trust, Newmarket, UK > > > > > >]
Fievez, Laurence mailto [Université de Liège - ULiège > Département de sciences fonctionnelles > Biochimie et biologie moléculaire >]
Bougnet, V. [Université de Liège - ULiège > > > > > >]
Art, Tatiana mailto [Université de Liège - ULiège > Département de sciences fonctionnelles > Phys. neuro-muscul., de l'effort - Méd. sport. des animaux >]
Degand, Guy mailto [Université de Liège - ULiège > Département de sciences des denrées alimentaires > Analyse des denrées alimentaires >]
Marlin, D. [Centre for Equine Studies, Animal Health Trust, Newmarket, UK > > > > > >]
Roberts, C. [Centre for Equine Studies, Animal Health Trust, Newmarket, UK > > > > > >]
Genicot, B. [Biostatistics, Limburgs Universitair Centrum, Diepenbeek, Belgium > > > > > >]
Lindsey, P. [Biostatistics, Limburgs Universitair Centrum, Diepenbeek, Belgium > > > > > >]
Lekeux, Pierre mailto [Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie >]
2002
Equine Veterinary Journal
Equine Veterinary Journal Ltd
34
6
563-571
Yes (verified by ORBi)
International
0425-1644
Newmarket
England
[en] horse ; glutathione ; uric acid ; 8-epi-PGF(2 alpha) ; airway inflammation ; exercise ; heaves
[en] In heaves-affected horses the relation between oxidant status, airway inflammation (AI) and pulmonary function (PF) is unknown. The oxidant status of blood and pulmonary epithelial lining fluid (PELF) of healthy (H, n = 6) and heaves-affected horses in clinical remission (REM, n = 6) and in crisis (CR, n = 7) was assessed at rest, during and after standardised exercise test by measurement of reduced and oxidised glutathione, glutathione redox ratio [GRR%]; uric acid and 8-epi-PGF2alpha. Oxidant status was related to PF parameters (mechanics of breathing and arterial blood gas tension) and Al parameters (bronchoalveolar lavage [BAL] neutrophil % and AI score). Haemolysate glutathione was significantly different between groups and was correlated with PF and AI parameters; GRR in PELF was increased during CR and was correlated with PF and AI parameters. Exercise induced an increase of plasma uric acid that was significantly higher both in REM and CR. PELF 8-epi-PGF2alpha was significantly increased in CR and correlated with PF and AI parameters. These results suggest that oxidative stress occurring in heaves is correlated with PF and AI and may be locally assessed by PELF glutathione status, uric acid and 8-epi-PGF2alpha. Systemic repercussions are reflected by assay of GSH in resting horses and by uric acid in exercising horses.
Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA & grants from the Home of Rest of Horses, United Kingdom and Equine Research Funds, Belgium
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/81277
10.2746/042516402776180223

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
KirschvinkN_EquineVetJ_2002_EffectofChronic.pdfPublisher postprint97.71 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.