Phenotype of thymic lymphomas in the mouse.

Animals; Antibodies, Monoclonal/diagnostic use; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface/analysis; Cell Differentiation; Flow Cytometry; Lymphoma/immunology/pathology; Mice; Phenotype; T-Lymphocytes/immunology/pathology; Thymus Neoplasms/immunology/pathology

Abstract :

[en] The MP2 cell line was established from a murine leukemia virus-induced thymic lymphoma. Half of the cells were consistently L3T4 positive and less than 5% of the cells were Lyt-2 positive. Single cell cloning on the basis of the presence or absence of Lyt-2 allowed the isolation of four clones with stable phenotypes: (1) Lyt-2-, L3T4-; (2) Lyt-2+, L3T4+; (3) Lyt-2-, L3T4+; (4) Lyt2+, L3T4-. These data are discussed in relation to tumour cell heterogeneity and to normal T-cell differentiation pathways.

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology

Author, co-author :

Greimers, Roland ; Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique

Rongy, Anne Michel

Defresne, Marie-Paule ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie

Boniver, Jacques ; Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique

Hooghe, Robert

Language :

English

Title :

Phenotype of thymic lymphomas in the mouse.

Publication date :

1986

Journal title :

Leukemia Research

ISSN :

0145-2126

Publisher :

Pergamon Press - An Imprint of Elsevier Science

Volume :

Issue :

Pages :

777-82

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

FRSM - Fonds de la Recherche Scientifique Médicale
CAC - Centre anticancéreux près l'Université de Liège asbl
Radiation Protection Programme of the European Communities
European Late Effects Project Group

Available on ORBi :

since 19 November 2010

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