Article (Scientific journals)
Phenotype of thymic lymphomas in the mouse.
Greimers, Roland; Rongy, Anne Michel; Defresne, Marie-Paule et al.
1986In Leukemia Research, 10 (7), p. 777-82
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Keywords :
Animals; Antibodies, Monoclonal/diagnostic use; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface/analysis; Cell Differentiation; Flow Cytometry; Lymphoma/immunology/pathology; Mice; Phenotype; T-Lymphocytes/immunology/pathology; Thymus Neoplasms/immunology/pathology
Abstract :
[en] The MP2 cell line was established from a murine leukemia virus-induced thymic lymphoma. Half of the cells were consistently L3T4 positive and less than 5% of the cells were Lyt-2 positive. Single cell cloning on the basis of the presence or absence of Lyt-2 allowed the isolation of four clones with stable phenotypes: (1) Lyt-2-, L3T4-; (2) Lyt-2+, L3T4+; (3) Lyt-2-, L3T4+; (4) Lyt2+, L3T4-. These data are discussed in relation to tumour cell heterogeneity and to normal T-cell differentiation pathways.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Greimers, Roland ;  Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
Rongy, Anne Michel
Defresne, Marie-Paule ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Boniver, Jacques ;  Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
Hooghe, Robert
Language :
English
Title :
Phenotype of thymic lymphomas in the mouse.
Publication date :
1986
Journal title :
Leukemia Research
ISSN :
0145-2126
Publisher :
Pergamon Press - An Imprint of Elsevier Science
Volume :
10
Issue :
7
Pages :
777-82
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FRSM - Fonds de la Recherche Scientifique Médicale [BE]
CAC - Centre anticancéreux près l'Université de Liège asbl [BE]
Radiation Protection Programme of the European Communities
European Late Effects Project Group
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