self-assembly in solution; micelle; Nuclear Magnetic Resonance Imaging (MRI) contrast agent
Abstract :
[en] New micellar macrocontrast agents with improved contrast at high frequencies were designed by grafting a gadolinium based contrast agent onto functional stealth micelles formed by poly(ethylene oxide)-b-poly(ε-caprolactone) (PEO-b-PCL) in water. As evidenced by relaxometry measurements and the hemolytic CH50 test, the new contrast agents are of interest as MRI blood pool agents.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry Materials science & engineering
Author, co-author :
Grogna, Mathurin ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Cloots, Rudi ; Université de Liège - ULiège > Department of Chemistry > Laboratory of Structural Inorganic Chemistry
Luxen, André ; Université de Liège - ULiège > Department of Chemistry > Cyclotron Research Center
Jérôme, Christine ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Passirani, Catherine; INSERM, U 646, Angers, France
Lautram, Nolwenn; INSERM, U 646, Angers, France
Desreux, Jean-François ; Université de Liège - ULiège > Department of Chemistry > Laboratory of Coordination and Radiochemistry
Detrembleur, Christophe ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Polymer micelles decorated by gadolinium complexes as MRI blood contrast agents: design, synthesis and properties
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