Article (Scientific journals)
Regulation of B cell survival, development and function by inositol 1,4,5-trisphosphate 3-kinase B (Itpkb)
Schurmans, Stéphane; Pouillon, V.; Marechal, Y.
2011In Advances in Enzyme Regulation, 51, p. 66-73
Peer Reviewed verified by ORBi
 

Files


Full Text
SchurmansS_AdvancEnzymRegul_2010.pdf
Publisher postprint (531.13 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
cell survival; inositol 1,4,5-trisphosphate 3-kinase B; Itpkb
Abstract :
[en] In mammals, Ins(1,4,5)P3, the well known calcium mobilization messenger, is phosphorylated in the cytosol at the 3-position of the inositol ring to yield Ins(1,3,4,5)P4 by Ins(1,4,5)P3 3-kinases A, B and C isoforms as well as by inositol polyphosphate multikinase (Ipmk). Studies in gene-deficient mice have revealed that these enzymes and Ins(1,3,4,5)P4, their reaction product, play essential role in multiple physiological processes, ranging from synaptic plasticity, hematopoietic cell survival, development and function, to mRNA export, transcriptional regulation and chromatin remodelling. Rather than to provide an unique and “universal” mechanism of Ins(1,3,4,5)P4 action, these studies in genetically-modified mice point for a role of this inositide in the control of calcium mobilization, of the subcellular localisation of PH domain-containing target proteins, and of higher inositol phosphate production. Mice deficient for the B isoform of inositol 1,4,5-trisphosphate 3-kinase (Itpkb) develop profound alterations in T and B cells as well as in neutrophils and mast cells. Our recent studies indicate that the 3-kinase Itpkb and Ins(1,3,4,5)P4 are important for the survival of naïve mature B cells and the control of proapoptotic Bim protein expression, rather than for the control of B cell transition from one developmental stage to another. They also suggest that Itpkb is an important component in the control of B cell anergy.
Disciplines :
Genetics & genetic processes
Biochemistry, biophysics & molecular biology
Author, co-author :
Schurmans, Stéphane  ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Biochimie métabolique vétérinaire
Pouillon, V.;  Université Libre de Bruxelles - ULB > Institut de Recherches Interdisciplinaires en Biologie Humaine et Moléculaire (IRIBHM), Institut de Biologie et de Médecine
Marechal, Y.;  Université Libre de Bruxelles - ULB > Institut de Recherches Interdisciplinaires en Biologie Humaine et Moléculaire (IRIBHM), Institut de Biologie et de Médecine
Language :
English
Title :
Regulation of B cell survival, development and function by inositol 1,4,5-trisphosphate 3-kinase B (Itpkb)
Publication date :
2011
Journal title :
Advances in Enzyme Regulation
ISSN :
0065-2571
Publisher :
Pergamon Press, Oxford, United Kingdom
Volume :
51
Pages :
66-73
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 November 2010

Statistics


Number of views
42 (8 by ULiège)
Number of downloads
1 (1 by ULiège)

Scopus citations®
 
14
Scopus citations®
without self-citations
11
OpenCitations
 
14

Bibliography


Similar publications



Contact ORBi