Effect of Interferon-Gamma and Tumor Necrosis Factor-Alpha on Lymphoepithelial Interactions within Thymic Nurse Cells

[en] Isolated thymic nurse cells (TNC) represent a specialized microenvironment in vivo where thymocytes interact specifically with subcapsular epithelial cells. They are thought to play a critical role in the process of T cell differentiation. We demonstrate that recombinant murine interferon-gamma and recombinant human tumor necrosis factor-alpha can act on these interactions: they stimulate TNC-derived epithelial cells to establish interactions with thymocytes in vitro and to form new lymphoepithelial complexes. This phenomenon is partially inhibited by anti-Ia monoclonal antibodies. Implications of these findings for normal intrathymic differentiation are discussed.

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology

Author, co-author :

Defresne, Marie-Paule ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie

Humblet, Chantal ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie

Rongy, A. M.

Greimers, Roland ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Boniver, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Language :

English

Title :

Effect of Interferon-Gamma and Tumor Necrosis Factor-Alpha on Lymphoepithelial Interactions within Thymic Nurse Cells

Publication date :

February 1990

Journal title :

European Journal of Immunology

ISSN :

0014-2980

eISSN :

1521-4141

Publisher :

John Wiley & Sons, United Kingdom

Volume :

Issue :

Pages :

429-32

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 15 November 2010

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