Tetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression
Lakaye, Bernard ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique
Kim, Jinhyun
Heck, Rosario
Abassi, Yasmin
Diken, Mustapha
Sprengel, Rolf
Bockamp, Ernesto
Language :
English
Title :
Tetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression
Bockamp, E., Maringer, M., Spangenberg, C., Fees, S., Fraser, S., Eshkind, L., Oesch, F., Zabel, B., Of mice and models: Improved animal models for biomedical research (2002) Physiol Genomics, 11, pp. 115-32. , 12464688
Bockamp, E., Sprengel, R., Eshkind, L., Lehmann, T., Braun, J.M., Emmrich, F., Hengstler, J.G., Conditional transgenic mouse models: From the basics to genome-wide sets of knockouts and current studies of tissue regeneration (2008) Regen Med, 3, pp. 217-35. , 10.2217/17460751.3.2.217. 18307405
Sprengel, R., Hasan, M.T., Tetracycline-controlled genetic switches (2007) Handb Exp Pharmacol, pp. 49-72. , full-text. 17203651
Katsantoni, E.Z., Anghelescu, N.E., Rottier, R., Moerland, M., Antoniou, M., De Crom, R., Grosveld, F., Strouboulis, J., Ubiquitous expression of the rtTA2S-M2 inducible system in transgenic mice driven by the human hnRNPA2B1/CBX3 CpG island (2007) BMC Dev Biol, 7, p. 108. , 10.1186/1471-213X-7-108. 17900353
Bornkamm, G.W., Berens, C., Kuklik-Roos, C., Bechet, J.M., Laux, G., Bachl, J., Korndoerfer, M., Malamoussi, A., Stringent doxycycline-dependent control of gene activities using an episomal one-vector system (2005) Nucleic Acids Res, 33, p. 5137. , 10.1093/nar/gni137. 16147984
Roth, S., Franken, P., Van Veelen, W., Blonden, L., Raghoebir, L., Beverloo, B., Van Drunen, E., Fodde, R., Generation of a tightly regulated doxycycline-inducible model for studying mouse intestinal biology (2009) Genesis, 47, pp. 7-13. , 10.1002/dvg.20446. 18942097
Zhu, P., Aller, M.I., Baron, U., Cambridge, S., Bausen, M., Herb, J., Sawinski, J., Nelson, M.L., Silencing and un-silencing of tetracycline-controlled genes in neurons (2007) PLoS One, 2, p. 5533. , 10.1371/journal.pone.0000533. 17579707
Srinivas, S., Watanabe, T., Lin, C.S., William, C.M., Tanabe, Y., Jessell, T.M., Costantini, F., Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus (2001) BMC Dev Biol, 1, p. 4. , 10.1186/1471-213X-1-4. 11299042
Friedrich, G., Soriano, P., Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice (1991) Genes Dev, 5, pp. 1513-23. , 10.1101/gad.5.9.1513. 1653172
Soriano, P., Generalized lacZ expression with the ROSA26 Cre reporter strain (1999) Nat Genet, 21, pp. 70-1. , 10.1038/5007. 9916792
Schwenk, F., Baron, U., Rajewsky, K., A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells (1995) Nucleic Acids Res, 23, pp. 5080-1. , 10.1093/nar/23.24.5080. 8559668
Strathdee, D., Ibbotson, H., Grant, S., Expression of transgenes targeted to the Gt(ROSA)26Sor locus is orientation dependent (2006) PLoS One, 1, p. 54. , 10.1371/journal.pone.0000004. 17183668
Mao, X., Fujiwara, Y., Chapdelaine, A., Yang, H., Orkin, S.H., Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain (2001) Blood, 97, pp. 324-6. , 10.1182/blood.V97.1.324. 11133778
Luche, H., Weber, O., Nageswara Rao, T., Blum, C., Fehling, H.J., Faithful activation of an extra-bright red fluorescent protein in "knock-in" Cre-reporter mice ideally suited for lineage tracing studies (2007) Eur J Immunol, 37, pp. 43-53. , 10.1002/eji.200636745. 17171761
Stoller, J.Z., Degenhardt, K.R., Huang, L., Zhou, D.D., Lu, M.M., Epstein, J.A., Cre reporter mouse expressing a nuclear localized fusion of GFP and beta-galactosidase reveals new derivatives of Pax3-expressing precursors (2008) Genesis, 46, pp. 200-4. , 10.1002/dvg.20384. 18395835
Hameyer, D., Loonstra, A., Eshkind, L., Schmitt, S., Antunes, C., Groen, A., Bindels, E., Meuwissen, R., Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues (2007) Physiol Genomics, 31, pp. 32-41. , 10.1152/physiolgenomics.00019.2007. 17456738
Hochedlinger, K., Yamada, Y., Beard, C., Jaenisch, R., Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues (2005) Cell, 121, pp. 465-77. , 10.1016/j.cell.2005.02.018. 15882627
Jullien, N., Goddard, I., Selmi-Ruby, S., Fina, J.L., Cremer, H., Herman, J.P., Use of ERT2-iCre-ERT2 for conditional transgenesis (2008) Genesis, 46, pp. 193-9. , 10.1002/dvg.20383. 18395834
Mayford, M., Bach, M.E., Huang, Y.Y., Wang, L., Hawkins, R.D., Kandel, E.R., Control of memory formation through regulated expression of a CaMKII transgene (1996) Science, 274, pp. 1678-83. , 10.1126/science.274.5293.1678. 8939850
MacK, V., Burnashev, N., Kaiser, K.M., Rozov, A., Jensen, V., Hvalby, O., Seeburg, P.H., Sprengel, R., Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice (2001) Science, 292, pp. 2501-4. , 10.1126/science.1059365. 11431570
Gunther, E.J., Moody, S.E., Belka, G.K., Hahn, K.T., Innocent, N., Dugan, K.D., Cardiff, R.D., Chodosh, L.A., Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis (2003) Genes Dev, 17, pp. 488-501. , 10.1101/gad.1051603. 12600942
Contag, C.H., Bachmann, M.H., Advances in in vivo bioluminescence imaging of gene expression (2002) Annu Rev Biomed Eng, 4, pp. 235-60. , 10.1146/annurev.bioeng.4.111901.093336. 12117758
Zambrowicz, B.P., Imamoto, A., Fiering, S., Herzenberg, L.A., Kerr, W.G., Soriano, P., Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells (1997) Proc Natl Acad Sci USA, 94, pp. 3789-94. , 10.1073/pnas.94.8.3789. 9108056
Krestel, H.E., Mayford, M., Seeburg, P.H., Sprengel, R., A GFP-equipped bidirectional expression module well suited for monitoring tetracycline-regulated gene expression in mouse (2001) Nucleic Acids Res, 29, p. 539. , 10.1093/nar/29.7.e39. 11266574
Freundlieb, S., Schirra-Muller, C., Bujard, H., A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells (1999) J Gene Med, 1, pp. 4-12. , 10.1002/(SICI)1521-2254 (199901/02)1:1<4: :AID-JGM4 >3.0.CO
2-Y. 10738580
Rossi, F., Blau, H., Recent advances in inducible gene expression systems (1998) Curr Opin Biotechnol, 9, pp. 451-6. , 10.1016/S0958-1669(98)80028-1. 9821271
Backman, C.M., Zhang, Y., Malik, N., Shan, L., Hoffer, B.J., Westphal, H., Tomac, A.C., Generalized tetracycline induced Cre recombinase expression through the ROSA26 locus of recombinant mice (2009) J Neurosci Methods, 176, pp. 16-23. , 10.1016/j.jneumeth.2008.08.024. 18801387
Krestel, H.E., Shimshek, D.R., Jensen, V., Nevian, T., Kim, J., Geng, Y., Bast, T., Schwenk, F., A genetic switch for epilepsy in adult mice (2004) J Neurosci, 24, pp. 10568-78. , 10.1523/JNEUROSCI.4579-03.2004. 15548671
Hasegawa, K., Nakatsuji, N., Insulators prevent transcriptional interference between two promoters in a double gene construct for transgenesis (2002) FEBS Lett, 520, pp. 47-52. , 10.1016/S0014-5793(02)02761-8. 12044868
Kadesch, T., Berg, P., Effects of the position of the simian virus 40 enhancer on expression of multiple transcription units in a single plasmid (1986) Mol Cell Biol, 6, pp. 2593-601. , 3023940
Proudfoot, N.J., Transcriptional interference and termination between duplicated alpha-globin gene constructs suggests a novel mechanism for gene regulation (1986) Nature, 322, pp. 562-5. , 10.1038/322562a0. 3736674
Bond, C.T., Sprengel, R., Bissonnette, J.M., Kaufmann, W.A., Pribnow, D., Neelands, T., Storck, T., Maylie, J., Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3 (2000) Science, 289, pp. 1942-6. , 10.1126/science.289.5486.1942. 10988076
Urlinger, S., Baron, U., Thellmann, M., Hasan, M.T., Bujard, H., Hillen, W., Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity (2000) Proc Natl Acad Sci USA, 97, pp. 7963-8. , 10.1073/pnas.130192197. 10859354
Jerecic, J., Schulze, C.H., Jonas, P., Sprengel, R., Seeburg, P.H., Bischofberger, J., Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression (2001) Brain Res Mol Brain Res, 94, pp. 96-104. , 10.1016/S0169-328X(01)00221-2. 11597769
Storck, T., Krüth, U., Kolhekar, R., Sprengel, R., Seeburg, P., Rapid construction in yeast of complex targeting vectors for gene manipulation in the mouse (1996) Nucleic Acids Res, 24, pp. 4594-6. , 10.1093/nar/24.22.4594. 8948655
Logan, J., Shenk, T., Adenovirus tripartite leader sequence enhances translation of mRNAs late after infection (1984) Proc Natl Acad Sci USA, 81, pp. 3655-9. , 10.1073/pnas.81.12.3655. 6587381
Zolotukhin, S., Potter, M., Hauswirth, W.W., Guy, J., Muzyczka, N., A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells (1996) J Virol, 70, pp. 4646-54. , 8676491
Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W., Roder, J., Derivation of completely cell culture-derived mice from early-passage embryonic stem cells (1993) Proc Natl Acad Sci USA, 90, pp. 8424-8. , 10.1073/pnas.90.18.8424. 8378314
Spergel, D.J., Kruth, U., Hanley, D.F., Sprengel, R., Seeburg, P.H., GABA- and glutamate-activated channels in green fluorescent protein-tagged gonadotropin-releasing hormone neurons in transgenic mice (1999) J Neurosci, 19, pp. 2037-50. , 10066257
Bockamp, E., Antunes, C., Maringer, M., Heck, R., Presser, K., Beilke, S., Ohngemach, S., Sprengel, R., Tetracycline-controlled transgenic targeting from the SCL locus directs conditional expression to erythrocytes, megakaryocytes, granulocytes, and c-kit-expressing lineage-negative hematopoietic cells (2006) Blood, 108, pp. 1533-41. , 10.1182/blood-2005-12-012104. 16675709