Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli.

Apoptosis/drug effects; Cell Cycle Proteins/antagonists & inhibitors; Cytostatic Agents/chemical synthesis/pharmacology; Inhibitory Concentration 50; Neoplasms/drug therapy/pathology; Nuclear Proteins/antagonists & inhibitors; Protein-Serine-Threonine Kinases/antagonists & inhibitors; Protein-Tyrosine Kinases/antagonists & inhibitors; Structure-Activity Relationship; Vanillic Acid/chemical synthesis/pharmacology/therapeutic use

Abstract :

[en] A series of 33 novel divanillates and trivanillates were synthesized and found to possess promising cytostatic rather than cytotoxic properties. Several compounds under study decreased by >50% the activity of Aurora A, B, and C, and WEE1 kinase activity at concentrations <10% of their IC(50) growth inhibitory ones, accounting, at least partly, for their cytostatic effects in cancer cells and to a lesser extent in normal cells. Compounds 6b and 13c represent interesting starting points for the development of cytostatic agents to combat cancers, which are naturally resistant to pro-apoptotic stimuli, including metastatic malignancies.

Research Center/Unit :

CIP - Centre d'Ingénierie des Protéines - ULiège

Disciplines :

Oncology

Author, co-author :

Lamoral-Theys, Delphine

Pottier, Laurent

Kerff, Frédéric ; Université de Liège - ULiège > Centre d'ingénierie des protéines

Dufrasne, Francois

Proutiere, Fabien

Wauthoz, Nathalie

Neven, Philippe

Ingrassia, Laurent

Antwerpen, Pierre Van

Lefranc, Florence

More authors (7 more)

Language :

English

Title :

Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli.

Publication date :

2010

Journal title :

Bioorganic and Medicinal Chemistry

ISSN :

0968-0896

eISSN :

1464-3391

Publisher :

Elsevier Science, Oxford, United Kingdom

Volume :

Issue :

Pages :

3823-33

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 03 November 2010

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