[en] A series of 33 novel divanillates and trivanillates were synthesized and found to possess promising cytostatic rather than cytotoxic properties. Several compounds under study decreased by >50% the activity of Aurora A, B, and C, and WEE1 kinase activity at concentrations <10% of their IC(50) growth inhibitory ones, accounting, at least partly, for their cytostatic effects in cancer cells and to a lesser extent in normal cells. Compounds 6b and 13c represent interesting starting points for the development of cytostatic agents to combat cancers, which are naturally resistant to pro-apoptotic stimuli, including metastatic malignancies.
Research center :
CIP - Centre d'Ingénierie des Protéines - ULiège
Disciplines :
Oncology
Author, co-author :
Lamoral-Theys, Delphine
Pottier, Laurent
Kerff, Frédéric ; Université de Liège - ULiège > Centre d'ingénierie des protéines
Dufrasne, Francois
Proutiere, Fabien
Wauthoz, Nathalie
Neven, Philippe
Ingrassia, Laurent
Antwerpen, Pierre Van
Lefranc, Florence
Gelbcke, Michel
Pirotte, Bernard ; Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
Kraus, Jean*-Louis
Neve, Jean
Kornienko, Alexander
Kiss, Robert
Dubois, Jacques ; Université de Liège - ULiège > Services généraux (Faculté de philosophie et lettres) > Relations académiques et scientifiques (Philo et lettres)
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