Reversal of Neurological Deficit with Naloxone: An Additional Report

[en] We report the repeated improvement in neurological function following naloxone administration in a patient who developed acute hemiplegia after an intracranial neurological procedure. The mechanisms responsible for the neurological deficit and for its reversal by naloxone are discussed. A review of the literature suggests that the beneficial effect of naloxone can result from an improvement in haemodynamic status or from metabolic effects that could be favorable during cerebral ischaemia.

Disciplines :

Anesthesia & intensive care

Author, co-author :

Hans, Pol ; Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation

Brichant, Jean-François ; Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation

Longerstay, E.

Damas, François ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)

Remacle, J. M.

Language :

English

Title :

Reversal of Neurological Deficit with Naloxone: An Additional Report

Publication date :

1992

Journal title :

Intensive Care Medicine

ISSN :

0342-4642

eISSN :

1432-1238

Publisher :

Springer, Heidelberg, Germany

Volume :

Issue :

Pages :

362-3

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 27 October 2008

Statistics

Number of views

125 (5 by ULiège)

Number of downloads

210 (1 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Holaday J.W., Malcoln D.S. (1988) Endogenous opioids and other peptides: evidence for their clinical relevance in shock and CNS injury. The pharmacologic approach to the critically ill patient , B., Chernow, 2nd edn., Williams and Wilkins, Baltimore; 718-732.
Baskin D.S., Hosobuchi Y. (1981) Naloxone reversal of ischaemic neurologic deficits in man. Lancet 2:272-275.
Benzel E.C., Hadden T.A., Nossaman B.D., Lancon J., Kesterson L. (1990) Does sufentanil exacerbate marginal neurological dysfunction?. J Neurosurg Anesth 2:50-52.
Ada H.P., Olinger, Barson W.G. (1986) A dose escalation study of large doses of naloxone for treatment of patients with acute cerebral ischemia. Stroke 17:404-409.
Krechel S.W., Orr R.M., Comper N.B., Gufta N., Eggers G.W.N. (1989) Naloxone: report of a beneficial side effect. J Neurosurg Anesth 1:346-351.
Hariri R.J., Supra E.L., Roberts J.P., Lavigne M.H. (1986) Effect of naloxone on cerebral perfusion and cardiac performance during experimental cerebral ischemia. J Neurosurg 64:780-786.
Skarphedinsson J.O., Delle M., Hoffman P., Thoren P. (1989) The effects of naloxone on cerebral blood flow and cerebral function during relative cerebral ischemia. J Cereb Blood Flow Metab 9:515-522.
Wallace M.C., Tator C.H. (1986) Failure of naloxone to improve spinal cord blood flow and cardiac output after spinal cord injury. Neurosurgery 18:428-432.
Estanol B., Aguilar F., Corona T. (1985) Diagnosis of reversible versus irreversible cerebral ischemia by the intravenous administration of naloxone. Stroke 16:1006-1009.
Azar I., Turndorf H. (1979) Severe hypertension and multiple atrial premature contractions following naloxone administration. Anesth Analg 58:524-525.