Article (Scientific journals)
Technical validation of a face mask adapted for dry powder inhalation in the equine species
Duvivier, Dominique Hannia; Votion, Dominique; Vandenput, Sandrina et al.
1997In Equine Veterinary Journal, 29 (6), p. 471-476
Peer Reviewed verified by ORBi
 

Files


Full Text
DuvivierDH_VetJ_1997.pdf
Publisher postprint (3.96 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
horse; COPD; face mask; dry powder inhalation; bronchodilation
Abstract :
[en] Development of dry powder inhalation (DPI) for horses requires the use of an adapted face mask. In experiment I, 4 masks (A, B, C and D) were tested and factors influencing the delivery of the dry powder were determined. Mask A was one which is commercially available for metered-dose inhalation. Mask B had the same shape as Mask A but an airtight rubber seal was added for the connection between the mask and horse's head. Mask C was a prototype adapted for DPI with connection for the DPI device between the nostrils, airtight expiratory valves in front of each nostril and airtight rubber seal to attach the mask on the horse's head. Mask D was the same as Mask C but the airtight expiratory valve was situated in front of one nostril and the connection for the DPI device was placed in front of the other nostril. Inhalet emptying and peak inspiratory pressure were measured on 5 healthy horses with each face mask. Both Masks A and B gave a low rate of inhalet emptying. Inspiratory pressures created in Masks C and D were negative enough to ensure inhalet emptying rates of mean +/- s.d. 98.28 +/- 1.79% and 100% respectively. In experiment 2, the face masks giving the greatest inhalet emptying were used to test the therapeutic efficacy of ipratropium bromide DPI. This was tested on 6 horses suffering from acute exacerbation of chronic obstructive pulmonary disease (COPD). At a dose of 200 micrograms/100 kg bwt, ipratropium administered with Mask D improved significantly pulmonary function measurements compared to baseline values and placebo inhalation. With Mask C, a double dose of ipratropium (400 micrograms/100 kg bwt) was necessary to improve these parameters compared to baseline values. This indicated the importance of locating the DPI device in front of one nostril. It was concluded that inhalet emptying is correlated to inspiratory pressures measured in the face masks. Secondly, these pressures are in turn dependent on the air-tightness of the mask, i.e. air-tightness of the expiratory valve and close connection between the horse's head and the mask. Thirdly, position of the DPI device in front of a nostril allows bronchodilation at a dose half that required when the device is placed between the nostrils. Finally DPI using Mask D (EquiPoudre) is a rapid, effective and well tolerated inhalation treatment for COPD horses.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Duvivier, Dominique Hannia
Votion, Dominique  ;  Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Vandenput, Sandrina  ;  Université de Liège - ULiège > CARE "Le Réseau des bibliothèques" > Bibliothèque des Sciences de la vie
Art, Tatiana ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Phys. neuro-muscul., de l'effort - Méd. sport. des animaux
Lekeux, Pierre ;  Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie
Language :
English
Title :
Technical validation of a face mask adapted for dry powder inhalation in the equine species
Publication date :
1997
Journal title :
Equine Veterinary Journal
ISSN :
0425-1644
eISSN :
2042-3306
Publisher :
Equine Veterinary Journal Ltd, Newmarket, United Kingdom
Volume :
29
Issue :
6
Pages :
471-476
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 February 2009

Statistics


Number of views
124 (4 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
9
Scopus citations®
without self-citations
3
OpenCitations
 
6

Bibliography


Similar publications



Contact ORBi