[en] Six Warmblood horses suffering an acute exacerbation of COPD were tested to investigate whether inhalation of ipratropium bromide (IB) dry powder (2,400 microg) 30 min preexercise would improve their exercise capacity. A cross-over protocol with an inert powder placebo (P) was used. Mechanics of breathing and arterial blood gases were determined before treatment, after treatment but pre-exercise, and during an incremental exercise test. Oxygen consumption (VO2) was also measured before and during exercise, and the time to fatigue recorded. Inhalation of IB reduced total pulmonary resistance (RL) and maximum intrapleural pressure changes (deltaPpl(max)) and increased dynamic compliance before exercise. The onset of exercise was associated with a marked decrease in RL in P-treated horses but not those receiving IB, so that RL during exercise was not affected by treatment. Although deltaPpl(max) was lower at 8,9 and 10 m/s with IB, there were no treatment-related changes in VO2, blood gases, time to fatigue or any other measurement of breathing mechanics. Therefore, although inhalation of IB prior to exercise may have improved deltaPpl(max), it had no apparent impact on the horses' capacity for exercise.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Bayly, W. M.; Washington State University Pullman, USA > Department of Veterinary Clinical Sciences
Duvivier, D. H.; Université de Liège - ULiège > Faculté de Médecine Vétérinaire > Physiologie
Votion, Dominique ; Université de Liège - ULiège > Faculté de Médecine Vétérinaire > Physiologie
Vandenput, Sandrina ; Université de Liège - ULiège > Faculté de Médecine Vétérinaire > Physiologie
Art, Tatiana ; Université de Liège - ULiège > Faculté de Médecine Vétérinaire > Physiologie
Lekeux, Pierre ; Université de Liège - ULiège > Faculté de Médecine Vétérinaire > Physiologie
Language :
English
Title :
Effects of inhaled ipratropium bromide on breathing mechanics and gas exchange in exercising horses with chronic obstructive pulmonary disease
Publication date :
2002
Journal title :
Equine Veterinary Journal
ISSN :
0425-1644
eISSN :
2042-3306
Publisher :
Equine Veterinary Journal Ltd, Newmarket Suffolk, United Kingdom
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Ainsworth, D M (1998) Respiratory system In Equine Internal Medicine, Eds. S.M. Reed and W.M. Bayly, W.B Saunders Co., Philadelphia. pp 278-280
Ammann, V.J., Vrins, A A and Lavoie, J -P. (1998) Effects of inhaled beclomethasone dipropionate on respiratory function in horses with chronic obstructive pulmonary disease (COPD) Equine vet J. 30, 152-157.
Art, T., Desmecht, D., Amory, H and Lekeux, P. (1990a) Synchronisation of locomotion and respiration in trotting ponies J. vet. med. Ass. 37, 95-103
Art, T., Anderson, L , Woakes, A.J., Roberts, C., Butler, P.J., Snow, D.H. and Lekeux, P. (1990b) Mechanics of breathing during strenuous exercise in thoroughbred horses Respir. Physiol. 82, 279-283.
Art, T., Lekeux, P., Gustin, P , Desmecht, D., Amory, H. and Paiva, M (1989) Inertance of the respiratory system in ponies J. appl. Physiol. 67, 534-540
Art, T., Duvivier, D.H , Votion, D., Ancillaux, N., Vandenput, S., Bayly, W.M. and Lekeux, P. (1998) Does an acute COPD crisis modify the cardiorespiratory and ventilatory adjustments to exercise in horse? J. appl Physiol. 84, 845-852.
Bayly, W M. and Slocombe, R F (1997) Airflow mechanics in models of equine obstructive upper airway disease under conditions simulating exercise. Res. vet. Sci 62, 205-211.
Bayly, W.M., Schulz, D.A., Hodgson, D.R. and Gollnick, P.D (1987) Ventilatory response to exercise in horses with exercise-induced hypoxemia. In. Equine Exercise Physiology 2, Eds: J.R. Gillespie and N.E. Robinson, ICEEP Publications, Davis. California. pp 172-182.
Bayly, W.M , Slocombe, R.F., Schott II, H.C. and Hodgson, D.R. (1999) Intravenous furosemide affects mass specific V̇o2max, but not airway mechanics in exercising horses. Am J. vet Res 60, 1415-1422.
Bayly, W.M , Hodgson, D.R , Schulz, D.A., Dempsey, J A. and Gollnick, P.D. (1989) Exercise-induced hypercapnia in the horse. J. appl. Physiol. 67, 1958-1966.
Bayly, W.M., Hines, M.T., Sides, R.H., Hakala, J.E. and Matson, C (1996) Efficacy of aerosolized albuterol sulfate in the treatment of equine chronic obstructive pulmonary disease. Proc Symp. Comp. Respir. Soc. 14, 44.
Bayly, W.M., Slocombe, R.F., Schott II, H.C., Hines, M.T , Sides, R.H. and Hakala, J.E. (2001) Effects of inhalation of albuterol sulphate, ipratropium bromide, and frusemide on breathing mechanics and gas exchange in healthy exercising horses. Equine vet. J. 33, 302-310.
Belman, M.J., Brooks, L.R , Ross, D.J. and Mohsenifar, Z. (1991) Variability of breathlessness measurement in patients with chronic obstructive pulmonary disease Chest 99, 566-571.
Broadstone, R.V., Robinson, N.E. and Berney, C. (1988) Effects of atropine in ponies with recurrent airway obstruction J. appl. Physiol. 65, 2720-2725.
Cockcroft, A.E. and Berry, G. (1981) Randomised controlled trial in chronic respiratory disability. Thorax 36, 200-203.
Derksen, F.J. (1993) Chronic obstructive pulmonary disease In: Equine Respiratory Disorders, Ed: J. Beech, Lea & Febiger, Philadelphia pp 231-233.
Derksen, F.J , Robinson, N.E and Berney, C. (1992) Aerosol pirbuterol: bronchodilator activity and side effects in ponies with recurrent airway obstruction. Equine vet. J. 24, 107-112.
Derksen, F.J., Olszewski, M., Robinson, N.E., Berney, C., Hakala, J.E., Matson, C.J., and Ruth, D.T (1999) Aerosolized albuterol sulfate used as a bronchodilator in horses with recurrent airway obstruction Am J. vet. Res. 60, 689-693
Derksen, F.J., Olszewski, M., Robinson, N.E., Berney, C., Lloyd, J.W., Hakala, J., Maison, C. and Ruth, D. (1996) Use of a hand-held, metered-dose aerosol delivery device to administer pirbuterol acetate to horses with 'heaves'. Equine vet. J. 28, 306-310
Dosman, J., Bode, F., Urbanem, J., Antic, R., Martin, R and Macklem, P.F. (1975) Role of inertia in the measurement of dynamic compliance. J. appl. Physiol. 38, 64-69.
Duvivier, D.H., Chiap, P., Crommen, J and Lekeux, P (1997a) Evaluation of some parameters influencing the drug delivery from a dry powder inhalation device using an in vitro model of the horse airways Vet Res. 28, 557-564.
Duvivier, D.H., Votion, D , Vandenput, S., Art, T. and Lekeux, P. (1997b) Airway response of horses with COPD to dry powder inhalation of ipratropium bromide. Vet J. 154, 149-153
Duvivier, D.H., Votion, D., Vandenput, S., Art, T. and Lekeux, P. (1997c) Technical validation of a facemask adapted for dry powder inhalation in the equine species. Equine vet. J. 29, 471-476.
Erichsen, D.F., Aviad, A.D , Schultz, R H and Kennedy, T.J (1994) Clinical efficacy and safety of clenbuterol HCI when administered to effect in horses with chronic obstructive pulmonary disease (COPD). Equine vet. J 26, 331-336.
Evans, D.L. and Rose, R.J. (1988a) Determination and repeatability of maximal oxygen consumption and other cardiorespiratory measurements in the exercising horse. Equine vet. J 20, 94-98
Evans, D.L. and Rose, R.J (1988b) Cardiovascular and respiratory responses in Thoroughbred horses during treadmill exercise. J expt Biol. 134, 397-408.
Genetzky, R.M and Loparco, F.V. (1985) Clinical efficacy of clenbuterol with COPD in horses J equine vet. Sci. 5, 320-323.
Geor, R. and Johnston, G. (1993) Deposition of radiolabelled aerosols within the equine respiratory tract. Proc. Symp comp resp. Soc 12 (Abstr).
Goetz, T.E. (1984) Successful management of equine chronic obstructive pulmonary disease. Vet Med. 79, 1073-1078.
Goodman, S N. and Berlin, J.A. (1994) The use of predicted confidence intervals when planning experiments and the misuse of power when interpreting results Ann intern Med. 121, 200-206.
Hansson, E., Nyberg, J.A. and Olsson, B. (1985) Effects of intramuscular injection of terbutaline in the horse Svensk. Vet 37, 477-480.
Hoffman, A.M., Viel, L., Tesarowski, D.B. and Baird, J.D. (1993) Management of severe obstructive pulmonary disease with inhaled bronchodilator treatment in a horse. Can. vet. J. 34, 493-495.
Hopkins, S.R , Bayly, W M., Slocombe, R F., Wagner, H. and Wagner, P.D. (1998) Effect of prolonged heavy exercise on pulmonary gas exchange in horses J appl. Physiol 84, 1723-1730.
Johnson, B.D., Saupe, K.W and Dempsey, J.A. (1992) Mechanical constraints on exercise hypercapnea in endurance athletes. J appl. Physiol. 73, 874-886.
Killian, K.J., Leblanc, P. Martin, D H., Summers, E., Jones, N.L. and Campbell, E.J.M. (1992) Exercise capacity and ventilatory, circulatory, and symptom limitation in patients with chronic airflow limitation. Am. Rev. resp Dis 146, 935-940
Kiviloog, J. (1975) The effect of pretreatment with atropine in exercise-induced bronchoconstriction. Pediatrics 56, 940-941
Kvart, C., Carlsten, L., Dahl, L. and Ryden, L. (1987) Changes in arterial oxygen tension in COPD horses after reduction of exposure to dust in the feed and environment In. Equine Exercise Physiology 2, Eds: J.R. Gillespie and N.E. Robinson, ICEEP Publications. Davis, California. pp 753-758.
Lekeux, P. and Art, T (1994) The respiratory system: Anatomy, physiology, and adaptations to exercise In: The Athletic Horse, Eds: D.R. Hodgson and R.J. Rose, W.B. Saunders Co., Philadelphia pp 79-127.
McFadden Jr , E.R. (1984) Exercise performance in the asthmatic Am. Rev. respir Dis 129, S84-S87
McKiernan, B.C., Koritz, G.D., Scott, J.S., Berney, C and Robinson, N.E. (1990) Plasma theophylline concentration and lung function in ponies with recurrent airway obstruction. Equine vet. J. 22, 194-197.
Morgan, A.D., Peck, D.F and Buchanan, D R. (1983) Effects of attitudes and beliefs on exercise tolerance in chronic bronchitis Br med. J. 286, 171-173.
Murphy, J.R., McPherson, E.A. and Dixon, P.M. (1980) Chronic obstructive pulmonary disease (COPD): Effects of bronchodilator drugs on normal and affected horses. Equine vet. J 12, 10-14.
Pearson, E.G. and Riebold, T.W. (1989) Comparison of bronchodilators in alleviating clinical signs in horses with chronic obstructive pulmonary disease. J Am. vet med. Ass. 194, 1287-1291.
Persson, S G B. and Lindberg, R. (1991) Lung biopsy pathology and exercise tolerance in horses with chronic bronchiolitis. In: Equine Exercise Physiology 3, Eds: S.G.B Persson, A. Lindholm and L B. Jeffcott, ICEEP Publications, Davis, California pp 457-464
Robinson, N.E., Derksen, F.J., Berney, C. and Goossens, L. (1993) The airway response of horses with recurrent airway obstruction (heaves) to aerosol administration of ipratropium bromide. Equine vet. J. 25, 299-303.
Rush, B.R., Flaminio, M.J , Matson, C.J. and Hakala, J E. (1997) Inhaled beclomethasone dipropionate for treatment of heaves'. Proc vet. resp. Symp. 15, S19.
Sasse, H.H.L. (1988) Kontrollierte Versuche zum quantitativen Wirkungsnachweis von Ventipulmin-Losung bei COPD-Pferden. Tierarztl. Umschau. 43, 550-556
Sasse, H.L. and Hajer, R. (1978) NAB365, a beta 2-receptor sympathomimetic agent: clinical experience in horses with lung disease J. vet. Pharmacol. Therap. 1, 241-244.
Seaman, J., Erickson, B K., Kubo, K , Hiraga, A , Kai, M., Yamaya, Y. and Wagner, P.D. (1995) Exercise induced ventilation/perfusion inequality in the horse. Equine vet. J 27, 104-109
Slocombe, R.F., Covelli, G. and Bayly, W.M. (1992) Respiratory mechanics of horses during stepwise treadmill exercise tests: The effect of clenbuterol pretreatment Aust. vet. J 69, 221-225.
Suruda, T., Nakamura, H., Kobayashi, H , Uetani, K , Nishio, M., Higashimoto, Y , Funasako, M. and Ohata, M. (1993) Effects of aerosol oxitropium bromide and fenoterol on maximal exercise capacity in chronic obstructive pulmonary disease and their correlation with air flow during exercise and with parameters of maximal exercise Jap. J. Thoracic Dis. 31, 1089-1095
Tashkin, D.P., Katz, R.M , Kerschnar, H. Rachelefsky, G.S. and Siegel, S.C. (1977) Comparison of aerosolized atropine, isoproterenol, atropine plus isoproterenol, disodium cromoglycate and placebo in the prevention of exercise-induced asthma. Ann. Allergy 39, 311-318
Tesarowski, D.B , Viel, L , McDonell, W.N and Newhouse, M.T. (1994) The rapid and effective administration of a β2-agonist to horses with heaves using a compact inhalation device and metered-dose inhalers. Can vet J 35, 170-173
Toshima, M.T , Kaplan, R M and Ries, A.L. (1990) Experimental evaluation of rehabilitation in chronic obstructive pulmonary disease short term effects on exercise endurance and health status. Health Psychol. 9, 237-252.
Viel, L. and Tesarowski, D.B. (1994) Radioaerosol deposition in equids. Proc. Am. Ass equine Practnrs 40, 93-94.
Wagner, P.D., Gillespie, J.R., Landgren, G.L., Fedde, M.R., Jones, B.W., DeBowes, R M., Pieschl, R.L. and Erickson, H H. (1989) Mechanism of exercise-induced hypoxemia in horses. J appl. Physiol. 66, 1227-1233.
Willoughby, R.A. and McDonell, W.N (1979) Pulmonary function testing in horses. Vet. Clin N. Am.: Large Anim. Pract 1, 171-191.
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