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[en] We report a unique case of a gastric collision tumor composed of an intramural gastrin-secreting tumor and a papillotubular adenocarcinoma of the intestinal type discovered at autopsy in a patient with Zollinger-Ellison syndrome. There was extensive metastatic dissemination of the neuroendocrine component to regional lymph nodes and to the liver. The unusual macroscopical, histological, and immunohistochemical features of this case and its specific clinical setting are discussed.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
De Leval, Laurence ; Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
Hardy, Noelle; Centre Hospitalier Universitaire de Liège - CHU > Department of Pathology
Deprez, Manuel ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Delwaide, Jean ; Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Belaiche, Jacques ; Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Boniver, Jacques ; Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
Language :
English
Title :
Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome.
Brown N, Smith M (1973) Neoplastic diathesis of patients with carcinoid. Cancer 32:216-222
Cadiot G, Lebtahi R, Sarda L, Bonnaud G, Marmuse J, Vissuzaine C, Ruszniewski P, Le Guludec D, Mignon M (1996) Preoperative detection of duodenal gastrinomas and peripancreatic lymph nodes by somatostatin receptor scintigraphy. Gastroenterology 111:845-854
Corsi A, Bosman C (1995) Adenocarcinoma and atypical carcinoid: Morphological study of a gastric collision-type tumour in the carcinoma-carcinoid spectrum. Ital J Gastroenterol 27:303-308
Declich P, Tavani E, Bellone S, Porcellati M, Raimondi D, Grassini R, Carneiro F, Bordi C (2002) Sporadic, syndromic and Zollinger-Ellison syndrome associated fundic gland polyps consistently express cytokeratin 7. Virchows Arch 441:96-97
Gerstle J, Kauffman G, Koltun W (1995) The incidence, management, and outcome of patients with gastrointestinal carcinoids and second primary malignancies. J Am Coll Surg 180:427-432
Godwin II J (1975) Carcinoid tumors: An analysis of 2837 patients. Cancer 36:560-569
Klöppel G, Clemens A (1996) The biological relevance of gastric neuroendocrine tumors. Yale J Biol Med 69:69-74
Lewin K, Riddel R (1992) Endocrine cells. In: Lewin KJ (ed) Gastrointestinal Pathology and its Clinical Implications. Igaku-Shoin, New-York, pp 197-257
Liu T, Zhong S, Chen Y, Lin Y, Chen J, Li D, Wang DT, Gu CF, Yie SF (1989) Gastric gastrinoma. Chinese Med J 102: 774-782
Parks T (1970) Malignant carcinoid and adenocarcinoma of the stomach. Br J Surg 57:377-379
Rosenberg J, Welch J (1985) Carcinoid tumors of the colon: A study of 72 patients. Am J Surg 149:775-779
Royston C, Garnham J, Stagg B, Polak J (1972) The Zollinger-Ellison syndrome due to an infiltrating tumour of the stomach. Gut 13:638-642
Thompson N, Vinik A, Eckhauser F, Strodel W (1985) Extra-pancreatic gastrinomas. Surgery 98:1113-1120
Wolfe M, Jensen R (1987) Zollinger-Ellison syndrome. Current concepts in diagnosis and management. N Engl J Med 317:1200-1208
Yamashina M, Flinner R (1985) Concurrent occurrence of adenocarcinoma and carcinoid tumor of the stomach: A composite tumor or collision tumors? Am J Clin Pathol 83:233-236
Zollinger R, Ellison E (1955) Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann Surg 142:708-729