Article (Scientific journals)
Emerging therapeutic agents for onychomycosis.
Pierard, Gérald; Arrese Estrada, Jorge; Quatresooz, Pascale et al.
2007In Expert Opinion on Emerging Drugs, 12 (3), p. 345-53
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Keywords :
Administration, Oral; Administration, Topical; Animals; Antifungal Agents/administration & dosage/chemistry/therapeutic use; Drug Design; Drugs, Investigational/administration & dosage/chemistry/therapeutic use; Foot Dermatoses/drug therapy; Hand Dermatoses/drug therapy; Humans; Onychomycosis/drug therapy
Abstract :
[en] Onychomycosis is a frequent disorder that represents the most prevalent fungal infection, particularly among older individuals. Diverse fungi of the dermatophyte, non-dermatophyte mold and yeast families have been reported to be responsible for onychomycosis. The output from the pharmaceutical industry of new antifungals to treat onychomycosis has been limited over the last decade. Present treatment options include both oral and topical drugs, with oral therapies giving better outcomes. However, neither of these treatment options provides high cure rates that are durable. At present, azoles and allylamines are keeping the pivotal roles. New derivatives with a favorable risk-benefit ratio and new formulations of older azoles seem to be promising. Thus, ongoing drug development activities have focused on novel delivery technologies to facilitate incorporation of existing antifungal drugs inside the nail plate and the discovery of new active antifungals.
Disciplines :
Dermatology
Author, co-author :
Pierard, Gérald ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Arrese Estrada, Jorge ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Quatresooz, Pascale  ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Pierard, Claudine ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Language :
English
Title :
Emerging therapeutic agents for onychomycosis.
Publication date :
2007
Journal title :
Expert Opinion on Emerging Drugs
ISSN :
1472-8214
eISSN :
1744-7623
Publisher :
Informa Healthcare, London, United Kingdom
Volume :
12
Issue :
3
Pages :
345-53
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 06 February 2009

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