Le controle de la transcription genique en tant que nouvelle cible therapeutique dans le traitement de l'asthme

Desmet, Christophe; Louis, Renaud; Lekeux, Pierre; Bureau, Fabrice

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Le controle de la transcription genique en tant que nouvelle cible therapeutique dans le traitement de l'asthme

Desmet, Christophe; Louis, Renaud; Lekeux, Pierre et al.

2005 • In Revue Médicale de Liège, 60 (10), p. 789-795

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https://hdl.handle.net/2268/57226

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Keywords :

Transcription factor; Asthma; Glucocorticoid receptor; Nuclear Factor-κB; Activator Protein-1

Abstract :

[en] The recent advances in the knowledge of the molecular mechanisms underlying asthma have lead to a significant improvement of the current treatments of the disease and opened new perspectives for the development of therapeutic alternatives to inhaled corticosteroids. The selective targeting of transcription factors controlling the expression of the genes implicated in the pathogenesis of asthma is one of these privileged strategies. This review aims at describing the most promising new therapeutic targets in the control of asthmatic inflammation at the gene transcription level.
[fr] Les progrès récents dans la connaissance des mécanismes moléculaires de l'asthme ont permis d'améliorer significativement les traitements actuels de la maladie et d'ouvrir de nouvelles perspectives dans le développement de stratégies thérapeutiques alternatives aux glucocorticoïdes inhalés. Le ciblage spécifique de l'activité des facteurs de transcription impliqués dans la pathogenèse de l'asthme constitue l'une des voies privilégiées de ces nouvelles stratégies. Cette revue vise à fournir une vue d'ensemble des nouvelles voies thérapeutiques de l'asthme les plus prometteuses basées sur le contrôle de l'expression génique au niveau transcriptionnel

Disciplines :

Biochemistry, biophysics & molecular biology
Veterinary medicine & animal health

Author, co-author :

Desmet, Christophe ; Université de Liège - ULiège > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire

Louis, Renaud ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie

Lekeux, Pierre ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie

Bureau, Fabrice ; Université de Liège - ULiège > Département de sciences fonctionnelles > Biochimie et biologie moléculaire

Language :

French

Title :

Le controle de la transcription genique en tant que nouvelle cible therapeutique dans le traitement de l'asthme

Alternative titles :

[en] Control of Gene Transcription as a New Therapeutic Target in Asthma

Publication date :

2005

Journal title :

Revue Médicale de Liège

ISSN :

0370-629X

eISSN :

2566-1566

Publisher :

Université de Liège. Revue Médicale de Liège, Liège, Belgium

Volume :

Issue :

Pages :

789-795

Peer reviewed :

Peer reviewed

Available on ORBi :

since 27 May 2010

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