Transient modifications of respiratory capacity in thymic cells during murine radioleukemogenesis

[en] The evolution of mitochondrial oxidative phosphorylation was studied during cancer induction in a model of thymic radiolymphomagenesis in C57BL/Ka mice. During the preneoplastic period, thymuses displayed an increase of the cytochrome c oxidase activity and oxygen consumption together with oxidative DNA damage assessed by the presence of the 8-hydroxydeoxyguanine DNA base modification. These transient changes in mitochondrial functional activity were not observed in thymuses of mice rescued from lymphoma development by a bone marrow graft, suggesting an important role of mitochondria for neoplastic transformation in this model. which might therefore be of interest to test the utilization of antioxidants for the prevention of radiation-induced malignancies. (C) 2002 Elsevier Science Inc.

Disciplines :

Biochemistry, biophysics & molecular biology
Endocrinology, metabolism & nutrition

Author, co-author :

Verlaet, Myriam ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Service administratif de la Faculté (Médecine)

Duyckaerts, Claire ; Université de Liège - ULiège > Centre de l'oxygène : Recherche et développement (C.O.R.D.)

Rahmouni, Souad ; Université de Liège - ULiège > Département des sciences cliniques > Immunopathologie - Transplantation

Denis, Ghislaine

Humblet, Chantal ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie

Greimers, Roland ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Sluse, Francis ; Université de Liège - ULiège > Département des sciences de la vie > Bioénergétique et physiologie cellulaire

Boniver, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Defresne, Marie-Paule ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie

Language :

English

Title :

Transient modifications of respiratory capacity in thymic cells during murine radioleukemogenesis

Publication date :

01 July 2002

Journal title :

Free Radical Biology and Medicine

ISSN :

0891-5849

eISSN :

1873-4596

Publisher :

Pergamon-Elsevier Science Ltd, Oxford, United Kingdom

Volume :

Issue :

Pages :

76-82

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 22 November 2010

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Bibliography

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