Scintigraphy; Inhalaton to perfusion ratio; Pulmonary disease; Scintigraphie; Rapport inhalation/perfusion; Maladies respiratoires
Abstract :
[en] Scintigraphical analysis of the ratio of inhalation (I) to perfusion (Q) was designed to determine whether chronic pulmonary disease in horses induced mismatches in I/Q and to assess whether medical treatment would restore an I/Q distribution pattern identical to that of control horses. In addition, the results of the I/Q analysis were correlated with the alveolar-arterial PO2 difference (AaDO2). The I/Q matching found in a group of control horses was compared with the I/Q analysis of a group of diseased horses before and after their clinical signs had been treated. The analysis indicated that there was mismatching between I and Q before they were treated. The treatment improved the diseased horses, pulmonary function but there was still heterogeneity in the I/Q distribution after they had been treated. The I/Q analysis parameters were well correlated with the ratio of ventilation (VA) and pulmonary blood flow (Q), evaluated by the determination of AaDO2
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology Veterinary medicine & animal health
Author, co-author :
Votion, Dominique ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Ghafir, Y.
Vandenput, Sandrina ; Université de Liège - ULiège > CARE "Le Réseau des bibliothèques" > Bibliothèque des Sciences de la vie
Duvivier, D. H.
Art, Tatiana ; Université de Liège - ULiège > Département de sciences fonctionnelles > Phys. neuro-muscul., de l'effort - Méd. sport. des animaux
Lekeux, Pierre ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie
Language :
English
Title :
Analysis of Scintigraphical Lung Images before and after Treatment of Horses Suffering from Chronic Pulmonary Disease
Publication date :
1999
Journal title :
Veterinary Record
ISSN :
0042-4900
eISSN :
2042-7670
Publisher :
British Veterinary Medicine, London, United Kingdom
Volume :
144
Issue :
9
Pages :
232-236
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
AGNEW, J. E., FRANCIS, R. A., PAVIA, D. & CLARKE, S. W. (1982) Quantitative comparison of 99mTc-aerosol and 81mKr ventilation images. Clinical Physics and Physiological Measurements 3, 21-30
AMIS, T. C., PASCOE, J. R. & HORNOF, W. (1984) Topographical distribution of pulmonary ventilation and perfusion in the horse. American Journal of Veterinary Research 45, 1597-1601
BECK, K. C. (1987) Regional trapping of microspheres in the lung correlates well with regional blood flow. Journal of Applied Physiology 63, 883-889
BISGARD, G. E., ORR, J. A. & WILL, J. A. (1975) Hypoxic pulmonary hypertension in the pony. American Journal of Veterinary Research 36, 49-52
BRAIN, J. D. & VALBERG, P. A. (1979) Deposition of aerosol in the respiratory tract. American Review of Respiratory Disease 120, 1325-1373
CERRETELLI, P. & DI PRAMPERO, P. E. (1991) Pulmonary gas exchange. In The Lung: Scientific Foundations. Eds R. G. Crystal, J. B. West. New York, Raven Press, pp 1565-1572
COMROE, J. H., FORSTER, R. E., DUBOIS, A. B., BRISCOE, W. A. & CARLSEN, E. (1962) The Lung. Chicago, Year Book Medical Publishers, pp 339-341
DUVIVIER, D. H., BAYLY, W. M., VOTION, D., VANDENPUT, S., ART, T. & LEKEUX, P. (1997) Effects of inhaled ipratropium bromide on mechanics of breathing in horses with COPD during recovery from exercise. In Proceedings of the 15th Comparative Respiratory Society Meeting, Liege, Belgium. p 3.2
GREENING, A. P., MINIATI, M. & FAZIO, F. (1980) Regional deposition of aerosols in health and in airways obstruction: a comparison with Krypton-81m ventilation scanning. Bulletin European de Physiopathologie Respiratoire 16, 287-298
HEDENSTIERNA, G., NYMAN, G., KVART, C. & FUNKQUIST, B. (1987) Ventilation-perfusion relationships in the standing horse: an inert gas elimination study. Equine Veterinary Journal 19, 514-519
KÖHN, H., MOSTBECK, A., BACHMAYR, S., EBER, O., GALVAN, G., HOLM, C., KÖNIG, B., LIND, P., MARKT, B., OGRIS, E. & RETTENBACHER, L. (1993) 99mTc-DTPA aerosol for same-day post-perfusion ventilation imaging: results of a multicentre study. European Journal of Nuclear Medicine 20, 4-9
MELSOM, M. N., KRAMER-JOHANSEN, J., FLATEBO, T., MÜLLER, C. & NICOLAYSEN, G. (1997) Distribution of pulmonary ventilation and perfusion measured simultaneously in awake goats. Acta Physiologica Scandinavica 159, 199-208
MORROW, P. E. (1986) Factors determining hygroscopic aerosol deposition in airways. Physiological Review 66, 330-376
MURPHY, J. L., McPHERSON, E. A. & DIXON, P. M. (1980) Chronic obstructive pulmonary disease (COPD): effects of bronchodilator drug on normal and affected horses. Equine Veterinary Journal 12, 10-14
NYMAN, G., LINDBERG, R., WECKNER, D., BJÖRK, M., KVART, C. & PERSSON, S. G. B. (1991) Pulmonary gas exchange correlated to clinical signs and lung pathology in horses with chronic bronchiolitis. Equine Veterinary Journal 23, 253-260
O'CALLAGHAN, M. W., HORNOF, W. J., FISHER, P. E. & PASCOE, J. R. (1987) Exercise-induced pulmonary haemorrhage in the horses: results of a detailed clinical, post mortem and imaging study. VII. Ventilation/perfusion scintigraphy in horses with EIPH. Equine Veterinary Journal 19, 423-427
O'RIORDAN, T. G. & SMALDONE, G. C. (1994) Aerosols as indices of regional ventilation. Journal of Aerosol Medicine 7, 111-117
PIIPER, J. (1961) Variations of ventilation and diffusing capacity to perfusion determining the alveolar-arterial O2 difference: theory. Journal of Applied Physiology 16, 507-510
SMART, R. C., LYONS, N. R., BURKE, J. J. & WOOD, C. F. (1985) A combined procedure for 99mTc aerosol ventilation and perfusion imaging. European Journal of Nuclear Medicine 11, 65-68
VAN DEN BROM, W. E., CLERCX, C., VAN TOOR, A. J. & DE VRIES, H. W. (1989) Quantitative analysis of radioaerosol I and perfusion scintigraphy in dogs. Lung 167, 201-212
VANDENPUT, S., VOTION, D., DUVIVIER, D. H., VAN ERCK, E., ANCIAUX, N., ART, T. & LEKEUX, P. (1998) Effect of a set stabled environmental control on pulmonary function and airway reactivity of COPD affected horses. Veterinary Journal 155, 189-195
VOTION, D., GHAFIR, Y., MUNSTERS, K., DUVIVIER, D. H., ART, T. & LEKEUX, P. (1997a) Aerosol deposition in equine lungs following ultrasonic nebulisation versus jet aerosol delivery system. Equine Veterinary Journal 29, 388-393
VOTION, D., GHAFIR, Y., VANDENPUT, S., ART, T. & LEKEUX, P. (1996a) Effects of romifidine on pulmonary function in horses with chronic obstructive pulmonary disease in clinical remission (part I). Pflügers Archiv European Journal of Physiology 431, R324
VOTION, D., VANDENPUT, S., DUVIVIER, D. H., ART, T. & LEKEUX, P. (1997b) Analysis of equine scintigraphical lung images. Veterinary Journal 153, 49-61
VOTION, D., VANDENPUT, S., DUVIVIER, D. H., KELEMEN, B. S., VAN ERCK, E. & LEKEUX, P. (1996b) Effects of romifidine on pulmonary function in horses with chronic obstructive pulmonary disease in acute crisis (part II). Pflügers Archiv European Journal of Physiology 432, R144
WEST, J. B. (1977) Ventilation-perfusion relationships. American Review of Respiratory Disease 116, 9190943
WEST, J. B. (1990) Tests of pulmonary function. In Respiratory Physiology - The Essentials, 4th edn. Ed J. B. West. Baltimore, Williams & Wilkins. pp 143-159
WEST, J. B. & WAGNER, P. D. (1991) Ventilation - perfusion relationships. In The Lung: Scientific Foundations. Eds R. G. Crystal, J. B. West. New York, Raven Press, pp 1290-1305
WHITWELL, K. E. & GREET, T. R. C. (1984) Collection and evaluation of tracheobronchial washes in the horse. Equine Veterinary Journal 16, 499-508