Synthesis of copolymer brushes endowed with adhesion to stainless steel surfaces and antibacterial properties by controlled nitroxide-mediated radical polymerization
[en] Novel copolymer brushes have been synthesized by a two-step "grafting from" method that consists of the electrografting of poly(2-phenyl-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-ethylacrylate) onto stainless steel, followed by the nitroxide-mediated radical polymerization of 2-(dimethylamino ethyl)acrylate and styrene or n-butyl acrylate, initiated from the electrografted polyacrylate chains. The grafted copolymers were quaternized in order to endow them with antibacterial properties. Peeling tests have confirmed the strong adhesion of the grafted copolymer onto the stainless steel substrate. Quartz crystal microbalance experiments have proven that fibrinogen adhesion is lower on the hydrophilic quaternized films compared to the nonionic counterpart. Such quaternized copolymers exhibit significant antibacterial activity against the Gram-positive bacteria S. aureus and the Gram-negative bacteria E. coli.
Research Center/Unit :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry Materials science & engineering
Author, co-author :
Ignatova, Miléna; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Voccia, Samuel; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Gilbert, Bernard ; Université de Liège - ULiège > Department of Chemistry > Laboratory of Analytical Chemistry and Electrochemistry
Markova, Nadya; Bulgarian Academy of Sciences, Sofia, Bulgaria > Institute of Microbiology
Mercuri, Paola ; Université de Liège - ULiège > Center for Protein Engineering
Galleni, Moreno ; Université de Liège - ULiège > Center for Protein Engineering
Sciannamea, Valérie; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Lenoir, Sandrine ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Cossement, Damien; University of Mons-Hainaut (UMH) > Service de Chimie Inorganique et Analytique (LASSIE)
Gouttebaron, Rachel; University of Mons-Hainaut (UMH) > Service de Chimie Inorganique et Analytique (LASSIE)
Jérôme, Robert ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Christine ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Synthesis of copolymer brushes endowed with adhesion to stainless steel surfaces and antibacterial properties by controlled nitroxide-mediated radical polymerization
Publication date :
23 November 2004
Journal title :
Langmuir
ISSN :
0743-7463
eISSN :
1520-5827
Publisher :
Amer Chemical Soc, Washington, United States - Washington
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique F.R.S.-FNRS - Fonds de la Recherche Scientifique FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture
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