Fast Production of Highly Reactive No-Carrier-Added [18F]Fluoride for the Labeling of Radiopharmaceuticals

[en] The 18F labeling of radiopharmaceuticals requires nearly anhydrous solutions of [18F]fluoride. Aqueous K2CO3 is generally used to elute [18F]fluoride from an anion-exchange resin. Replacing aqueous K2CO3 with strong organic bases, such as the phosphazene base P2Et enabled the recovery of highly reactive [18F]fluoride and avoided the azeotropic evaporation of water, which is very difficult on a microchip device.

Research Center/Unit :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Chemistry

Author, co-author :

Lemaire, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron

Aerts, Joël ; Université de Liège - ULiège > Centre de recherches du cyclotron

Voccia, Samuel

Libert, Lionel ; Université de Liège - ULiège > Centre de recherches du cyclotron

Mercier, Frédéric ; Université de Liège - ULiège > Centre de recherches du cyclotron

Goblet, David ; Université de Liège - ULiège > Centre de recherches du cyclotron

Plenevaux, Alain ; Université de Liège - ULiège > Centre de recherches du cyclotron

Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron

Language :

English

Title :

Fast Production of Highly Reactive No-Carrier-Added [18F]Fluoride for the Labeling of Radiopharmaceuticals

Publication date :

2010

Journal title :

Angewandte Chemie International Edition

ISSN :

1433-7851

eISSN :

1521-3773

Publisher :

Wiley-VCH Verlag Gmbh, Weinheim, Germany

Volume :

Pages :

1-5

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 27 April 2010

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