Comparative Evaluation of Four Detectors in the High-Performance Liquid Chromatographic Analysis of Chiral Nonaromatic Alcohols

Toussaint, B.; Duchateau, A. L.; van der Wal, S.; Albert, Adelin; Hubert, Philippe; Crommen, Jacques

doi:10.1093/chromsci/38.10.450

Article (Scientific journals)

Comparative Evaluation of Four Detectors in the High-Performance Liquid Chromatographic Analysis of Chiral Nonaromatic Alcohols

Toussaint, B.; Duchateau, A. L.; van der Wal, S. et al.

2000 • In Journal of Chromatographic Science, 38 (10), p. 450-7

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https://hdl.handle.net/2268/3816

DOI
10.1093/chromsci/38.10.450

PubMed
11048782

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Abstract :

[en] A comparative evaluation of ultraviolet, polarimetric, refractive index, and evaporative light-scattering detection coupled with high-performance liquid chromatography has been developed for the separation and quantitation of the enantiomers of chiral nonaromatic alcohols, some of which are intermediates in the synthesis of chiral drugs. (R,S)-3-tert-butylamino-1,2-propanediol; (R,S)-glycidol; and (R,S)-1-(4-morpholino)-2-octanol are selected as model compounds in order to compare the detection sensitivity and the linearity of the response with the four detectors. Separation of the enantiomers is performed using chiral stationary phases in normal-phase liquid chromatography. A one-day validation is achieved for (S)-3-tert-butylamino-1,2-propanediol with each detector, and limits of quantitation are determined for the three compounds. Advantages and limitations of the four detectors are discussed.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Toussaint, B.

Duchateau, A. L.

van der Wal, S.

Albert, Adelin ; Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique

Hubert, Philippe ; Université de Liège - ULiège > Chimie analytique

Crommen, Jacques ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Language :

English

Title :

Comparative Evaluation of Four Detectors in the High-Performance Liquid Chromatographic Analysis of Chiral Nonaromatic Alcohols

Publication date :

October 2000

Journal title :

Journal of Chromatographic Science

ISSN :

0021-9665

eISSN :

1945-239X

Publisher :

Preston Publications, United States - Illinois

Volume :

Issue :

Pages :

450-7

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 May 2010

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