Article (Scientific journals)
Selective Antiprotozoal Activity of Some Strychnos Alkaloids
Wright, Colin; Allen, David; Cai, Ya et al.
1994In Phytotherapy Research, 8, p. 149-152
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Keywords :
antiprotozoal; Entamoeba histolytica; Giardia intestinalis; Plasmodium falciparum; Strychnos usambarensis; Strychnos variabilis; KB cells; indole alkaloids; Strychnos henningsii
Abstract :
[en] The in vitro activities of 28 Strychnos alkaloids have been determined against three species of protozoa and the most active compounds were then assessed for in vitro cytotoxic activity against KB cells. 3',4'-dihydrousambarensine was the most active against Plasmodium falciparum and was relatively nontoxic to KB cells (cytotoxic/antiplasmodial ratio, 1474). Usambarensine displayed the most selectivity against Entamoeba histolytica while "',4'-dihydrousambarensine was the most selective compound against Giardia intestinalis although the cytotoxic/antiprotozoal ratios (20.4 and 6.6 respectively) were less favourable than the above.The four strychnobiline-type alkaloids were found devoid of activity against E. histolytica and G. intestinalis but to have weak antiplasmodial properties (7-13 times less active than chloroquine). None of the compounds containing only one indole ring system displayed antiprotozoal properties.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Wright, Colin
Allen, David
Cai, Ya
Chen, Zhenping
Phillipson, J.
Kirby, Geoffrey
Warhurst, David
Tits, Monique ;  Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
Selective Antiprotozoal Activity of Some Strychnos Alkaloids
Publication date :
1994
Journal title :
Phytotherapy Research
ISSN :
0951-418X
eISSN :
1099-1573
Publisher :
Wiley, Chichester, United Kingdom
Volume :
8
Pages :
149-152
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 May 2010

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