Article (Scientific journals)
Protein-protein interactions and gene expression regulation in HTLV-1 infected cells.
Legros, Sébastien; Boxus, Mathieu; Dewulf, Jean Francois et al.
2009In Frontiers in Bioscience: A Journal and Virtual Library, 14, p. 4138-48
Peer Reviewed verified by ORBi
 

Files


Full Text
Legros et al 2009.pdf
Publisher postprint (640.91 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Gene Expression Regulation, Viral; Human T-lymphotropic virus 1/genetics/metabolism; Humans; Protein Binding; Viral Proteins/metabolism
Abstract :
[en] Human T-cell leukemia virus type 1 (HTLV-1) propagates in CD4 or CD8 T cells and, after extended latency periods of 30-50 years, causes a rapidly fatal leukemia called adult T-cell leukemia/lymphoma (ATL). Infection with HTLV-1 is also associated with a degenerative neuromuscular disease referred to as tropical spastic paraparesis or HTLV-1-associated myelopathy. HTLV genome, in addition to the structural proteins and retroviral enzymes, codes for a region at its 3' end originally designated pX. The products of this region (Tax, Rex, p12I, p13II, p30II and HBZ) play important roles in deregulation of cellular functions by either directly disrupting cellular factors or altering transcription of viral and cellular genes. Here, we will review current knowledge of protein-protein interactions that regulate transcriptional functions of proteins encoded by the pX region.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Legros, Sébastien ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Boxus, Mathieu ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Dewulf, Jean Francois
Dequiedt, Franck  ;  Université de Liège - ULiège > GIGA-Research
Kettmann, Richard ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Twizere, Jean-Claude  ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech
Language :
English
Title :
Protein-protein interactions and gene expression regulation in HTLV-1 infected cells.
Publication date :
2009
Journal title :
Frontiers in Bioscience: A Journal and Virtual Library
ISSN :
1093-9946
eISSN :
1093-4715
Publisher :
Frontiers in Bioscience Publications, Tampa, United States - Florida
Volume :
14
Pages :
4138-48
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 January 2010

Statistics


Number of views
139 (18 by ULiège)
Number of downloads
301 (5 by ULiège)

Scopus citations®
 
7
Scopus citations®
without self-citations
6
OpenCitations
 
5

Bibliography


Similar publications



Contact ORBi