Molecular cloning and characterisation of the CD18 partner in ovine (Ovis aries) beta(2)-integrins

[en] The leukocyte integrins play a critical role in a number of cellular adhesive interactions during the immune response. We describe here the isolation and characterization of the ovine beta(2) (CD18) subunit, common to the leukocyte beta(2)-integrin family. The deduced 770-amino-acid sequence reveals a transmembrane protein with 81%, 83% and 95% identity with its murine, human and bovine homologues, respectively. Comparisons of CD18 sequences emphasize the functional importance of the beta(2) subunit I-like domain and included metal ion-dependent adhesion site (MIDAS)-like motif and confirm that of the cytoplasmic tail. The data provided here will offer the possibility to explore new avenues in studies based on the ovine model. (C) 2004 Elsevier B.V. All rights reserved.

Disciplines :

Genetics & genetic processes

Author, co-author :

Zecchinon, Laurent ; Université de Liège - ULiège > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies

Fett, Thomas ; Université de Liège - ULiège > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies

Baise, Etienne ; Université de Liège - ULiège > Département des sciences de la vie > Macromolécules biologiques

Desmecht, Daniel ; Université de Liège - ULiège > Département de Morphologie et Pathologie > Pathologie spéciale et autopsies

Language :

English

Title :

Molecular cloning and characterisation of the CD18 partner in ovine (Ovis aries) beta(2)-integrins

Publication date :

2004

Journal title :

Gene

ISSN :

0378-1119

eISSN :

1879-0038

Publisher :

Elsevier Science Bv, Amsterdam, Netherlands

Volume :

334

Pages :

47-52

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 08 January 2010

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