Molecular characterization of the caprine (Capra hircus) lymphocyte function-associated antigen-1 alpha subunit

[en] Background: Lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18, alpha L beta 2) is required for many cellular adhesive interactions during the immune response. Results: The Capra hircus CD11a-encoding cDNA was sequenced and compared with its human, murine, rat, bovine and ovine counterparts. Despite some focal differences, it shares all the main characteristics of its known mammalian homologues. Conclusion: Therefore, along with the caprine CD18-encoding cDNA, which has been available for a few months, the sequence data revealed here will allow the Capra hircus LFA-1 expression in vitro as a tool to explore the specificities of inflammation in the caprine species.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Fett, Thomas ; Université de Liège - ULiège > Département de morphologie et pathologie > Pathologie spéciale et autopsies

Zecchinon, Laurent ; Université de Liège - ULiège > Département de morphologie et pathologie > Pathologie spéciale et autopsies

Baise, Etienne ; Université de Liège - ULiège > Département des sciences de la vie > Macromolécules biologiques

Desmecht, Daniel ; Université de Liège - ULiège > Département de morphologie et pathologie > Pathologie spéciale et autopsies

Language :

English

Title :

Molecular characterization of the caprine (Capra hircus) lymphocyte function-associated antigen-1 alpha subunit

Publication date :

2005

Journal title :

BMC Veterinary Research

eISSN :

1746-6148

Publisher :

BioMed Central

Pages :

1:4

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

SPF Santé - Service Public Fédéral Santé publique. Sécurité de la Chaîne alimentaire et Environnement

Available on ORBi :

since 08 January 2010

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