Critical illness; Post-intensive care syndrome; Recovery; Trajectory; Very old; Humans; Intensive Care Units; Quality of Life; Aged, 80 and over; Recovery of Function; Survivors/psychology; Critical Illness/rehabilitation; Critical Illness/psychology; Critical Care/methods; Gerontology; Geriatrics and Gerontology
Abstract :
[en] [en] RESEARCH QUESTION: How can recovery trajectories after critical illness in very old ICU survivors be better understood and potentially modified across the continuum of care?
MAIN FINDINGS: Recovery trajectories in very old ICU survivors are highly heterogeneous and result from the interaction between baseline vulnerability (frailty, multimorbidity, social factors), the acute stress of critical illness, and individual resilience. Opportunities to influence these trajectories exist at multiple stages, including prehabilitation before ICU admission,brain- and neuromuscular-protective strategies during ICU stay, and structured, transdisciplinary post-ICU follow-up.
CONCLUSION: A shift from survival-focused metrics to a trajectory-based, transdisciplinary approach is essential to improve functional recovery and quality of life in very old ICU survivors.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Rousseau, Anne-Françoise ; Université de Liège - ULiège > Département des sciences cliniques > Soins intensifs ; Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs généraux
Balde, Detlef; Division of Anesthesiology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile
Beil, Michael; Department of Medicine, National Health Service Scotland, Inverness, UK
Bruyère, Olivier ; Université de Liège - ULiège > Unité de recherche Santé publique, épidémiologie et économie de la santé (URSAPES)
Berger-Estilita, Joana; Institute of Anaesthesiology and Intensive Care, Salemspital, Hirslanden Medical Group, Bern, Switzerland ; Institute for Medical Education, University of Bern, Bern, Switzerland ; CINTESIS@RISE, Centre for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal
Language :
English
Title :
Improving long-term trajectories in very old survivors of intensive care: a narrative review.
Publication date :
August 2026
Journal title :
European Geriatric Medicine
ISSN :
1878-7649
eISSN :
1878-7657
Publisher :
Springer Science and Business Media Deutschland GmbH, Switzerland
Amado FS Moura ECR Oliveira CMB Dibai-Filho AV Neto JN da Cunha LP Clinical characteristics and outcomes of critically ill elderly patients aged 90 years and older Sci Rep 2025 15 20486 1:CAS:528:DC%2BB2MXhs1GrtbzE 40595833 12216721 10.1038/s41598-025-05343-z
Hiser SL Fatima A Ali M Needham DM Post-intensive care syndrome (PICS): recent updates J Intensive Care 2023 11 23 37221567 10202754 10.1186/s40560-023-00670-7
Jung C Marschall U Hennig B Giemsa M Heramvand N Parco C Kelm M Jacobs JM Beil M Five-year mortality and functional trajectories in older survivors of intensive care compared to the general population Intensive Care Med 2025 51 2329 2340 41247496 12678597 10.1007/s00134-025-08163-x
Heyland DK Garland A Bagshaw SM Cook D Rockwood K Stelfox HT Dodek P Fowler RA Turgeon AF Burns K Muscedere J Kutsogiannis J Albert M Mehta S Jiang X Day AG Recovery after critical illness in patients aged 80 years or older: a multi-center prospective observational cohort study Intensive Care Med 2015 41 1911 1920 26306719 10.1007/s00134-015-4028-2
Wang S Allen D Kheir YN Campbell N Khan B Aging and post-intensive care syndrome: a critical need for geriatric psychiatry Am J Geriatr Psychiatry 2018 26 212 221 28716375 10.1016/j.jagp.2017.05.016
Rousseau AF Prescott HC Brett SJ Weiss B Azoulay E Creteur J Latronico N Hough CL Weber-Carstens S Vincent JL Preiser JC Long-term outcomes after critical illness: recent insights Crit Care 2021 25 108 33731201 7968190 10.1186/s13054-021-03535-3
De Silva S Urwin A Grimwood C Goh EKE Higgins AM Hodgson CL Health-related quality of life of adult sepsis survivors following critical illness: a systematic review Crit Care Explor 2025 7 40138536 11949298 e1238
Zegers M Porter L Simons K van den Boogaard M What every intensivist should know about quality of life after critical illness J Crit Care 2024 10.1016/j.jcrc.2024.154789 39608045
Tabah A Philippart F Timsit JF Willems V Francais A Leplege A Carlet J Bruel C Misset B Garrouste-Orgeas M Quality of life in patients aged 80 or over after ICU discharge Crit Care 2010 14 R2 20064197 2875504 10.1186/cc8231
Isaacowitz DM What do we know about aging and emotion regulation? Perspect Psychol Sci 2022 17 1541 1555 35605229 9633333 10.1177/17456916211059819
MacLeod S Musich S Hawkins K Alsgaard K Wicker ER The impact of resilience among older adults Geriatr Nurs 2016 37 266 272 27055911 10.1016/j.gerinurse.2016.02.014
Rai S Brace C Ross P Darvall J Haines K Mitchell I van Haren F Pilcher D Characteristics and outcomes of very elderly patients admitted to intensive care: a retrospective multicenter cohort analysis Crit Care Med 2023 51 1328 1338 37219961 10497207 10.1097/CCM.0000000000005943
Auriemma CL Harhay MO Haines KJ Barg FK Halpern SD Lyon SM What matters to patients and their families during and after critical illness: a qualitative study Am J Crit Care 2021 30 11 20 33385204 8101225 10.4037/ajcc2021398
Mittel A Hua M Supporting the geriatric critical care patient: decision making, understanding outcomes, and the role of palliative care Anesthesiol Clin 2019 37 537 546 31337483 6719536 10.1016/j.anclin.2019.04.011
Morgan A Long-term outcomes from critical care Surgery (Oxf) 2021 39 53 57 33519011 10.1016/j.mpsur.2020.11.005
Rousseau AF Fraipont V Preiser JC Post-intensive care syndrome is a potential consequence of critical care: can intensivists afford to look away? Intensive Care Med 2025 51 2135 2140 41081798 10.1007/s00134-025-08156-w
Brummel NE Balas MC Morandi A Ferrante LE Gill TM Ely EW Understanding and reducing disability in older adults following critical illness Crit Care Med 2015 43 1265 1275 25756418 4640688 10.1097/CCM.0000000000000924
Cosarderelioglu C Walston JD Abadir PM From frailty to resilience: exploring adaptive capacity and reserve in older adults-a narrative review Front Aging 2025 6 1520842 40665991 12259552 10.3389/fragi.2025.1520842
Tjeertes EKM Schmidt GB Mattace-Raso FUS Perioperative care of the geriatric patient Eur J Anaesthesiol 2026 43 93 102 40755208 10.1097/EJA.0000000000002257
Falvey JR Cohen AB O'Leary JR Leo-Summers L Murphy TE Ferrante LE Association of social isolation with disability burden and 1-year mortality among older adults with critical illness JAMA Intern Med 2021 181 1433 1439 34491282 8424527 10.1001/jamainternmed.2021.5022
Cecconi M Leaver S Jung C Caring for frail patients in the ICU: a multidimensional approach Intensive Care Med 2024 50 4 583 586 38498165 10.1007/s00134-024-07364-0
Grigoras G Ilie AC Turcu AM Albisteanu SM Lungu ID Stefaniu R Pislaru AI Gavrilovici O Alexa ID Resilience and intrinsic capacity in older adults: a review of recent literature J Clin Med 2025 14 21 7729 1:CAS:528:DC%2BB2MXivVOis7nJ 41227125 12608230 10.3390/jcm14217729
Cobert J Jeon SY Boscardin J Chapman AC Ferrante LE Lee S Smith AK Trends in geriatric conditions among older adults admitted to US ICUs between 1998 and 2015 Chest 2022 161 1555 1565 35026299 9248079 10.1016/j.chest.2021.12.658
Theou O Perez-Zepeda MU van der Valk AM Searle SD Howlett SE Rockwood K A classification tree to assist with routine scoring of the clinical frailty scale Age Ageing 2021 50 1406 1411 33605412 7929455 10.1093/ageing/afab006
Rockwood K Song X MacKnight C Bergman H Hogan DB McDowell I Mitnitski A A global clinical measure of fitness and frailty in elderly people CMAJ 2005 173 489 495 16129869 1188185 10.1503/cmaj.050051
Ferrante LE Szczeklik W Frailty is crucial in FORECASTing outcomes in critical care Intensive Care Med 2024 50 1119 1122 38953928 11556853 10.1007/s00134-024-07518-0
Jain S Han L Gahbauer EA Leo-Summers L Feder SL Ferrante LE Gill TM Association between restricting symptoms and disability after critical illness among older adults Crit Care Med 2024 52 1816 1827 1:CAS:528:DC%2BB2cXisFShtrjI 39298623 12019769 10.1097/CCM.0000000000006427
Ferrante LE Pisani MA Murphy TE Gahbauer EA Leo-Summers LS Gill TM Functional trajectories among older persons before and after critical illness JAMA Intern Med 2015 175 523 529 25665067 4467795 10.1001/jamainternmed.2014.7889
Fuest KE Lorenz M Grunow JJ Weiss B Morgeli R Finkenzeller S Bogdanski R Heim M Kapfer B Kriescher S Lingg C Martin J Ulm B Jungwirth B Blobner M Schaller SJ the functional trajectory in frail compared with non-frail critically Ill patients during the hospital stay Front Med (Lausanne) 2021 8 1:STN:280:DC%2BB2cflsl2hsw%3D%3D 34805218 8600066 10.3389/fmed.2021.748812 748812
Egodage T Patel PP One for the ages: optimizing geriatric care in the intensive care unit Trauma Surg Acute Care Open 2025 10 40521176 12164298 10.1136/tsaco-2025-001785 e001785
Mottale R Dupuis C Szklarzewska S Preiser JC The metabolic response to stress in critical illness: updated review on the pathophysiological mechanisms, consequences, and therapeutic implications Ann Intensive Care 2025 15 174 1:CAS:528:DC%2BB2MXjtF2kt7nK 41139771 12554859 10.1186/s13613-025-01588-z
Fuentes-Aspe R Gutierrez-Arias R Gonzalez-Seguel F Marzuca-Nassr GN Torres-Castro R Najum-Flores J Seron P Which factors are associated with acquired weakness in the ICU? An overview of systematic reviews and meta-analyses J Intensive Care 2024 12 33 39232808 11375885 10.1186/s40560-024-00744-0
Vanhorebeek I Latronico N Van den Berghe G ICU-acquired weakness Intensive Care Med 2020 46 637 653 32076765 7224132 10.1007/s00134-020-05944-4
Stollings JL Kotfis K Chanques G Pun BT Pandharipande PP Ely EW Delirium in critical illness: clinical manifestations, outcomes, and management Intensive Care Med 2021 47 1089 1103 1:CAS:528:DC%2BB3MXit1OitLrK 34401939 8366492 10.1007/s00134-021-06503-1
Herridge MS Azoulay E Outcomes after critical illness N Engl J Med 2023 388 913 924 1:CAS:528:DC%2BB3sXlsVGrsLg%3D 36884324 10.1056/NEJMra2104669
Herridge MS Chu LM Matte A Tomlinson G Chan L Thomas C Friedrich JO Mehta S Lamontagne F Levasseur M Ferguson ND Adhikari NK Rudkowski JC Meggison H Skrobik Y Flannery J Bayley M Batt J Santos CD Canadian Critical Care Trials G The RECOVER program: disability risk groups and 1-year outcome after 7 or more days of mechanical ventilation Am J Respir Crit Care Med 2016 194 831 844 26974173 10.1164/rccm.201512-2343OC
Ungar M Theron L Resilience and mental health: how multisystemic processes contribute to positive outcomes Lancet Psychiatry 2020 7 441 448 31806473 10.1016/S2215-0366(19)30434-1
Beil M Jacobs JM Guidet B The (un)surprising resilience of octogenarians in intensive care Intensive Care Med 2025 51 140 142 39774860 10.1007/s00134-024-07766-0
Shiotsuka J Masuyama T Uchino S Sasabuchi Y Suzuki R Ono S Yoshinaga K Iizuka Y Sanui M Utilization and outcomes of life-supporting interventions in older ICU patients in Japan: a nationwide registry study Intensive Care Med 2025 51 115 124 39774864 10.1007/s00134-024-07759-z
Maley JH Brewster I Mayoral I Siruckova R Adams S McGraw KA Piech AA Detsky M Mikkelsen ME Resilience in survivors of critical illness in the context of the survivors' experience and recovery Ann Am Thorac Soc 2016 13 1351 1360 27159794 5021076 10.1513/AnnalsATS.201511-782OC
Cobert J Jeon SY Boscardin J Chapman AC Espejo E Maley JH Lee S Smith AK Resilience, survival, and functional independence in older adults facing critical illness Chest 2024 166 1431 1441 38871280 10.1016/j.chest.2024.04.039
Kang J Lee MH Longitudinal trajectories of health-related quality of life among critical care survivors: a latent class growth approach Intensive Crit Care Nurs 2025 86 39522309 10.1016/j.iccn.2024.103892 103892
Smith BW Dalen J Wiggins K Tooley E Christopher P Bernard J The brief resilience scale: assessing the ability to bounce back Int J Behav Med 2008 15 194 200 18696313 10.1080/10705500802222972
Connor KM Davidson JR Development of a new resilience scale: the connor-davidson resilience scale (CD-RISC) Depress Anxiety 2003 18 76 82 12964174 10.1002/da.10113
Resnick B Galik E Dorsey S Scheve A Gutkin S Reliability and validity testing of the physical resilience measure Gerontologist 2011 51 643 652 21402647 10.1093/geront/gnr016
Hu FW Lin CH Yueh FR Lo YT Lin CY Development and psychometric evaluation of the physical resilience instrument for older adults (PRIFOR) BMC Geriatr 2022 22 229 35313802 8935854 10.1186/s12877-022-02918-7
Fried TR Tinetti ME Iannone L O'Leary JR Towle V Van Ness PH Health outcome prioritization as a tool for decision making among older persons with multiple chronic conditions Arch Intern Med 2011 171 1854 1856 21949032 4036681 10.1001/archinternmed.2011.424
Ferrante LE Murphy TE Leo-Summers LS O'Leary JR Vander Wyk B Pisani MA Gill TM Development and validation of a prediction model for persistent functional impairment among older ICU survivors J Am Geriatr Soc 2023 71 188 197 36196998 10.1111/jgs.18075
Fleurent-Gregoire C Burgess N McIsaac DI Chevalier S Fiore JF Jr Carli F Levett D Moore J Grocott MP Copeland R Edbrooke L Engel D Testa GD Denehy L Gillis C Towards a common definition of surgical prehabilitation: a scoping review of randomised trials Br J Anaesth 2024 133 305 315 38677949 11282475 10.1016/j.bja.2024.02.035
McIsaac DI MacDonald DB Aucoin SD Frailty for perioperative clinicians: a narrative review Anesth Analg 2020 130 6 1450 1460 32384334 10.1213/ANE.0000000000004602
Molenaar CJL Minnella EM Coca-Martinez M Ten Cate DWG Regis M Awasthi R Martinez-Palli G Lopez-Baamonde M Sebio-Garcia R Feo CV van Rooijen SJ Schreinemakers JMJ Bojesen RD Gogenur I van den Heuvel ER Carli F Slooter GD Effect of multimodal prehabilitation on reducing postoperative complications and enhancing functional capacity following colorectal cancer surgery: the PREHAB randomized clinical trial JAMA Surg 2023 158 6 572 581 36988937 10061316 10.1001/jamasurg.2023.0198
Berardi G Cucchetti A Colasanti M Angrisani M Moschetta G Chiappori D Marini A Antonelli G Ferretti S Meniconi RL Guglielmo N Mariano G Usai S Ettorre GM Prehabilitation with exercise and nutrition to reduce morbidity of major hepatectomy in patients with sarcopenia: the PREHEP randomized clinical trial JAMA Surg 2025 160 10 1068 1075 40864449 12392143 10.1001/jamasurg.2025.3102
Cho AR Najafi T Ramanakumar AV Ferri L Spicer J Najmeh S Cools-Lartigue J Sirois C Soh S Kim DJ Carli F The effect of multimodal prehabilitation on postoperative outcomes in lung cancer surgery J Thorac Cardiovasc Surg 2025 169 1631–1644 e1632
Brat K Sova M Homolka P Plutinsky M Genzor S Pokorna A Dosbaba F Imrichova B Chovanec Z Mitas L Mikulaskova M Svoboda M Olson L Cundrle I study g Multimodal prehabilitation before lung resection surgery: a multicentre randomised controlled trial Br J Anaesth 2025 135 188 196 40374400 12597589 10.1016/j.bja.2025.03.018
McIsaac DI Kidd G Gillis C Branje K Al-Bayati M Baxi A Grudzinski AL Boland L Veroniki AA Wolfe D Hutton B Relative efficacy of prehabilitation interventions and their components: systematic review with network and component network meta-analyses of randomised controlled trials BMJ 2025 10.1136/bmj-2024-081164 39843215 11752451
Cambriel A Tsai A Choisy B Sabayev M Hedou J Shelton E Singh K Amar J Badea V Bruckman S Ganio E Einhaus J Feyaerts D Stelzer I Sato M Langeron O Bonham TA Gaudilliere D Shelton A Verdonk F Immune modulation by personalized vs standard prehabilitation before major surgery: a randomized clinical trial JAMA Surg 2026 161 1 20 30 41222945 12613092 10.1001/jamasurg.2025.4917
Coca-Martinez M Carli F Prehabilitation: who can benefit? Eur J Surg Oncol 2024 50 37451924 10.1016/j.ejso.2023.07.005 106979
Minnella EM Awasthi R Gillis C Fiore JF Jr Liberman AS Charlebois P Stein B Bousquet-Dion G Feldman LS Carli F Patients with poor baseline walking capacity are most likely to improve their functional status with multimodal prehabilitation Surgery 2016 160 1070 1079 27476586 10.1016/j.surg.2016.05.036
Carli F Bousquet-Dion G Fiore JF Jr Prehabilitation vs postoperative rehabilitation for frail patients JAMA Surg 2020 155 3 233 242 31968063 6990653 10.1001/jamasurg.2019.5474
McIsaac DI Lee S Fergusson D Gillis C Khadaroo RG Meliambro A Muscedere J Eskander A Moloo H Nelson G Saha T Chun R Serrano PE Wijeysundera DN Taljaard M Barnes K Boet S Boland L Branje K Yang I Home-based prehabilitation for older surgical patients with frailty: a randomized clinical trial JAMA Surg 2026 161 2 113 123 41335421 12676472 10.1001/jamasurg.2025.5288
McIsaac DI Hladkowicz E Bryson GL Forster AJ Gagne S Huang A Lalu M Lavallee LT Moloo H Nantel J Power B Scheede-Bergdahl C van Walraven C McCartney CJL Taljaard M Home-based prehabilitation with exercise to improve postoperative recovery for older adults with frailty having cancer surgery: the PREHAB randomised clinical trial Br J Anaesth 2022 129 41 48 35589429 10.1016/j.bja.2022.04.006
Sun Y Tian Y Cao S Li L Yu W Ding Y Wang X Kong Y Wang X Wang H Hui X Qu J Wang H Duan Q Yang D Zhang H Zhou S Liu X Li Z Zhou Y Supervised multimodal prehabilitation and clinical outcomes in older patients with frailty and gastric cancer: the GISSG+2201 randomized clinical trial JAMA Surg 2026 161 223 233 41604182 12853284 10.1001/jamasurg.2025.6256
Humeidan ML Reyes JC Mavarez-Martinez A Roeth C Nguyen CM Sheridan E Zuleta-Alarcon A Otey A Abdel-Rasoul M Bergese SD Effect of cognitive prehabilitation on the incidence of postoperative delirium among older adults undergoing major noncardiac surgery: the neurobics randomized clinical trial JAMA Surg 2021 156 2 148 156 33175114 7658803 10.1001/jamasurg.2020.4371
Barnes K Hladkowicz E Dorrance K Bryson GL Forster AJ Gagne S Huang A Lalu MM Lavallee LT Saunders C Moloo H Nantel J Power B Scheede-Bergdahl C Taljaard M van Walraven C McCartney CJL McIsaac DI Barriers and facilitators to participation in exercise prehabilitation before cancer surgery for older adults with frailty: a qualitative study BMC Geriatr 2023 23 1 356 37280523 10242997 10.1186/s12877-023-03990-3
Kimura C Liu Y Crowder SE Arbaugh C Mai U Shankar K Shelton A Visser B Kin C Barriers and facilitators of surgical prehabilitation adherence from the patient perspective: a mixed method study J Gastrointest Surg 2023 27 11 2547 2556 37848690 10.1007/s11605-023-05857-9
Liu T Balde D Edgar L Carli F Prehabilitation for surgical cancer patients: an active role for the caregiver? Eur J Surg Oncol 2025 51 40857983 10.1016/j.ejso.2025.110391 110391
Gao W Jin J Expanding the scope of prehabilitation: reducing critical illness weakness across elective surgical patients scheduled for postoperative ICU care Crit Care 2024 28 1 3 38169401 10759686 10.1186/s13054-023-04784-0
Ke Y Tay VY Leong YH Tan CJ Au-Yong PS Sim JX Nithiyananthan M Jin L Ng RR Eng MH Abdullah HR The role of wearable technology in home-based prehabilitation: a scoping review Br J Anaesth 2025 134 228 231 39505592 10.1016/j.bja.2024.09.024
Buckinx F Rousseau AF Louis E De Roover A Detry O Durieux R Gillain S Kaba A Kaux JF Tchana-Sato V Bruyere O Effects of prehabilitation programmes on postoperative outcomes in older adults undergoing major abdominal, cardiac or vascular surgery: a systematic review Aging Clin Exp Res 2026 10.1007/s40520-025-03314-y 41935176
Kotfis K Kress JP Slooter AJC Delirium versus encephalopathy: a call for precise terminology Intensive Care Med 2025 10.1007/s00134-025-08124-4 41117946
Noda K Koga M Toyoda K Recognition of strokes in the ICU: a narrative review J Cardiovasc Dev Dis 2023 10 4 182 37103061 10145112
Bassi T Taran S Girard TD Robba C Goligher EC Ventilator-associated brain injury: a new priority for research in mechanical ventilation Am J Respir Crit Care Med 2024 209 1186 1188 38526447 11146544 10.1164/rccm.202401-0069VP
Teppa-Zyl R Damiani LF Munoz-Cofre R Carmona-Valenzuela C Marzuca-Nassr GN Skeletal muscle mass, strength, and functional status in critically Ill older adults aged 60–75 and over 80 years old: an exploratory study Healthcare (Basel) 2026 14 5 585 41827539 12984329 10.3390/healthcare14050585
Rubinos C Ruland S Neurologic complications in the intensive care unit Curr Neurol Neurosci Rep 2016 10.1007/s11910-016-0651-8 27098953
Tawfik GA Lu M De La Hoz M Crugnola W Jin Z Moller D Molecular and clinical considerations for anesthesia in the aging brain Int J Mol Sci 2025 26 21 10272 1:CAS:528:DC%2BB2MXivVCitb%2FF 41226311 12610017 10.3390/ijms262110272
Pandin P Estruc I Van Hecke D Truong HN Marullo L Hublet S Van Obbergh L Brain aging and anesthesia J Cardiothorac Vasc Anesth 2019 33 Suppl 1 S58 S66 31279354 10.1053/j.jvca.2019.03.042
Van Hollebeke M Shi Z Dres M Ventilator-induced brain injury: another iatrogenic complication of mechanical ventilation Curr Opin Crit Care 2026 10.1097/mcc.0000000000001347 41319124
Badenes R Romero-Garcia N Marshall TJ The perioperative brain: navigating neurological risks in non-neurosurgical patients Intensive Care Med 2026 10.1007/s00134-026-08299-4 41661295
Sonneville R Benghanem S Jeantin L de Montmollin E Doman M Gaudemer A Thy M Timsit JF The spectrum of sepsis-associated encephalopathy: a clinical perspective Crit Care 2023 27 1 386 37798769 10552444 10.1186/s13054-023-04655-8
Battaglini D Pelosi P Robba C The importance of neuromonitoring in non brain injured patients Crit Care 2022 10.1186/s13054-022-03914-4 36527126 9758928
Goldfarb M Afilalo J Chan A Herscovici R Cercek B Early mobility in frail and non-frail older adults admitted to the cardiovascular intensive care unit J Crit Care 2018 47 9 14 29879568 10.1016/j.jcrc.2018.05.013
Fuest KE Ulm B Daum N Lindholz M Lorenz M Blobner K Langer N Hodgson C Herridge M Blobner M Schaller SJ Clustering of critically ill patients using an individualized learning approach enables dose optimization of mobilization in the ICU Crit Care 2023 27 1 1 36597110 9808956 10.1186/s13054-022-04291-8
Broadley T Serpa Neto A Bailey M Bellomo R Brickell K Buhr H Gabbe BJ Gould DW Harrold M Hurford S Iwashyna TJ Nichol AD Presneill JJ Schaller SJ Sivasuthan J Tipping CJ Webb S Young PJ Higgins AM Investigators TT Adverse events during and after early mobilisation: a post hoc analysis of the TEAM trial Aust Crit Care 2025 38 101156 39826257 10.1016/j.aucc.2024.101156
Fadeur M Preiser JC Verbrugge AM Misset B Rousseau AF Oral nutrition during and after critical illness: SPICES for quality of care! Nutrients 2020 12 11 3509 33202634 7696881 10.3390/nu12113509
Rolfsen ML Boncyk C Owens RL Ely EW Optimal sedation in older critically Ill adults Crit Care Clin 2025 41 735 752 41101835 10.1016/j.ccc.2025.05.003
Holm A Thorn L Alro AB Nedergaard HK Jensen HI Dreyer P Non-pharmacological interventions to support the cognitive rehabilitation of patients admitted to the intensive care unit: an umbrella review Nurs Crit Care 2025 30 3 e13190 39503063 10.1111/nicc.13190
Marra A Ely EW Pandharipande PP Patel MB The ABCDEF bundle in critical care Crit Care Clin 2017 33 225 243 28284292 5351776 10.1016/j.ccc.2016.12.005
Vincent JL Shehabi Y Walsh TS Pandharipande PP Ball JA Spronk P Longrois D Strom T Conti G Funk GC Badenes R Mantz J Spies C Takala J Comfort and patient-centred care without excessive sedation: the eCASH concept Intensive Care Med 2016 42 962 971 1:CAS:528:DC%2BC28XmsFCjs7g%3D 27075762 4846689 10.1007/s00134-016-4297-4
Cai Y Ren X Ding C Impacts of non-pharmacological interventions on post-intensive care syndrome: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials Intensive Crit Care Nurs 2026 93 104326 41481952 10.1016/j.iccn.2025.104326
Alqurain A Ali AO Abdelhamid TA Abdulrahman D Syoty M Alahmari A Alrumaih F Soliman KAR Interventions to prevent or mitigate post-intensive care syndrome (PICS) in adult ICU survivors: a systematic review and network meta-analysis Cureus 2026 18 e104033 41883924 13009262
Kaushik R Ferrante LE Long-term recovery after critical illness in older adults Curr Opin Crit Care 2022 28 5 572 580 35950731 9458622
Spies CD Krampe H Paul N Denke C Kiselev J Piper SK Kruppa J Grunow JJ Steinecke K Gulmez T Scholtz K Rosseau S Hartog C Busse R Caumanns J Marschall U Gersch M Apfelbacher C Weber-Carstens S Weiss B Instruments to measure outcomes of post-intensive care syndrome in outpatient care settings - results of an expert consensus and feasibility field test J Intensive Care Soc 2021 22 159 174 34025756 10.1177/1751143720923597
Nakanishi N Liu K Kawauchi A Okamura M Tanaka K Katayama S Mitani Y Ota K Taito S Fudeyasu K Masuka Y Yoshihiro S Utsumi S Nishikimi M Masuda M Iida Y Kawai Y Hatakeyama J Hifumi T Nishida O Instruments to assess post-intensive care syndrome assessment: a scoping review and modified Delphi method study Crit Care 2023 27 430 37936249 10629074 10.1186/s13054-023-04681-6
Pant U Vyas K Meghani S Park T Norris CM Papathanassoglou E Screening tools for post-intensive care syndrome and post-traumatic symptoms in intensive care unit survivors: a scoping review Aust Crit Care 2023 36 863 871 36464526 10.1016/j.aucc.2022.09.007
Beil M Alberto L Bourne RS Brummel NE de Groot B de Lange DW Elbers P Emmelot-Vonk M Flaatten H Freund Y Galazzi A Garcia-Martinez A Guidet B Holmerova I Jacobs JM Joynt GM Leaver S Leone M McNicholas B Jung C ESICM consensus-based recommendations for the management of very old patients in intensive care Intensive Care Med 2025 51 287 301 39961851 10.1007/s00134-025-07794-4
Scheunemann LP White JS Prinjha S Hamm ME Girard TD Skidmore ER Reynolds CF 3rd Leland NE Post-intensive care unit care. a qualitative analysis of patient priorities and implications for redesign Ann Am Thorac Soc 2020 17 221 228 31726016 6993800 10.1513/AnnalsATS.201904-332OC
Bourne RS Alberto L Brummel NE de Groot B De Lange DW Elbers P Emmelot-Vonk MH Flaatten H Freund Y Galazzi A Garcia-Martinez A Guidet B Holmerova I Jacobs JM Joynt GM Leaver S Leone M McNicholas B McWilliams D Beil M Understanding barriers and facilitators to implementation of consensus-based recommendations for the management of very old people in intensive care Age Ageing 2025 54 9 afaf272 41004134 10.1093/ageing/afaf272
Vallet H Arai H Jacobs JM Bridging the gap: improving the long-term management of very old patients in intensive care Eur Geriatr Med 2025 16 3 749 751 40221953 10.1007/s41999-025-01190-3
Haines KJ Hibbert E Leggett N Boehm LM Hall T Bakhru RN Bastin AJ Butcher BW Eaton TL Harris W Hope AA Jackson J Johnson A Kloos JA Korzick KA Mactavish P Meyer J Montgomery-Yates A Quasim T Society of Critical Care Medicine’s Thrive i Transitions of care after critical illness-challenges to recovery and adaptive problem solving Crit Care Med 2021 49 11 1923 1931 34091486 8516700 10.1097/CCM.0000000000005095
Jacobs JM Rahamim A Beil M Guidet B Vallet H Flaatten H Leaver SK de Lange D Szczeklik W Jung C Sviri S Critical care beyond organ support: the importance of geriatric rehabilitation Ann Intensive Care 2024 14 1 71 38727919 11087448 10.1186/s13613-024-01306-1
Leggett N Emery K Rollinson TC Deane A French C Manski Nankervis JA Eastwood G Miles B Merolli M Ali Abdelhamid Y Haines KJ Fragmentation of care between intensive and primary care settings and opportunities for improvement Thorax 2023 78 1181 1187 37620046 10.1136/thorax-2023-220387
Gustafson O Dalton R Thurley N Pattison N Bedford J Watkinson P Vollam S Non-pharmacological post-intensive care interventions to improve patient outcome following critical illness: a scoping review Crit Care 2025 10.1186/s13054-025-05755-3 41316422 12764170