[en] Thiamine (vitamin B1) is an essential molecule for all living organisms. It is the precursor for several phosphorylated derivatives, the
most important being the coenzyme thiamine diphosphate (ThDP). Thiamine is transported into cells by specific transporters and
pyrophosphorylated to ThDP in the cytosol. ThDP is an essential cofactor for cellular oxidative energy metabolism. Thiamine deficiency
disorders, which lead to severe nervous system lesions and cardiac failure, are still common either as a consequence of chronic and severe
alcoholism, nutritional thiamine deficiency. Recent research suggests that synthetic thiamine precursor with high bioavailabity could
become interesting therapeutic tools in neurodegenerative diseases. The aim of the present chapter is to summarize recent developments
in the field with special focus on nutrition.
Research Center/Unit :
GIGA Neurosciences-Neurophysiology - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Bettendorff, Lucien ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique
Language :
English
Title :
Thiamine: Properties, Physiology, and Health Effects
