Profil

Bettendorff Lucien

GIGA Neurosciences - Neurophysiology

Département des sciences biomédicales et précliniques

Biochimie et physiologie humaine et pathologique

See author's contact details
ORCID
0000-0002-2826-6789
Main Referenced Co-authors
Wins, Pierre (55)
Lakaye, Bernard  (27)
Schoffeniels, Ernest (24)
Grandfils, Christian  (21)
Grisar, Thierry  (19)
Main Referenced Keywords
thiamine (39); Thiamine (25); thiamine triphosphate (12); Benfotiamine (9); thiamine triphosphatase (8);
Main Referenced Unit & Research Centers
Giga Neurosciences - ULiège [BE] (51)
CEIB - Centre Interfacultaire des Biomatériaux - ULiège [BE] (13)
GIGA Neurosciences-Neurophysiology - ULiège [BE] (2)
Giga-Systems Biology and Chemical Biology - ULiège [BE] (2)
BMB/CNPRC, University of CA, Davis (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (162)
Neurosciences & behavior (3)
Oncology (2)
Pharmacy, pharmacology & toxicology (2)
Human health sciences: Multidisciplinary, general & others (2)

Publications (total 178)

The most downloaded
1291 downloads
Hills, J. I., Golub, M. S., Bettendorff, L., & Keen, C. L. (2012). The effect of thiamin tetrahydrofurfuryl disulfide on behavior of juvenile DBA/2J mice. Neurotoxicology and Teratology, 34, 242-252. doi:10.1016/j.ntt.2011.07.006 https://hdl.handle.net/2268/97164

The most cited

184 citations (Scopus®)

Whitfield, K. C., Bourassa, M. W., Adamolekun, B., Bergeron, G., Bettendorff, L., Brown, K. H., Cox, L., Fattal-Valevski, A., Fischer, P. R., Frank, E. L., Hiffler, L., Hlaing, L. M., Jefferds, M. E., Kapner, H., Kounnavong, S., Mousavi, M. P. S., Roth, D. E., Tsaloglou, M.-N., Wieringa, F., & Combs, G. F. J. (2018). Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs. Annals of the New York Academy of Sciences, 1430, 3-43. doi:10.1111/nyas.13919 https://hdl.handle.net/2268/227352

Bettendorff, L. (10 July 2023). Synthetic Thioesters of Thiamine: Promising Tools for Slowing Progression of Neurodegenerative Diseases. International Journal of Molecular Sciences, 24, 11296. doi:10.3390/ijms241411296
Peer Reviewed verified by ORBi

Bettendorff, L. (01 November 2022). Neuroprotective effects of thiamine and precursors with higher bioavailability: focus on benfotiamine and dibenzoylthiamine [Paper presentation]. Paper presented at invited conference at the Burke Neurological Institute (Cornell University), White Plains,New York, United States.

Probert, F., Gorlova, A., Deikin, A., Bettendorff, L., Veniaminova, E., Nedorubov, A., Chaprov, K. D., Ivanova, T. A., Anthony, D. C., & Strekalova, T. (November 2022). In FUS[1−359]‐tg mice O,S-dibenzoyl thiamine reduces muscle atrophy, decreases glycogen synthase kinase 3 beta, and normalizes the metabolome. Biomedicine and Pharmacotherapy, 156, 113986. doi:10.1016/j.biopha.2022.113986
Peer Reviewed verified by ORBi

Bettendorff, L. (September 2022). Reduced Nucleotides, Thiols and O2 in Cellular Redox Balance: a Biochemist’s View. Antioxidants, 11, 1877. doi:10.3390/antiox11101877
Peer Reviewed verified by ORBi

Sambon, M., Pavlova, O., Alhama-Riba, J., Wins, P., Brans, A., & Bettendorff, L. (2022). Product inhibition of mammalian thiamine pyrophosphokinase is an important mechanism for maintaining thiamine diphosphate homeostasis. Biochimica et Biophysica Acta - General Subjects, 1866 (3), 130071. doi:10.1016/j.bbagen.2021.130071
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Bettendorff, L., & Wins, P. (2021). Biochemistry of thiamine and thiamine phosphate compounds. In J. Jez (Ed.), Encyclopedia of Biological Chemistry, 3rd Edition, vol 1 (pp. 302-313). Elsevier. doi:10.1016/B978-0-12-809633-8.21271-5
Peer reviewed

Pavlova, O., Stepanenko, S., Chehivska, L., Sambon, M., Bettendorff, L., & Parkhomenko, Y. (2021). Thiamine deficiency in rats affects thiamine metabolism possibly through the formation of oxidized thiamine pyrophosphate. Biochimica et Biophysica Acta - General Subjects, 1865, 129980. doi:10.1016/j.bbagen.2021.129980
Peer Reviewed verified by ORBi

Bettendorff, L. (2021). Update on Thiamine Triphosphorylated Derivatives and Metabolizing Enzymatic Complexes. Biomolecules, 11, 1645. doi:10.3390/biom11111645
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Sambon, M., Wins, P., & Bettendorff, L. (2021). Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine. International Journal of Molecular Sciences, 22, 5418. doi:10.3390/ijms22115418
Peer Reviewed verified by ORBi

Bettendorff, L. (2020). Chapter 10: Thiamine. In B. P. Marriott, D. F. Birt, V. A. Stallings, ... A. A. Yares, Present Knowledge in Nutrition, 11th Edition, volume 1 (11th Edition). Amsterdam, Netherlands: Elsevier.
Peer reviewed

Pavlov, D., Gorlova, A., Bettendorff, L., Kalueff, A. A., Umriukhin, A., Proshin, A., Lysko, A., Landgraf, R., Anthony, D. C., & Strekalova, T. (20 April 2020). Enhanced conditioning of adverse memories in the mouse modified swim test is associated with neuroinflammatory changes - effects that are susceptible to antidepressants. Neurobiology of Learning and Memory, 172, 107227. doi:10.1016/j.nlm.2020.107227
Peer Reviewed verified by ORBi

Starling-Soares, B., Carrera-Bastos, P., & Bettendorff, L. (April 2020). The role of the synthetic B1 Vitamin sulbutiamine on health - a review. Journal of Nutrition and Metabolism, 2020 (Article ID 9349063), 1-9. doi:10.1155/2020/9349063
Peer Reviewed verified by ORBi

Veniaminova, E., Oplatchikova, M., Bettendorff, L., Kotenkova, E., Lysko, A., Vasilevskaya, E., Kalueff, A. V., Fedulova, L., Umriukhin, A., Lesch, K.-P., Anthony, D. C., & Strekalova, T. (2020). Prefrontal cortex inflammation and liver pathologies accompany cognitive T and motor deficits following Western diet consumption in non-obese female mice. Life Sciences, 241, 117163. doi:10.1016/j.lfs.2019.117163
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Gibson, G. E., Luchsinger, J. A., Cirio, R., Chen, H., Franchino-Elder, J., Hirsch, J. A., Bettendorff, L., Chen, Z., Flowers, S., Gerber, L., Grandville, T., Schupf, N., Xu, H., Stern, Y., Habeck, C., Jordan, B., & Fonzetti, P. (2020). Benfotiamine and cognitive decline in Alzheimer’s disease: Results of a randomized placebo-controlled phase IIa clinical trial. Journal of Alzheimer's Disease, 78, 989-1010. doi:10.3233/JAD-200896
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Sambon, M., Gorlova, A., Demelenne, A., Alhama-Riba, J., Coumans, B., Lakaye, B., Wins, P., Fillet, M., Anthony, D. C., Strekalova, T., & Bettendorff, L. (2020). Dibenzoylthiamine has powerful antioxidant and anti-inflammatory properties in cultured cells and in mouse models of stress and neurodegeneration. Biomedicines, 8, 361. doi:10.3390/biomedicines8090361
Peer Reviewed verified by ORBi

Mouithys-Mickalad, A., Ceusters, J., Charif, M., Elmoualij, B., Schoumacher, M., Plyte, S., Franck, T., Bettendorff, L., Pirotte, B., Serteyn, D., & De Tullio, P. (2020). Modulation of mitochondrial respiration rate and calcium-induced swelling by new cromakalim analogues. Chemico-Biological Interactions, 331, 109272. doi:10.1016/j.cbi.2020.109272
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Bettendorff, L. (20 August 2019). Current status of research on thiamine: anti-neuroinflammatory and anti-oxidant properties yield new therapeutic perspectives [Paper presentation]. Conférence au “Symposium and Workshop on “Inflammation and oxidative stress in translational research: new models and treatments”.
Editorial reviewed

Pavlov, D., Bettendorff, L., Gorlova, A., Olkhovik, A., Kalueff, A., Ponomarev, E., Inozemtsev, A., Chekhonin, V., Lesch, K.-P., Anthony, D. C., & Strekalova, T. (2019). Neuroinflammation and aberrant hippocampal plasticity in a mouse model of emotional stress evoked by exposure to ultrasound of alternating frequencies. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 90, 104-116. doi:10.1016/j.pnpbp.2018.11.014
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Gorlova, A., Pavlov, D., Anthony, D. C., Ponomarev, E., Sambon, M., Shafarevich, I., Babaevskaya, D., Proshin, A., Lesch, K.-P., Bettendorff, L., & Strekalova, T. (2019). Thiamine and benfotiamine counteract stress-induced aggression, normalize AMPA receptor expression and plasticity markers, and reduce oxidative stress in mice. Neuropharmacology, 156, 107543. doi:10.1016/j.neuropharm.2019.02.025
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Sambon, M., NAPP, A., Demelenne, A., Vignisse, J., Wins, P., Fillet, M., & Bettendorff, L. (2019). Thiamine and benfotiamine protect neuroblastoma cells against paraquat and ß- amyloid toxicity by a coenzyme-independent mechanism. Heliyon, 5, 01710. doi:10.1016/j.heliyon.2019.e01710
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Bakker, J., Balthazart, J., Baron, F., Beguin, Y., Bettendorff, L., Blanpain, C., Bureau, F., Caers, J., Cani, P., Cataldo, D., Cornil, C., Clercx, C., Cloots, R., Colige, A., Daube, G., De Backer, O., de Kerchove d'Exaerde, A., Desmecht, D., Desmet, C., ... Wittamer, V. (2018). La souris, le patient, et le faux expert. Décryptage d'une mystification. Le Vif. L'Express.

Rademaker, G., Hennequière, V., Nokin, M.-J., LOVINFOSSE, P., Durieux, F., GOFFLOT, S., Bellier, J., Costanza, B., Herfs, M., Peiffer, R., Bettendorff, L., Deroanne, C., Thiry, M., Delvenne, P., Hustinx, R., Bellahcene, A., Castronovo, V., & Peulen, O. (April 2018). Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness. Oncogene, 37 ((32)), 4398-4412. doi:10.1038/s41388-018-0287-z
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Rademaker, G., Hennequière, V., Brohée, L., Nokin, M.-J., LOVINFOSSE, P., Durieux, F., Bellier, J., Costanza, B., Herfs, M., Bettendorff, L., Deroanne, C., Delvenne, P., HUSTINX, R., Bellahcene, A., Castronovo, V., & Peulen, O. (2018). Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma and affects tumor aggressiveness [Poster presentation]. Bioforum Uliège.

Tapias, V., Jainuddin, S., Ahuja, M., Stack, C., Elipenahli, C., Vignisse, J., Gerges, M., Starkova, N., Xu, H., Starkov, A. A., Bettendorff, L., Hushpulian, D. M., Smirnova, N. A., Gazaryan, I. G., Kaidery, N. A., Wakade, S., Calingasan, N. Y., Thomas, B., Gibson, G. E., ... Beal, M. F. (2018). Benfotiamine Treatment Activates the Nrf2/ARE Pathway and is Neuroprotective in a Transgenic Mouse Model of Tauopathy. Human Molecular Genetics, 27 (16), 2874-2892. doi:10.1093/hmg/ddy201
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Rademaker, G., Hennequière, V., Brohée, L., Nokin, M.-J., LOVINFOSSE, P., Durieux, F., GOFFLOT, S., Bellier, J., Costanza, B., Herfs, M., Peiffer, R., Anania, S., Bettendorff, L., Deroanne, C., Thiry, M., Delvenne, P., HUSTINX, R., Bellahcene, A., Castronovo, V., & Peulen, O. (2018). Myoferlin controls mitochondrial structure and activity in pancreatic cancer and affects tumor aggressiveness [Poster presentation]. Belgian Association for Cancer Research Congress.

Whitfield, K. C., Bourassa, M. W., Adamolekun, B., Bergeron, G., Bettendorff, L., Brown, K. H., Cox, L., Fattal-Valevski, A., Fischer, P. R., Frank, E. L., Hiffler, L., Hlaing, L. M., Jefferds, M. E., Kapner, H., Kounnavong, S., Mousavi, M. P. S., Roth, D. E., Tsaloglou, M.-N., Wieringa, F., & Combs, G. F. J. (2018). Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs. Annals of the New York Academy of Sciences, 1430, 3-43. doi:10.1111/nyas.13919
Peer Reviewed verified by ORBi

Amorim, C., Andris, F., Arckens, L., Arnould, T., Aron, S., Bakker, J., Balligand, M., Balthazart, J., Baron, F., Beck, B., Beguin, Y., Behets, C., Bellefroid, E., Bertrand, L., Bettendorff, L., Bindels, L., Blankert, B., Blanpain, C., Bondue, A., ... Wittamer, V. (2017). L’expérimentation animale reste indispensable (OPINION). La Libre Belgique.

Rademaker, G., Hennequière, V., Brohée, L., Nokin, M.-J., LOVINFOSSE, P., Durieux, F., GOFFLOT, S., Bellier, J., Costanza, B., Herfs, M., Peiffer, R., Bettendorff, L., Deroanne, C., Delvenne, P., Hustinx, R., Bellahcene, A., Castronovo, V., & Peulen, O. (22 September 2017). Myoferlin controls mitochondrial structure in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness [Poster presentation]. Second U-CRC Symposium, Bruxelles, Belgium.

Hendrick, E., Peixoto, P., Blomme, A., Polese, C., Matheus, N., Cimino, J., Frère, A., Mouithys-Mickalad, A., Serteyn, D., Bettendorff, L., Elmoualij, B., De Tullio, P., Eppe, G., Dequiedt, F., Castronovo, V., & Mottet, D. (2017). Metabolic inhibitors accentuate the anti-tumoral effect of HDAC5 inhibition. Oncogene. doi:10.1038/onc.2017.103
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Bettendorff, L. (26 January 2017). Thiamine, biological forms and function [Paper presentation]. Technical Consultation on Global Prevalence and Disease Burden of Thiamine Deficiency – Workshop 1, New York, United States.

Bettendorff, L. (2017). Thiamine: Biological forms and function [Paper presentation]. Technical consultation on global prevalence and disease burden of thiamine deficiency - workshop 1, New York, United States.

Vignisse, J., Sambon, M., Gorlova, A., Pavlov, D., Caron, N., Malgrange, B., Shevtsova, E., Svistunov, A., Anthony, D. C., Markova, N., Bazhenova, N., Coumans, B., Lakaye, B., Wins, P., Strekalova, T., & Bettendorff, L. (2017). Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels. Molecular and Cellular Neuroscience, 82, 126-136. doi:10.1016/j.mcn.2017.05.005
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Markova, N.* , Bazhenova, N.* , Anthony, D. C., Vignisse, J., Svistunov, A., Lesch, K.-P., Bettendorff, L.* , & Strekalova, T.*. (2017). Thiamine and benfotiamine improve cognition and ameliorate GSK-3β-associated stressinduced behaviours in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 75, 148-156. doi:10.1016/j.pnpbp.2016.11.001
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* These authors have contributed equally to this work.

Tapias, V., Jainuddin, S., Ahuja, M., Stack, C., Elipenahli, C., Vignisse, J., Gerges, M., Starkova, N., Xu, H., Starkov, A. A., Bettendorff, L., Hushpulian, D. M., Smirnova, N. A., Gazaryan, I. G., Kaidery, N. A., Wakade, S., Calingasan, N. Y., Thomas, B., Gibson, G. E., ... Beal, F. M. (2017). Benfotiamine Treatment Activates Nrf2/ARE Pathway and is Neuroprotective in a Transgenic Mouse Model of Tauopathy [Poster presentation]. 47th Annual Meeting 2017 of the Society for Neuroscience, Washington DC, United States.

Markova, N., Shevtsova, S., Vignisse, J., Zubareva, O., Anthony, D., Bettendorff, L., Lesch, K., & Strekalova, T. (2017). Modified swim test as a model of enhanced contextual conditioning during depression: expression of GSK3 beta and effects of antidepressant treatment [Poster presentation]. 12th Göttingen Meeting of the German Neuroscience Society, Göttingen, Germany.

Pavlov, D., Markova, N., Bettendorff, L., Chekhonin, V., Pomytkin, I., Lioudyno, V., Svistunov, A., Ponomarev, E., Lesch, K.-P., & Strekalova, T. (2017). Elucidating the functions of brain GSK3α: possible synergy with GSK3β upregulation and reversal by antidepressant treatment in a mouse model of depressive-like behaviour. Behavioural Brain Research, 335, 122-127. doi:10.1016/j.bbr.2017.08.018
Peer Reviewed verified by ORBi

Sambon, M., Wins, P., & Bettendorff, L. (2017). Dibenzoylthiamine, a lipophilic thiamine precursor, protects against oxidative damage in neuroblastoma cells [Poster presentation]. ISN-ESN Biennal Meeting, Paris, France.

Sambon, M., Wins, P., & Bettendorff, L. (2017). Thiamine and lipophilic thiamine precursors protect against oxidative damage in cultured neuroblastoma cells [Poster presentation]. 12th National Congress of the Belgian Society for Neuroscience, Ghent, Belgium. doi:10.3389/conf.fnins.2017.94.00102

Bunik, V., Mkrtchyan, G., Grabarska, A., Oppermann, H., Daloso, D., Araujo, W. L., Juszczak, M., Rzeski, W., Bettendorff, L., Fernie, A. R., Meixensberger, J., Stepulak, A., & Gaunitz, F. (March 2016). Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolismdependent manner. Oncotarget, 7 (26400), 26421. doi:10.18632/oncotarget.8387
Peer Reviewed verified by ORBi

Mkrtchyan, G., Graf, A., Bettendorff, L., & Bunik, V. (2016). Cellular thiamine status is coupled to function of mitochondrial 2-oxoglutarate dehydrogenase. Neurochemistry International, 101, 66-75. doi:10.1016/j.neuint.2016.10.009
Peer Reviewed verified by ORBi

Mkrtchyan, G., Aleshin, V., Parkhomenko, Y., Kaehne, T., Di Salvo, M. L., Parroni, A., Contestabile, R., Vovk, A., Bettendorff, L., & Bunik, V. (2015). Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis. Scientific Reports, 5, 12583. doi:10.1038/srep12583
Peer Reviewed verified by ORBi

Bettendorff, L., Lakaye, B., Kohn, G., & Wins, P. (25 May 2014). In search of a physiological role for thiamine triphosphate and the 25-kDa thiamine triphosphatase [Paper presentation]. 8th International Conference on Thiamine: From Catalysis to Pathology, Liège, Belgium.

Markova, N., Shevtsova, E., Vignisse, J., Zubareva, O., Trofimov, A., Steinbusch, H., Bachurin, S., Bettendorff, L., & Strekalova, T. (May 2014). Thiamine and benfotiamine improve memory, decrease depressive-like behavior and reduce brain expression of GSK3 beta in mice [Poster presentation]. 8th International Conference on Thiamine: From Catalysis to Pathology, Liège, Belgium.

Vignisse, J., Caron, N., Malgrange, B., & Bettendorff, L. (May 2014). Benfotiamine increases cell proliferation in adult mouse hippocampus [Poster presentation]. 8th International Conference on Thiamine: From Catalysis to Pathology, Liège, Belgium.

Kohn, G., Ectors, F., Lakaye, B., & Bettendorff, L. (May 2014). 25KDa-Thiamine triphosphatase is essential for spermatozoid development in mice [Poster presentation]. 8th International Conference on Thiamine: From Catalysis to Pathology, Liège, Belgium.

Vignisse, J., Steinbusch, H. W. M., Grigoriev, V., Bolkunov, A., Prochin, A., Bettendorff, L., Bachurin, S., & Strekalova, T. (2014). Concomitant manipulation of NMDA- and AMPA-receptors to produce pro-cognitive drug effects. European Neuropsychopharmacology, 24, 309-320. doi:10.1016/j.euroneuro.2013.06.010
Peer Reviewed verified by ORBi

Bettendorff, L. (2014). Chapter 7: Thiamine. In J. Zemplini, J. W. Suttie, J. F. Gregory, ... P. J. Stover (Eds.), Handbook of Vitamins, 5th Edition (5th Edition, pp. 267-323). CRC Press Taylor & Francis Group.
Peer reviewed

Bettendorff, L., & Wins, P. (2014). Thiamine triphosphate: a ubiquitous molecule in search of a physiological role. Metabolic Brain Disease, 29, 1069-1082. doi:10.1007/s11011-014-9509-4
Peer Reviewed verified by ORBi

Bettendorff, L., & Wins, P. (May 2013). Biological functions of thiamine derivatives: Focus on non-coenzyme roles. OA Biochemistry, 1 (1), 10.
Peer Reviewed verified by ORBi

Bunik, Parkhomenko, Y., Kaehne, T., Mkrtchyan, G., Vovk, A., & Bettendorff, L. (March 2013). Thiamine and thiazolium binding proteome includes DJ-1, amyloid beta and several membrane proteins [Poster presentation]. AD/PD 2013 - The 11th International Conference on Alzheimer's & Parkinson's Diseases, Florence, Italy.

Bettendorff, L., & Wins, P. (2013). Biochemistry of thiamine and thiamine phosphate compounds. In W. J. Lennarz & M. D. Lane (Eds.), The Encyclopedia of Biological Chemistry, vol 1 (2nd edition, pp. 202-209). Waltham, United States - Massachusetts: Academic Press.
Peer reviewed

Bettendorff, L., & Wins, P. (2013). Thiamine triphosphatase and the CYTH family of proteins. FEBS Journal, 280 (24), 6443–6455.
Peer Reviewed verified by ORBi

Graf, A., Trofimova, L., Loshinskaja, A., Mkrtchyan, G., Strokina, A., Lovat, M., Tylicki, A., Strumilo, S., Bettendorff, L., & Bunik, V. I. (2013). Up-regulation of 2-oxoglutarate dehydrogenase as a stress response. International Journal of Biochemistry and Cell Biology, 45, 175-189. doi:10.1016/j.biocel.2012.07.002
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Delvaux, D., Kerff, F., Murty, M. R. V. S., Lakaye, B., Czerniecki, J., Kohn, G., Wins, P., Herman, R., Gabelica, V., Heuze, F., Tordoir, X., Marée, R., Matagne, A., Charlier, P., De Pauw, E., & Bettendorff, L. (2013). Structural Determinants of Specificity and Catalytic Mechanism in mammalian 25-kDa Thiamine Triphosphatase. Biochimica et Biophysica Acta - General Subjects, 1830, 4513-4523. doi:10.1016/j.bbagen.2013.05.014
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Gigliobianco, T., GANGOLF, M., Lakaye, B., Pirson, B., von Ballmoos, C., Wins, P., & Bettendorff, L. (January 2013). An alternative role of FoF1-ATP synthase in Escherichia coli: synthesis of thiamine triphosphate. Scientific Reports, 3 (1071). doi:10.1038/srep01071
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Kohn, G., Delvaux, D., Lakaye, B., Servais, A.-C., Scholer, G., Fillet, M., Elias, B., Derochette, J.-M., Crommen, J., Wins, P., & Bettendorff, L. (12 September 2012). High inorganic triphosphatase activities in bacteria and mammalian cells: Identification of the enzymes involved. PLoS ONE, 7 (9), 43879. doi:10.1371/journal.pone.0043879
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Theatre, E., Frederix, K., Guilmain, W., Delierneux, C., Lecut, C., Bettendorff, L., BOURS, V., & Oury, C. (August 2012). Overexpression of CD39 in mouse airways promotes bacteria induced inflammation. Journal of Immunology, 189 (4), 1966-1974. doi:10.4049/jimmunol.1102600
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Vignisse, J., Steinbusch, H. W. M., Griegoriev, V., Bettendorff, L., Bolkunov, A., Nunes, J., Bachurin, S., & Strekalova, T. (17 July 2012). Simultaneous versus solitary pharmacological manipulation of NMDA- and AMPA- receptors: effects of new drugs on contextual learning and its extinction [Paper presentation]. 8th FENS Forum of Neuroscience, Barcelona, Spain.

Bettendorff, L. (2012). Chapter 17: Thiamin. In J. W. Erdman, Jr, I. A. MacDonald, ... S. H. Zeisel (Eds.), Present Knowledge in Nutrition (10th Edition, pp. 261-279). Blackwell Publishing Ltd.
Peer reviewed

Trofimova, L. K., Araùjo, W. L., Strokina, A. A., Fernie, A. R., Bettendorff, L., & Bunik, V. I. (2012). Consequences of the α-Ketoglutarate Dehydrogenase Inhibition for Neuronal Metabolism and Survival: Implications for Neurodegenerative Diseases. Current Medicinal Chemistry, 19, 5895-5906. doi:10.2174/092986712804143367
Peer Reviewed verified by ORBi

Bettendorff, L. (2012). Chapter 17: Thiamin (E-book). In J. W. Erdman, Jr, I. A. MacDonald, ... S. H. Zeisel (Eds.), Present Knowledge in Nutrition (E-book) (10th Edition, pp. 435-465). Wiley-Blackwell.
Peer reviewed

Bettendorff, L., Delvaux, D., Kohn, G., Wins, P., & Lakaye, B. (2012). Molecular evolution of the CYTH superfamily of proteins [Poster presentation]. 22nd IUBMB & 37th FEBS Congress, Seville, Spain, September 4-9, 2012, Sevilla, Spain.

Hills, J. I., Golub, M. S., Bettendorff, L., & Keen, C. L. (2012). The effect of thiamin tetrahydrofurfuryl disulfide on behavior of juvenile DBA/2J mice. Neurotoxicology and Teratology, 34, 242-252. doi:10.1016/j.ntt.2011.07.006
Peer Reviewed verified by ORBi

Bettendorff, L. (2012). Thiamine : a link with Alzheimer’s disease ? [Paper presentation]. invited conference at the School for Mental Health and Neuroscience, University of Maastricht, Maastricht, Netherlands.

Bettendorff, L. (2012). Chapter 5: The chemistry, biochemistry and metabolism of thiamin (vitamin B1). In V. R. Preedy (Ed.), B Vitamins and Folate: Chemistry, Analysis, Function and Effects (pp. 71-92). Cambridge, United Kingdom: RSC Publishing. doi:10.1039/ 9781849733694
Peer reviewed

Binet, A., Delvaux, D., & Bettendorff, L. (2011). Une invitée surprise.

Vignisse, J., Liégeois, J.-F., Wins, P., & Bettendorff, L. (July 2011). Thiamin derivatives in the brain of a mouse model of Alzheimer's disease and in cultured Neuroblastoma cells treated with benfotiamine [Poster presentation]. FENS/IBRO Summer School 2011: Metabolic Aspects of Chronic Brain Diseases, Gunzburg, Germany.

Delvaux, D., Murty, M. R. V. S., Gabelica, V., Lakaye, B., Lunin, V. V., Skarina, T., Onopriyenko, O., Kohn, G., Wins, P., De Pauw, E., & Bettendorff, L. (2011). A specific inorganic triphosphatase from Nitrosomonas europaea: structure and catalytic mechanism. Journal of Biological Chemistry, 286, 34023-34035. doi:10.1074/jbc.M111.233585
Peer Reviewed verified by ORBi

Bettendorff, L. (2011). Dérivés triphosphorylés inhabituels à l’interface entre le métabolisme des nucléotides et le métabolisme énergétique des cellules [Paper presentation]. Invited conference at the Institut de Génétique et Microbiologie, Université Paris-Sud XI, Orsay, France.

Bettendorff, L. (2011). Unusual thiamine derivatives : Clues to non-cofactor roles of thiamine in prokaryote and eukaryote cell function [Paper presentation]. Invited conference at the Institut des Sciences de la Vie (ISV), Université Catholique de Louvain, Louvain-la-Neuve, Belgium.

Gangolf, M., Czerniecki, J., Radermecker, M., Detry, O., NISOLLE, M., JOUAN, C., Martin, D., Chantraine, F., Lakaye, B., Wins, P., Grisar, T., & Bettendorff, L. (October 2010). Thiamine Status in Humans and Content of Phosphorylated Thiamine Derivatives in Biopsies and Cultured Cells. PLoS ONE, 5 (10), 13616. doi:10.1371/journal.pone.0013616
Peer Reviewed verified by ORBi

Gigliobianco, T., Lakaye, B., Wins, P., Elmoualij, B., Zorzi, W., & Bettendorff, L. (May 2010). Adenosine thiamine triphosphate accumulates in Escherichia coli cells in response to specific conditions of metabolic stress. BMC Microbiology, 10, 148. doi:10.1186/1471-2180-10-148
Peer Reviewed verified by ORBi

Gangolf, M., Wins, P., Thiry, M., Elmoualij, B., & Bettendorff, L. (2010). Thiamine triphosphate synthesis in rat brain occurs in mitochondria and is coupled to the respiratory chain. Journal of Biological Chemistry, 285, 583-594. doi:10.1074/jbc.M109.054379
Peer Reviewed verified by ORBi

Bettendorff, L. (2010). Synthesis of thiamine triphosphate in brain mitochondria and E. coli: possible role of FoF1-ATPase [Paper presentation]. Invited conference at the MRC Mitochondrial Biology Unit (Director John Walker, Prix Nobel de Chimie 1997), Cambridge, United Kingdom.

Bettendorff, L. (2009). Thiamine triphosphate and adenosine thiamine triphosphate: metabolism and physiological significance [Paper presentation]. The 2nd International Workshop-Cum-Training Course on Molecular Medicine and Drug Research, Karachi, Pakistan.

Frederich, M., Delvaux, D., Gigliobianco, T., GANGOLF, M., Dive, G., Mazzucchelli, G., Elias, B., De Pauw, E., Angenot, L., Wins, P., & Bettendorff, L. (2009). Thiaminylated adenine nucleotides — chemical synthesis, structural characterization and natural occurrence. FEBS Journal, 276 (12), 3256–3268. doi:10.1111/j.1742-4658.2009.07040.x
Peer Reviewed verified by ORBi

Bettendorff, L., & Wins, P. (2009). Thiamin diphosphate in biological chemistry: new aspects of thiamin metabolism, especially triphosphate derivatives acting other than as cofactors. FEBS Journal, 276 (11), 2917-2925. doi:10.1111/j.1742-4658.2009.07019.x
Peer Reviewed verified by ORBi

Bettendorff, L. (2008). A tale of two molecules : on the physiological significance of thiamine triphosphate and adenosine thiamine triphosphate [Paper presentation]. The 7th International Conference on Mechansims and Physiology of Thiamine, Wittenberg, Germany.

Bettendorff, L. (2008). Thiamine phosphate derivatives at the interface of cell bioenergetics and nucleotide metabolism: potential implications in aging and neurodegeneration [Paper presentation]. Invited conference at the CNCM Meeting : Towards the discovery of Basic Mechanisms of Neurological Diseases, Liège, Belgium.

Gigliobianco, T., Lakaye, B., Makarchikov, A. F., Wins, P., & Bettendorff, L. (2008). Adenylate Kinase-Independent Thiamine Triphosphate Accumulation under Severe Energy Stress in Escherichia Coli. BMC Microbiology, 8, 16. doi:10.1186/1471-2180-8-16
Peer Reviewed verified by ORBi

Song, J., Bettendorff, L., Tonelli, M., & Markley, J. L. (2008). Structural basis for the catalytic mechanism of mammalian 25 kDa thiamine triphosphatase. Journal of Biological Chemistry, 283, 10939-10948. doi:10.1074/jbc.M709675200
Peer Reviewed verified by ORBi

Volvert, M.-L., Seyen, S., Piette, M., Evrard, B., Gangolf, M., Plumier, J.-C., & Bettendorff, L. (2008). Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. BMC Pharmacology, 8, 10. doi:10.1186/1471-2210-8-10
Peer Reviewed verified by ORBi

Theatre, E., de Leval, L., Bettendorff, L., Bours, V., & Oury, C. (2008). Overexpression of airway CD39 in transgenic mice enhances lipopolysaccharide-induced inflammation. Purinergic Signalling, 4, 113.
Peer reviewed

Gangolf, M., Wins, P., Thiry, M., & Bettendorff, L. (2008). Evidence for a mitochondrial synthesis of thiamine triphosphate in the rat brain [Paper presentation]. 7th International Conference on mechanisms and physiology of thiamine, Lutherstadt Wittenburg, Germany.

Bettendorff, L. (2007). At the crossroad of thiamine degradation and biosynthesis. Nature Chemical Biology, 3 (8), 454-455. doi:10.1038/nchembio0807-454

Bettendorff, L. (2007). New evidence for a non-cofactor role of thiamine phosphate derivatives [Paper presentation]. Invited conference at the Katholieke Universiteit Leuven, Department of molecular Cell Biology, Leuven, Belgium.

Makarchikov, A. F., Brans, A., & Bettendorff, L. (2007). Thiamine Diphosphate Adenylyl Transferase from E. Coli: Functional Characterization of the Enzyme Synthesizing Adenosine Thiamine Triphosphate. BMC Biochemistry, 8, 17. doi:10.1186/1471-2091-8-17
Peer Reviewed verified by ORBi

Bettendorff, L. (2007). Thiamine triphosphate and adenosine thiamine triphosphate: New signals in bacterial stress response ? [Paper presentation]. Minisymposium: Biosynthesis of Vitamine, Brussels, Belgium.

Bettendorff, L., Wirtzfeld, B., Makarchikov, A. F., Mazzucchelli, G., Frederich, M., Gigliobianco, T., Gangolf, M., De Pauw, E., Angenot, L., & Wins, P. (2007). Discovery of a natural thiamine adenine nucleotide. Nature Chemical Biology, 3 (4), 211-212. doi:10.1038/nchembio867
Peer Reviewed verified by ORBi

Szyniarowski, P., Bettendorff, L., & Schweingruber, M. E. (2006). The antitrypanosomal drug melarsoprol competitively inhibits thiamin uptake in mouse neuroblastoma cells. Cell Biology and Toxicology, 22 (3), 183-187. doi:10.1007/s10565-006-0034-z
Peer Reviewed verified by ORBi

Makarchikov, A. F., & Bettendorff, L. (2005). Distrribution of specific thiamine triphosphatase in biological objects. News of Biomedical Sciences, 2, 55-60.
Peer reviewed

Szyniarowski, P., Lakaye, B., Czerniecki, J., Makarchikov, A. F., Wins, P., Margineanu, I., Coumans, B., Grisar, T., & Bettendorff, L. (2005). Pig tissues express a catalytically inefficient 25-kDa thiamine triphosphatase: Insight in the catalytic mechanisms of this enzyme. Biochimica et Biophysica Acta - General Subjects, 1725 (1), 93-102. doi:10.1016/j.bbagen.2005.05.026
Peer Reviewed verified by ORBi

Lakaye, B., Verlaet, M., Dubail, J., Czerniecki, J., Bontems, S., Makarchikov, A. F., Wins, P., Piette, J., Grisar, T., & Bettendorff, L. (2004). Expression of 25 kDa thiamine triphosphatase in rodent tissues using quantitative PCR and characterization of its mRNA. International Journal of Biochemistry and Cell Biology, 36 (10), 2032-2041. doi:10.1016/j.biocel.2004.03.004
Peer Reviewed verified by ORBi

Lakaye, B., Wirtzfeld, B., Wins, P., Grisar, T., & Bettendorff, L. (2004). Thiamine triphosphate, a new signal required for optimal growth of Escherichia coli during amino acid starvation. Journal of Biological Chemistry, 279 (17), 17142-17147. doi:10.1074/jbc.M313569200
Peer Reviewed verified by ORBi

Bettendorff, L. (2004). Le triphosphate de thiamine : une nouvelle molécule de signalisation ? [Paper presentation]. Invited Conference at the University of Luxembourg, Campus Limpertsberg, Luxembourg, Luxembourg.

Czerniecki, J., Chanas, G., Verlaet, M., Bettendorff, L., Makarchikov, A. F., Leprince, P., Wins, P., Grisar, T., & Lakaye, B. (2004). Neuronal localization of the 25-kDa specific thiamine triphosphatase in rodent brain. Neuroscience, 125 (4), 833-840. doi:10.1016/j.neuroscience.2004.02.033
Peer Reviewed verified by ORBi

Makarchikov, A. F., & Bettendorff, L. (2004). A study of the quantitative content of thiamine triphosphate in different biological objects by high-performance liquid chromatography. News of Biomedical Sciences, 2, 70-76.
Peer reviewed

Bettendorff, L., & Wins, P. (2004). New perspectives on the cellular role of thiamine triphosphate and thiamine triphosphatase. In M. S. Patel & F. Jordan (Eds.), Thiamine: catalytic mechanisms and role in normal and disease states (pp. 43-56). New York, United States: Maecel Dekker.

Bettendorff, L. (2004). Thiamine triphosphate from bacteria to mammals : a new molecule involved in stress response [Paper presentation]. Invited conference at the Forschungszentrum Juelich (Allemagne), Institut für Biotechnologie und Institut für Molekulare Enzymtechnologie, Juelich, Germany.

Lakaye, B., Makarchikov, A. F., Wins, P., Margineanu, I., Roland, S., Lins, L., Aichour, R., Lebeau, L., Elmoualij, B., Zorzi, W., Coumans, B., Grisar, T., & Bettendorff, L. (2004). Human recombinant thiamine triphosphatase: purification, secondary structure and catalytic properties. International Journal of Biochemistry and Cell Biology, 36 (7), 1348-1364. doi:10.1016/j.biocel.2003.11.013
Peer Reviewed verified by ORBi

Bettendorff, L., Nghiem, H. O., Wins, P., & Lakaye, B. (2003). A general method for the chemical synthesis of gamma-P-32-labeled or unlabeled nucleoside 5 '-triphosphates and thiamine triphosphate. Analytical Biochemistry, 322 (2), 190-197. doi:10.1016/j.ab.2003.08.013
Peer Reviewed verified by ORBi

Wins, P., Margineanu, I., Penelle, J., Angenot, L., Grisar, T., & Bettendorff, L. (2003). Bisindole alkaloids from Strychnos guianensis are effective antagonists of nicotinic acetylcholine receptors in cultured human TE671 cells. Naunyn-Schmiedeberg's Archives of Pharmacology, 367 (3), 253-259. doi:10.1007/s00210-003-0692-9
Peer Reviewed verified by ORBi

Nguyen, L., Malgrange, B., Breuskin, I., Bettendorff, L., Moonen, G., Belachew, S., & Rigo, J.-M. (2003). Autocrine/paracrine activation of the GABA(A) receptor inhibits the proliferation of neurogenic polysialylated neural cell adhesion molecule-positive (PSA-NCAM+) precursor cells from postnatal striatum. Journal of Neuroscience, 23 (8), 3278-94. doi:10.1523/jneurosci.23-08-03278.2003
Peer Reviewed verified by ORBi

Makarchikov, A. F., Lakaye, B., Gulyai, I. E., Czerniecki, J., Coumans, B., Wins, P., Grisar, T., & Bettendorff, L. (2003). Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals. Cellular and Molecular Life Sciences, 60 (7), 1477-1488. doi:10.1007/s00018-003-3098-4
Peer Reviewed verified by ORBi

Ruelle, V., Zorzi, W., Elmoualij, B., Pierard, O., Heinen, E., Lakaye, B., Bettendorff, L., Rees, J., Voorhees, K., & De Pauw, E. (2003). Fingerprint matching of genetically modified E.coli strains by MALDI-TOF Mass Spectrometry of whole cells using a k-nearest-neighbors approach [Poster presentation]. 8th Conference on Food Microbiology. 19-20 Juin 2003. Liège – Belgique.

Bettendorff, L., Lakaye, B., Margineanu, I., Grisar, T., & Wins, P. (2002). ATP-driven, Na(+)-independent inward Cl- pumping in neuroblastoma cells. Journal of Neurochemistry, 81 (4), 792-801. doi:10.1046/j.1471-4159.2002.00858.x
Peer Reviewed verified by ORBi

Lakaye, B., Makarchikov, A. F., Antunes, A. F., Zorzi, W., Coumans, B., De Pauw, E., Wins, P., Grisar, T., & Bettendorff, L. (2002). Molecular characterization of a specific thiamine triphosphatase widely expressed in mammalian tissues. Journal of Biological Chemistry, 277 (16), 13771-13777. doi:10.1074/jbc.M111241200
Peer Reviewed verified by ORBi

Bettendorff, L. (2002). Relevance of molecular biology to Psychopharmacology [Paper presentation]. Euron courses 2002, Workshop on Psychoimmunology, Psychoendodrinology & Psychopharmacology, Kerkgrade, Netherlands.

Makarchikov, A. F., Luchko, A. A., Bettendorff, L., Lakaye, B., & Wins, P. (2002). Study of the role of ionogenic amino-acid residues in catalytic activity of thiamine triphosphatase from bovine kidney by means of chemical modification. News of Biomedical Sciences, 3, 66-70.
Peer reviewed

Bettendorff, L. (2002). New perspectives on the cellular role of thiamine triphosphate and thiamine triphosphatase [Paper presentation]. International Conference on Thiamin, its Biochemistry and structural Biology, Newark, United States.

Makarchikov, A. F., Wins, P., Janssen, E., Wieringa, B., Grisar, T., & Bettendorff, L. (2002). Adenylate kinase 1 knockout mice have normal thiamine triphosphate levels. BBA Molecular Cell Research, 1592 (2), 117-121. doi:10.1016/S0167-4889(02)00277-X
Peer Reviewed verified by ORBi

Nghiêm, H. O., Bettendorff, L., & Changeux, J.-P. (2000). Specific phosphorylation of Torpedo 43 rapsyn by endogenous kinase(s) with thiamine triphosphate as the phosphate donor. FASEB Journal, 14, 543-554. doi:10.1096/fasebj.14.3.543
Peer Reviewed verified by ORBi

Bettendorff, L., & Wins, P. (1999). Thiamine derivatives in excitable tissues: Metabolism, deficiency and neurodegenerative diseases. In S. G. Pandalai (Ed.), Recent Research Developments in Neurochemistry, vol 2, part 1 (pp. 37-62). Trivandrum, India: Research Signpost.

Grisar, T., Lakaye, B., Thomas, E., Bettendorff, L., & Minet, A. (1999). The Molecular Neuron-Glia Couple and Epileptogenesis. Advances in Neurology, 79, 591-602.
Peer Reviewed verified by ORBi

Bettendorff, L. (1999). Thiamine triphosphate, a new modulator of protein activity [Paper presentation]. 1st EURON symposium "Neuroscience at eight Euregio Universities", Maastricht, Netherlands.

Grisar, T., Lakaye, B., Thomas, E., Bettendorff, L., & Minet, A. (1999). The molecular neuron-glia couple and epileptogenesis. In A. V. Delgado-Escueta, W. A. Wilson, R. W. Olsen, ... R. J. Porter (Eds.), Jasper's Basic Mechanisms of the Epilepsies, 3rd edition. Philadelphia, United States - Pennsylvania: Lippincott Williams & Wilkins.

Bettendorff, L., Mastrogiacomo, F., Wins, P., Kish, S. J., Grisar, T., & Ball, M. J. (1997). Low Thiamine Diphosphate Levels in Brains of Patients with Frontal Lobe Degeneration of the Non-Alzheimer's Type. Journal of Neurochemistry, 69 (5), 2005-2010. doi:10.1046/j.1471-4159.1997.69052005.x
Peer Reviewed verified by ORBi

Bettendorff, L., Goessens, G., & Sluse, F. (1997). Reversibility of thiamine deficiency-induced partial necrosis and mitochondrial uncoupling by addition of thiamine to neuroblastoma cell suspensions. Molecular and Cellular Biochemistry, 174 (1-2), 121-4. doi:10.1023/A:1006842609998
Peer Reviewed verified by ORBi

Bettendorff, L. (1997). Low thiamine status in human brain: a post-mortem study in control and demented patients [Paper presentation]. Joint Meeting of the International Society for Neurochemistry and the American Society for Neurochemistry, Boston, United States.

Bettendorff, L., Mastrogiacomo, F., Kish, S. J., & Grisar, T. (1996). Thiamine, Thiamine Phosphates, and Their Metabolizing Enzymes in Human Brain. Journal of Neurochemistry, 66 (1), 250-8. doi:10.1046/j.1471-4159.1996.66010250.x
Peer Reviewed verified by ORBi

Bettendorff, L., Sallanon-Moulin, M., Touret, M., Wins, P., Margineanu, I., & Schoffeniels, E. (1996). Paradoxical Sleep Deprivation Increases the Content of Glutamate and Glutamine in Rat Cerebral Cortex. Sleep, 19 (1), 65-71. doi:10.1093/sleep/19.1.65
Peer Reviewed verified by ORBi

Mastrogiacomo, F., LaMarche, J., Dozic, S., Lindsay, G., Bettendorff, L., Robitaille, Y., Schut, L., & Kish, S. J. (1996). Immunoreactive levels of α-ketoglutarate dehydrogenase subunits in Friedreich's ataxia and spinocerebellar ataxia type 1. Neurodegeneration: A Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration, 5, 27-33. doi:10.1006/neur.1996.0004
Peer Reviewed verified by ORBi

Mastrogiacomo, F., Lindsay, J. G., Bettendorff, L., Rice, J., & Kish, S. J. (1996). Brain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. Annals of Neurology, 39, 592-598. doi:10.1002/ana.410390508
Peer Reviewed verified by ORBi

Mastrogiacomo, F., Bettendorff, L., Grisar, T., & Kish, S. J. (1996). Brain thiamine, its phosphate esters, and its metabolizing enzymes in Alzheimer's disease. Annals of Neurology, 39, 585-591. doi:10.1002/ana.410390507
Peer Reviewed verified by ORBi

Bettendorff, L., Mastrogiacomo, F., LaMarche, J., Dozic, S., & Kish, S. J. (1996). Brain Levels of Thiamine and Its Phosphate Esters in Friedreich's Ataxia and Spinocerebellar Ataxia Type 1. Movement Disorders, 11 (4), 437-439. doi:10.1002/mds.870110415
Peer Reviewed verified by ORBi

Bettendorff, L. (1996). A Non-Cofactor Role of Thiamine Derivatives in Excitable Cells? Archives of Physiology and Biochemistry, 104 (6), 745-751. doi:10.1076/apab.104.6.745.12916
Peer Reviewed verified by ORBi

Bettendorff, L., Sluse, F., Goessens, G., Wins, P., & Grisar, T. (1995). Thiamine Deficiency--Induced Partial Necrosis and Mitochondrial Uncoupling in Neuroblastoma Cells Are Rapidly Reversed by Addition of Thiamine. Journal of Neurochemistry, 65 (5), 2178-2184. doi:10.1046/j.1471-4159.1995.65052178.x
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Bettendorff, L. (1995). Thiamine Homeostasis in Neuroblastoma Cells. Neurochemistry International, 26 (3), 295-302. doi:10.1016/0197-0186(94)00123-C
Peer Reviewed verified by ORBi

Bettendorff, L. (1995). A non-cofactor role of thiamine and its derivatives in excitable cells [Paper presentation]. International Symposium: The Land of Bioelectrogenesis Revisited, Liege, Belgium.

Bettendorff, L., Margineanu, I., Wins, P., & Grisar, T. (1995). An Atypical Anion Transporter Functioning at Acid pH in Neuroblastoma Cells. Biochemical and Biophysical Research Communications, 207 (1), 375-381. doi:10.1006/bbrc.1995.1198
Peer reviewed

Bettendorff, L. (1995). La thiamine et ses dérivés dans le métabolisme, l'excitabilité et les processus abiotrophiques des cellules nerveuses [Post doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/126931

Bettendorff, L., Goessens, G., Sluse, F., Wins, P., Bureau, M., Laschet, J., & Grisar, T. (1995). Thiamine Deficiency in Cultured Neuroblastoma Cells: Effect on Mitochondrial Function and Peripheral Benzodiazepine Receptors. Journal of Neurochemistry, 64 (5), 2013-2021. doi:10.1046/j.1471-4159.1995.64052013.x
Peer Reviewed verified by ORBi

Bettendorff, L. (1994). Thiamine in Excitable Tissues: Reflections on a Non-Cofactor Role. Metabolic Brain Disease, 9 (3), 183-209. doi:10.1007/BF01991194
Peer Reviewed verified by ORBi

Bettendorff, L., Wins, P., & Lesourd, M. (1994). Subcellular Localization and Compartmentation of Thiamine Derivatives in Rat Brain. Biochimica et Biophysica Acta, 1222 (1), 1-6. doi:10.1016/0167-4889(94)90018-3
Peer Reviewed verified by ORBi

Bettendorff, L. (1994). Transport and metabolism of thiamine [Paper presentation]. Invited Conference et the Laboratory of Microbiology (Prof. M.E. Schweingruber), Bern, Switzerland.

Bettendorff, L., Hennuy, B., De Clerck, A., & Wins, P. (1994). Chloride Permeability of Rat Brain Membrane Vesicles Correlates with Thiamine Triphosphate Content. Brain Research, 652 (1), 157-160. doi:10.1016/0006-8993(94)90331-X
Peer Reviewed verified by ORBi

Bettendorff, L. (1994). The Compartmentation of Phosphorylated Thiamine Derivatives in Cultured Neuroblastoma Cells. Biochimica et Biophysica Acta, 1222 (1), 7-14. doi:10.1016/0167-4889(94)90019-1
Peer Reviewed verified by ORBi

Bettendorff, L., & Wins, P. (1994). Mechanism of Thiamine Transport in Neuroblastoma Cells. Inhibition of a High Affinity Carrier by Sodium Channel Activators and Dependence of Thiamine Uptake on Membrane Potential and Intracellular Atp. Journal of Biological Chemistry, 269 (20), 14379-14385.
Peer Reviewed verified by ORBi

Bettendorff, L., Peeters, M., Wins, P., & Schoffeniels, E. (1993). Metabolism of Thiamine Triphosphate in Rat Brain: Correlation with Chloride Permeability. Journal of Neurochemistry, 60 (2), 423-434. doi:10.1111/j.1471-4159.1993.tb03168.x
Peer Reviewed verified by ORBi

Bettendorff, L., Kolb, H.-A., & Schoffeniels, E. (1993). Thiamine Triphosphate Activates an Anion Channel of Large Unit Conductance in Neuroblastoma Cells. Journal of Membrane Biology, 136 (3), 281-8. doi:10.1007/BF00233667
Peer Reviewed verified by ORBi

Bettendorff, L., Hennuy, B., Wins, P., & Schoffeniels, E. (1993). Thiamin and Derivatives as Modulators of Rat Brain Chloride Channels. Neuroscience, 52 (4), 1009-1017. doi:10.1016/0306-4522(93)90547-S
Peer Reviewed verified by ORBi

Bettendorff, L., Peeters, M., Jouan, C., Wins, P., & Schoffeniels, E. (1991). Determination of Thiamin and Its Phosphate Esters in Cultured Neurons and Astrocytes Using an Ion-Pair Reversed-Phase High-Performance Liquid Chromatographic Method. Analytical Biochemistry, 198 (1), 52-59. doi:10.1016/0003-2697(91)90505-N
Peer Reviewed verified by ORBi

Bettendorff, L., Longree, I., Wins, P., & Schoffeniels, E. (1991). Solubilization of Thiamine Triphosphatase from the Electric Organ of Electrophorus Electricus. Biochimica et Biophysica Acta - General Subjects, 1073 (1), 69-76. doi:10.1016/0304-4165(91)90184-I
Peer Reviewed verified by ORBi

Bettendorff, L. (1991). Application of High-Performance Liquid Chromatography to the Study of Thiamine Metabolism and in Particular Thiamine Triphosphatase. Journal of Chromatography. A, 566 (2), 397-408. doi:10.1016/0378-4347(91)80256-C
Peer Reviewed verified by ORBi

Bettendorff, L., Weekers, L., Wins, P., & Schoffeniels, E. (1990). Injection of Sulbutiamine Induces an Increase in Thiamine Triphosphate in Rat Tissues. Biochemical Pharmacology, 40 (11), 2557-2560. doi:10.1016/0006-2952(90)90099-7
Peer Reviewed verified by ORBi

Bettendorff, L., Wins, P., & Schoffeniels, E. (1990). Regulation of Ion Uptake in Membrane Vesicles from Rat Brain by Thiamine Compounds. Biochemical and Biophysical Research Communications, 171 (3), 1137-1144. doi:10.1016/0006-291X(90)90803-U
Peer reviewed

Bettendorff, L. (1990). Application of high-performance liquid chromatography to the study of thiamine metabolism and in particular thiamine triphosphatase [Paper presentation]. First International Symposium on Applications of HPLC in Enzyme Chemistry, Verona, Italy.

Bettendorff, L., Grandfils, C., Wins, P., & Schoffeniels, E. (1989). Thiamine Triphosphatase in the Membranes of the Main Electric Organ of Electrophorus Electricus: Substrate-Enzyme Interactions. Journal of Neurochemistry, 53 (3), 738-746. doi:10.1111/j.1471-4159.1989.tb11767.x
Peer Reviewed verified by ORBi

De Rycker, C., Grandfils, C., Bettendorff, L., & Schoffeniels, E. (1989). Solubilization of Sodium Channel from Human Brain. Journal of Neurochemistry, 52 (2), 349-53. doi:10.1111/j.1471-4159.1989.tb09128.x
Peer Reviewed verified by ORBi

Bettendorff, L., Schoffeniels, E., Naquet, R., Silva-Barrat, C., Riche, D., & Menini, C. (1989). Phosphorylated Thiamine Derivatives and Cortical Activity in the Baboon Papio Papio: Effect of Intermittent Light Stimulation. Journal of Neurochemistry, 53 (1), 80-87. doi:10.1111/j.1471-4159.1989.tb07297.x
Peer Reviewed verified by ORBi

Bettendorff, L. (1988). Triphosphate de thiamine et bioélectrogenèse [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/126930

Grandfils, C., Bettendorff, L., de Rycker, C., & Schoffeniels, E. (1988). Synthesis of [Gamma-32p]Thiamine Triphosphate. Analytical Biochemistry, 169 (2), 274-278. doi:10.1016/0003-2697(88)90285-0
Peer Reviewed verified by ORBi

Bettendorff, L., Wins, P., & Schoffeniels, E. (1988). Thiamine Triphosphatase from Electrophorus Electric Organ Is Anion-Dependent and Irreversibly Inhibited by 4,4'-Diisothiocyanostilbene-2,2'disulfonic Acid. Biochemical and Biophysical Research Communications, 154 (3), 942-947. doi:10.1016/0006-291X(88)90230-6
Peer reviewed

Bettendorff, L., Michel-Cahay, C., Grandfils, C., De Rycker, C., & Schoffeniels, E. (1987). Thiamine triphosphate and membrane-associated thiamine phosphatases in the electric organ of Electrophorus electricus. Journal of Neurochemistry, 49, 495-502. doi:10.1111/j.1471-4159.1987.tb02891.x
Peer Reviewed verified by ORBi

Bettendorff, L., & Schoffeniels, E. (1987). Activités thiamine triphophatasiques et bioélectrogenèse. Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique, 142 (2-3), 228-236.
Peer Reviewed verified by ORBi

Bettendorff, L., Grandfils, C., De Rycker, C., & Schoffeniels, E. (1986). Determination of thiamine and its phosphate esters in human blood serum at femtomole levels. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 382, 297-302.
Peer Reviewed verified by ORBi

Michel-Cahay, C., Bettendorff, L., De Rycker, C., Grandfils, C., & Schoffeniels, E. (03 September 1985). Membrane associated thiamine phosphatases in the electric organ of Electrophorus electricus [Poster presentation]. XII Forum des Jeunes Chercheurs, Liège, Liège, Belgium.

Grandfils, C., Cesa, D., Bettendorff, L., & De Rycker, C. (03 September 1985). Synthèse de triphosphate de thiamine avec incorporation de phosphore 32 en position gamma [Poster presentation]. XII Forum des Jeunes Chercheurs, Liège, Liège, Belgium.

Dandrifosse, G., Grandfils, C., Bettendorff, L., Schoffeniels, E., & Bontemps, J. (1985). Rapid purification procedure of the Na-channel of Electrophorus electricus. In J.-P. Changeux, A. Maelicke, ... E. Neumann (Eds.), Molecular Basis of Nerve Activity (pp. 163-172). Berlin, Germany: Walter de Gruyter & Co.

Michel-Cahay, C., Bettendorff, L., De Rycker, C., Grandfils, C., & Schoffeniels, E. (1985). Membrane associated thiamin phosphatases in the electric organ of E. electricus. Archives Internationales de Physiologie et de Biochimie, 93, 20.
Peer Reviewed verified by ORBi

Dandrifosse, G., Grandfils, C., Bettendorff, L., Schoffeniels, E., & Bontemps, J. (1985). A purification procedure of the tetrodotoxin binding component contained in the electroplaxes of E. electricus. In J. P. Changeux, A. Maelicke, ... E. Neumann (Eds.), Molecular Basis of Nerve Activity (pp. 163-175). Walter de Gruyter et Co.
Peer reviewed

Grandfils, C., Bettendorff, L., Schoffeniels, E., Bontemps, J., & Dandrifosse, G. (1985). High yield synthesis of a new Na-channel marker, [3H]-ethylenediamine ditetrodotoxin, EDD-TTX. In J.-P. Changeux, A. Maelicke, ... E. Neumann (Eds.), Molecular Basis of Nerve Activity (pp. 153-162). Berlin, Germany: Walter de Gruyter & Co.

Bettendorff, L., Schoffeniels, E., Schmartz, D., Bontemps, J., Dandrifosse, G., & Grandfils, C. (Other coll.). (1985). Determination of thiamine and its phosphate esters by reversed-phase HPLC at femtomole levels. Application to bioelectrogenesis. In J.-P. Changeux, A. Maelicke, ... E. Neumann (Eds.), Molecular Basis of Nerve Activity (pp. 479-490). Berlin, Germany: Walter de Gruyter & Co.

Bontemps, J., Grandfils, C., Bettendorff, L., Dandrifosse, G., & Schoffeniels, E. (1985). High performance gel filtration as a tool for the monitoring of the purification steps of the Na channel protein. Archives Internationales de Physiologie et de Biochimie, 93, 5-B6.
Peer Reviewed verified by ORBi

Grandfils, C., Bettendorff, L., Schoffeniels, E., Bontemps, J., & Dandrifosse, G. (1985). Dérivés phosphorylés de la thiamine et bioélectrogenèse. Regards sur la biochimie, 4, 65.
Peer reviewed

Bettendorff, L., Grandfils, C., Schoffeniels, E., Bontemps, J., Schmartz, D., & Dandrifosse, G. (October 1984). Determination of thiamine and its phosphate esters by reversed phase HPLC at femtomole levels. Application to bioelectrogenesis [Paper presentation]. International Symposium in Memory of D. Nachmansohon on Molecular Basis of Nerve Activity, Berlin, Germany.

Dandrifosse, G., Grandfils, C., Bettendorff, L., Schoffeniels, E., & Bontemps, J. (1984). A purification procedure of the tetrodotoxin binding component coming from the electroplaxes of E. electricus. In J. P. Changeux, A. Maelicke, ... E. Neumann (Eds.), Molecular Basis of Nerve Activity. Walter de Gruyter et Co.
Peer reviewed

Grandfils, C., Bettendorff, L., Schoffeniels, E., Bontemps, J., & Dandrifosse, G. (September 1984). Dérivés phosphorylés de la thiamine et bioélectrogenèse [Poster presentation]. Forum des jeunes chercheurs, Grenoble (France), Grenoble, France.

Bontemps, J., Laschet, L., Bettendorff, L., Van Cutsem, J. L., Grandfils, C., Etienne, A., Lombet, J., Grisard, T., Dandrifosse, G., Schoffeniels, E., & Forget, P. (18 May 1984). HPLC in neurochemistry [Poster presentation]. Réunion du groupe de Contact chromatographie, FNRS, Liège, Sart Tilman, Liège, Belgium.

Bettendorff, L., Bontemps, J., Lombet, J., Grandfils, C., Compère, P., Dandrifosse, G., & Schoffeniels, E. (25 February 1984). Experimental evidence of the role of thiamine in nerve conduction as determined by HPLC using pre and post column derivatization techniques [Poster presentation]. 125e Réunion de la Société Belge de Biochimie, Rhode-Saint-Genèse.

Bettendorff, L., Bontemps, J., Lombet, J., Grandfils, C., Compère, P., Dandrifosse, G., & Schoffeniels, E. (1984). Experimental evidence of the role of thiamine in nerve conduction as determined by HPLC using pre- and post-column derivatization techniques. Archives Internationales de Physiologie et de Biochimie, 92, 4.
Peer Reviewed verified by ORBi

Bontemps, J., Philippe, P., Bettendorff, L., Lombet, J., Dandrifosse, G., Schoffeniels, E., & Crommen, J. (1984). Determination of thiamine and thiamine phosphates in excitable tissues as thiochrome derivatives by reversed phase high-performance liquid chromatography on octadecyl-silica. Journal of Chromatography. Biomedical Applications, 307, 283-294. doi:10.1016/S0378-4347(00)84100-6
Peer Reviewed verified by ORBi

Schoffeniels, E., Dandrifosse, G., & Bettendorff, L. (1984). Phosphate derivatives of thiamine and Na-channel in conducting membranes. Journal of Neurochemistry, 43, 269-272. doi:10.1111/j.1471-4159.1984.tb06706.x
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Bontemps, J., Bettendorff, L., Lombet, J., Grandfils, C., Dandrifosse, G., Schoffeniels, E., Crommen, J., & Nevejans, M. (1984). Poly(styrene-divinylbenzene) as reversed phase adsorbent for the high-performance liquid chromatographic analysis of thiochrome derivatives of thiamine and phosphorylated esters. Journal of Chromatography. A, 295, 486-491. doi:10.1016/S0021-9673(01)87651-2
Peer Reviewed verified by ORBi

Bontemps, J., Bettendorff, L., Dandrifosse, G., Schoffeniels, E., & Nevejans, F. (1984). Sensitization of thiamine analysis by the peak compression technique. HRC and CC. Journal of High Resolution Chromatography and Chromatography Communications, 7, 490-491. doi:10.1002/jhrc.1240070810
Peer reviewed

Bontemps, J., Bettendorff, L., Lombet, J., Dandrifosse, G., Schoffeniels, E., Nevejans, F., Yang, Y., & Verzele, M. (1984). Determination of thiamine and thiamine phosphates as thiochrome derivatives by reversed phase chromatography on polystyrene packing materials. Chromatographia, 18, 424-426. doi:10.1007/BF02262970
Peer Reviewed verified by ORBi

Bettendorff, L. (1983). Importance de la thiamine et de ses dérivés phosphorés au cours de la bioélectrogenèse [Master’s dissertation, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/126929

Bettendorff, L., Bontemps, J., Dandrifosse, G., & Schoffeniels, E. (1983). Monitoring of thiamine and its phosphate esters during the purification of the tetrodotoxin receptor from Electrophorus electricus membranes. IRCS Medical Science, 11, 1098-1099.
Peer reviewed

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