Article (Scientific journals)
Fine-Mapping of Quantitative Trait Loci by Identity by Descent in Outbred Populations: Application to Milk Production in Dairy Cattle
Riquet, J.; Coppieters, Wouter; Cambisano, Nadine et al.
1999In Proceedings of the National Academy of Sciences of the United States of America, 96 (16), p. 9252-9257
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Abstract :
[en] We previously mapped a quantitative trait locus (QTL) affecting milk production to bovine chromosome 14. To refine the map position of this QTL, we have increased the density of the genetic map of BTA14q11-16 by addition of nine microsatellites and three single nucleotide polymorphisms. Fine-mapping of the QTL was accomplished by a two-tiered approach. In the first phase, we identified seven sires heterozygous "Qq" for the QTL by marker-assisted segregation analysis in a Holstein-Friesian pedigree comprising 1,158 individuals. In a second phase, we genotyped the seven selected sires for the newly developed high-density marker map and searched for a shared haplotype flanking an hypothetical, identical-by-descent QTL allele with large substitution effect. The seven chromosomes increasing milk fat percentage were indeed shown to carry a common chromosome segment with an estimated size of 5 cM predicted to contain the studied QTL. The same haplotype was shown to be associated with increased fat percentage in the general population as well, providing additional support in favor of the location of the QTL within the corresponding interval.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Riquet, J.
Coppieters, Wouter ;  Université de Liège - ULiège > Département de productions animales > Département de productions animales
Cambisano, Nadine ;  Université de Liège - ULiège > Département de productions animales > Génomique animale
Arranz, J. J.
Berzi, P.
Davis, S. K.
Grisart, B.
Farnir, Frédéric  ;  Université de Liège - ULiège > Département de productions animales > Biostatistique, économie, sélection animale
Karim, Latifa ;  Université de Liège - ULiège > Département de productions animales > Génomique animale
Mni, Myriam ;  Université de Liège - ULiège > Département de productions animales > Génomique animale
Simon, P.
Taylor, J. F.
Vanmanshoven, P.
Wagenaar, D.
Womack, J. E.
Georges, Michel  ;  Université de Liège - ULiège > Département de productions animales > Génomique animale
More authors (6 more) Less
Language :
English
Title :
Fine-Mapping of Quantitative Trait Loci by Identity by Descent in Outbred Populations: Application to Milk Production in Dairy Cattle
Publication date :
1999
Journal title :
Proceedings of the National Academy of Sciences of the United States of America
ISSN :
0027-8424
eISSN :
1091-6490
Publisher :
National Academy of Sciences, Washington, United States - District of Columbia
Volume :
96
Issue :
16
Pages :
9252-9257
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
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