Article (Scientific journals)
Commentary: Internal medicine at the crossroads of long COVID diagnosis and management
Spanoghe, Martin; Molmans, Thomas H. J.; Antonacci, Tomaso et al.
2026In Frontiers in Medicine, 13
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Keywords :
biomedical evidence; clinical uncertainty; epistemic humility; long Covid; patient harm; post-acute infection syndromes; psychologization; reflexivity
Abstract :
[en] We read with attention the article by Ranque and Cogan (1) entitled “Internal medicine at the crossroads of Long COVID diagnosis and management.” While the authors raise questions regarding the interplay between persistent symptoms, psychological factors, and illness perception in Long COVID (LC), key aspects of their interpretation do not reflect substantial biomedical evidence, thereby affecting the conclusions drawn. In addition, little attention is paid to the epistemic and clinical implications of uncertainty, including the harm it has caused patients. This commentary offers a constructive critique and proposes a more comprehensive perspective of LC with direct impact on patient care.
Disciplines :
Immunology & infectious disease
Author, co-author :
Spanoghe, Martin;  Long Covid Belgium, Patient Organization ; Laboratoire de biotechnologie et biologie appliquée, Département d'Agrobiosciences et chimie, Haute Ecole Provinciale de Hainaut Condorcet
Molmans, Thomas H. J.;  Post-COVID Network Netherlands ; Stichting Long COVID/Dutch Foundation for Long COVID Research
Antonacci, Tomaso;  Long Covid Belgium, Patient Organization
Burel, Emilie;  Long Covid Belgium, Patient Organization ; Department of Research and Development, AMC Bio
Herschke, Florence;  Long Covid Belgium, Patient Organization ; Department of Research and Development, AMC Bio
Schneider, Nicole ;  Université de Liège - ULiège > CARE "ULiège Library" > ULiège Library : Santé ; Long Covid Belgium, Patient Organization ; Department of Psychology, FernUniversität
Oustric, Pauline;  Association #ApresJ20 Covid Long France, Patient Organization
Thielemans, Paul;  Internal Medicine, Centre Hospitalier EpiCURA
Nicolas, Jean-Baptiste;  Service de Médecine Interne Générale, Onco-Hématologie, Endocrinologie et Rhumatologie, Clinique Saint-Luc Bouge
Dauby, Nicolas;  Department of Infectious Diseases, CHU Saint-Pierre, Université Libre de Bruxelles (ULB) ; School of Public Health, Université Libre de Bruxelles (ULB) ; U-CRI, Université Libre de Bruxelles (ULB)
Nicaise, Charles;  URPhyM, NARILIS, Université de Namur
Van Weyenbergh, Johan;  Laboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research
Jamoulle, Marc  ;  Université de Liège - ULiège > HEC Liège : UER > UER Opérations : Systèmes d'information de gestion
More authors (3 more) Less
Language :
English
Title :
Commentary: Internal medicine at the crossroads of long COVID diagnosis and management
Publication date :
15 April 2026
Journal title :
Frontiers in Medicine
eISSN :
2296-858X
Publisher :
Frontiers Media SA
Volume :
13
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 April 2026

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