Towards interbreed IBD fine mapping of the mh locus: double-muscling in the Asturiana de los Valles breed involves the same locus as in the Belgian Blue cattle breed.

Dunner, S.; Charlier, Carole; Farnir, Frédéric; Brouwers, Benoît; Canon, J.; Georges, Michel

doi:10.1007/s003359900462

Article (Scientific journals)

Towards interbreed IBD fine mapping of the mh locus: double-muscling in the Asturiana de los Valles breed involves the same locus as in the Belgian Blue cattle breed.

Dunner, S.; Charlier, Carole; Farnir, Frédéric et al.

1997 • In Mammalian Genome, 8 (6), p. 430-5

Peer Reviewed verified by ORBi

Permalink
https://hdl.handle.net/2268/34404

DOI
10.1007/s003359900462

PubMed
9166589

Files (1)Send to Details Statistics Bibliography Similar publications

Files

Full Text

DunnerS-MammGen-1997.pdf

Publisher postprint (892.4 kB)

Request a copy

All documents in ORBi are protected by a user license.

Send to

RIS BibTex APA Chicago Permalink X Linkedin

Details

Keywords :

Animals; Belgium; Breeding; Cattle/genetics; Chromosome Mapping; Chromosomes; Female; Genetic Linkage/genetics; Genetic Markers; Hypertrophy/genetics; Linkage Disequilibrium; Male; Microsatellite Repeats; Muscles/abnormalities; Spain

Abstract :

[en] The Spanish "Asturiana" cattle breed is characterized by the segregation of a genetically determined muscular hypertrophy referred to as double-muscling or "culones". We demonstrate by linkage analysis that this muscular hypertrophy involves the mh locus previously shown to cause double-muscling in the Belgian Blue cattle breed, pointing towards locus homogeneity of this trait across both breeds. Moreover, using a twopoint and multipoint maximum likelihood approach, we show that flanking microsatellite markers are in linkage disequilibrium with the mh locus in both breeds albeit with different alleles. Finally, we discuss how allelic homogeneity across breeds might be exploited to achieve efficient genetic fine-mapping of the mh locus.

Disciplines :

Veterinary medicine & animal health
Genetics & genetic processes

Author, co-author :

Dunner, S.

Charlier, Carole ; Université de Liège - ULiège > Département de productions animales > Biostatistiques et bioinformatique appliquées aux sc. vétér.

Farnir, Frédéric ; Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement

Brouwers, Benoît

Canon, J.; Université de Liège - ULiège > CSL (Centre Spatial de Liège)

Georges, Michel ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Language :

English

Title :

Towards interbreed IBD fine mapping of the mh locus: double-muscling in the Asturiana de los Valles breed involves the same locus as in the Belgian Blue cattle breed.

Publication date :

1997

Journal title :

Mammalian Genome

ISSN :

0938-8990

eISSN :

1432-1777

Publisher :

Springer Verlag, New York, United States - New York

Volume :

Issue :

Pages :

430-5

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 January 2010

Statistics

Number of views

91 (4 by ULiège)

Number of downloads

1 (1 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Barendse W, Armitage SM, Kossarek LM, Shalom A, Kirkpatrick BW, Ryan AM, Clayton D, Li L, Neibergs HL, Zhang N, Grosse WM, Weiss J, Creighton P, McCarthy F, Ron M, Teale AJ, Fries R, McGraw RA, Moore SS, Georges M, Soller M, Womack JE, Hetzel DJS (1944) A genetic linkage map of the bovine genome. Nature Genetics 6, 227-235
Bishop MD, Kappes SM, Keele JW, Stone RT, Sunden SLF, Hawkins GA, Solinas Toldo S, Fries R, Grosz, MD, Yoo J, Beattie CW (1994) A genetic linkage map for cattle. Genetics 136, 619-639
Boehnke M (1994) Limits of resolution of linkage studies: implications for the positional cloning of disease genes. Am J Hum Genet 55, 379-390
Canon J, Gutierez JP, Dunner S, Goyache F, Vallejo M (1994) Herdbook analyses of the Asturiana beef cattle breeds. Genet Select Evol 26, 65-75
Charlier C, Coppieters W, Farnir F, Grobet L, Leroy P, Michaux C, Mni M, Schwers A, Vanmanshoven P, Hansel R, Georges M (1995) The mh gene causing double-muscling in cattle maps to bovine chromosome 2. Mammalian Genome 6, 788-792
Cottingham RW, Idury RM, Schäffer AA (1993) Faster sequential genetic linkage compulations. Am J Hum Genet 53, 252-263
Culley G (1807) Observations on livestock. 4th ed. London, G. Woodfall
Dunner S, Canon J, Gutierez JP, Vallejo M, Alonso L, Goyache F (1993a) La race bovine Asturienne des Vallées. Animal Genetic Resources Information 11, 75-84
Dunner S, Canon J, Gutierez JP, Vallejo M, Alonso L, Goyache F (1993b) La race bovine Asturienne des Montagnes. Animal Genetic Resources Information 11, 85
Georges M, Nielsen D, Mackinnon M, Mishra A, Okimoto R, Pasquino AT, Sargeant LS, Sorensen A, Steele MR, Zhao X, Womack JE, Hoeschele I (1995) Mapping quantitative trait loci controlling milk production by exploiting progeny testing. Genetics 139, 907-920
Georges M, Andersson L (1996) Livestock genomics comes of age. Genome Research 10, 907-921
Goyache F (1995) Influencia de efectos sistematicos sobre los caracteres de importancia economica en la raza Asturiana de los Valles, PhD Thesis. Universidad Complutense de Madrid
Hanset R, Michaux C, Dessy-Doize C, Burtonboy G (1982) Studies on the 7th rib in double muscled and conventional cattle. In Current Topics in Veterinary Medicine and Animal Science, vol. 16: Muscle hypertrophy of genetic origin and its use to improve beef production. Ed. King and Ménissier, Martinus Nijhoff. pp 341-349
Hansel R, Michaux C (1985a) On the genetic determinism of muscular hypertrophy in the Belgian White and Blue cattle breed. I. Experimental data. Génét Sél Evol 17, 359-368
Hanset R, Michaux C (1985b) On the genetic determinism of muscular hypertrophy in the Belgian White and Blue cattle breed. II. Population data. Genet Sél Evol 17, 369-386
Lathrop M, Lalouel JM (1984) Easy calculations of lodscores and genetic risk on small computers. Am J Hum Genet 36, 460-465
Ma RZ, Beever JE, Da Y, Green CA, Russ I, Park C, Heyen DW, Everts RE, Fisher SR, Overton KM, Teale AJ, Kemp SJ, Hines HC, Guérin G, Lewin HA (1996) A male linkage map of the cattle (Bos taurus) genome. J Heredity (in press)
Ménissier F (1982) Present state of knowledge about the genetic determination of muscular hypertrophy or the double museled trait in cattle. In Current Topics in Veterinary Medicine and Animal Science, vol. 16: Muscle hypertrophy of genetic origin and its use to improve beef production. Ed. King and Ménissier, Martinus Nijhoff, pp 387-428
Sopena Quesada A, Blanco Cachafeiro ME (1971) Reproduction de la femelle cularde en race Asturienne. In: 22° Réunion Annuelle, Fédération Européenne de Zootechnie, Paris-Versailles, Juillet 1971. Ann Génét Sél Anim 4, 132
Terwilliger JD (1995) A powerful likelihood method tor the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci. Am J Hum Genet 56, 777-787
Vaiman D, Mercier D, Moazami-Goudarzi K, Eggen A, Ciampolini R, Lépingle A, Velmala R, Kaukinen J, Varvio SL, Martin P, Levéziel H, Guérin G (1994) A set of 99 cattle microsatellites: characterization, synteny mapping and polymorphism. Mammalian Genome 5, 288-297
Vallejo M, Guttierez JP, Alonso L, Canon J, Revuelta JR, Goyache F, Cima M (1992) Caracteristicas de las canales de las Razas Bovinas Asturianas. II. Valoracion cuantitativa y prediccion de la composicion tisular en la raza Asturiana de la Montana. Arch Zootec 41, 645-656
Vallejo M, Guttierez JP, Cima M, Canon J, Alonso L, Revuelta JR, Goyache F (1993) Caracteristicas de las canales de las Razas Bovinas Asturianas. II. Valoracion cuantitativa y prediccion de la composicion tisular en la raza Asturiana de los Valles. Arch Zootec 42, 29-40