[en] Twelve animals affected with syndactyly or mulefoot were sampled in the Dutch black-and-white cattle population. Analysis of the pedigree data reveal that all of these individuals traced back to a single acknowledged carrier founder individual. Between seven and nine generations separated the founder from its 12 affected descendents. The 12 affected offspring were genotyped for a battery of 213 microsatellites spanning the 29 bovine autosomes. The resulting genotypes were analyzed using a maximum likelihood approach searching for shared homozygous haplotypes among affected individuals. Three candidate regions for the syndactyly locus emerged from this initial screening. syndactyly was shown to map to one of these candidate regions on chromosome 15 by genotyping 29 additional individuals linking founder and affected offspring and performing a conventional linkage analysis with the LINKAGE programs. This study illustrates the potential of identity-by-descent mapping in livestock populations.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Charlier, Carole ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Farnir, Frédéric ; Université de Liège - ULiège > Département de productions animales > Biostatistique, économie, sélection animale
Berzi, P.
Vanmanshoven, P.
Brouwers, B.
Georges, Michel ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Language :
English
Title :
IBD mapping of recessive traits in livestock: application to map the bovine syndactyly locus to chromosome 15
Publication date :
1996
Journal title :
Genome Research
ISSN :
1088-9051
eISSN :
1549-5469
Publisher :
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, United States - New York
Barendse, W., S.M. Armitage, L.M. Kossarek, A. Shalom, B.W. Kirkpatrick, A.M. Ryan, D. Clayton, L. Li, H.L. Neibergs, N. Zhang, W.M. Grosse, J. Weiss, P. Creighton, F. McCarthy, M. Ron, A.J. Teale, R. Fries, R.A. McGraw, S.S. Moore, M. Georges, M. Soller, J.E. Womack, and D.J.S. Hetzel. 1994. A genetic linkage map of the bovine genome. Nature Genet. 6: 227-235.
Bishop, M.D., S.M. Kappes, J.W. Keele, R.T. Stone, S.L.F. Sunden, G.A. Hawkins, S. Solinas-Toldo, R. Fries, M.D. Grosz, J. Yoo, and C.W. Beattie. 1994. A genetic linkage map for cattle. Genetics 136: 619-639.
Cottingham, R.W., R.M. Idury, and A.A. Schäffer. 1993. Faster sequential genetic linkage computations. Am. J. Hum. Genet. 53: 252-263.
Eldridge, F.E., W.H. Smith, and W.M. McLeod. 1951. Syndactylism in Holstein-Friesian cattle. J. Hered. 42: 241-250.
Fuji, J., K. Otsu, F. Zorzato, S. Deleon, V.K. Khanna, J.E. Weiler, P.J. O'Brien, and D.H. MacLennan. 1991. Identification of a mutation in the porcine ryanodine receptor associated with malignant hyperthermia. Science 253: 448-451.
Georges, M., M. Lathrop, A.B. Dietz, A. Lefort, F. Libert, A. Mishra, D. Nielsen, L.S. Sargeant, M.R. Steele, X. Zhao, H. Leipold, and J.E. Womack. 1993. Microsatellite mapping of the gene causing weaver disease in cattle will allow the study of an associated QTL. Proc. Natl. Acad. Sci. 90: 1058-1062.
Georges, M., D. Nielsen, M. Mackinnon, A. Mishra, R. Okimoto, A.T. Pasquino, L.S. Sargeant, A. Sorensen, M.R. Steele, X. Zhao, J.E. Womack, and I. Hoeschele. 1995. Mapping quantitative trait loci controlling milk production by exploiting progeny testing. Genetics 139: 907-920.
Gilbert, S.F. 1994. Development of the tetrapod limb. In Developmental biology, 4th ed., pp. 690-715. Sinauer Associates, Inc., Sunderland, MA.
Hart-Elcock, L., H.W. Leipold, and R. Baker. 1987. Hereditary bovine syndactyly: Diagnosis in bovine fetuses. Vet. Pathol. 24: 140-147.
Hästbacka, J., A. de la Chapelle, I. Kaitila, P. Sistonen, A. Weaver, and E. Lander. 1992. Linkage disequilibrium mapping in isolated founder populations: Diastrophic dysplasia in Finland. Nature Genet. 2: 204-211.
Hoeschele, I. and T.R. Meinert. 1990. Association of genetic defects with yield and type traits: The Weaver locus effect on yield. J. Dairy Sci. 73: 2503-2515.
Houvven, R.H.J., S. Baharloo, K. Blankenship, P. Raeymaekers, J. Juyn, L.A. Sandkuijl, and N.B. Freimer. 1995. Genome screening by searching for shared segments: Mapping a gene for benign recurrent intrahepatic cholestasis. Nature Genet. 8: 380-386.
Kruglyak, L., M.J. Daly, and E. Lander. 1995. Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping. Am. J. Hum. Genet. 56: 519-527.
Kruglyak, L. and E. Lander. 1995. High-resolution genetic mapping of complex traits. Am. J. Hum. Genet. 56: 1212-1223.
Lander, E.S. and D. Botstein. 1987. Homozygosity mapping: A way to map human recessive traits with the DNA of inbred children. Science 236: 1567-1570.
Lathrop, M.and J.M. Lalouel. 1984. Easy calculation sof lod scores and genetic risk on small computers. Am. J. Hum. Genet. 36: 460-465.
Leipold, H.W., K. Huston, D.M. Trotter, S.M. Dennis, and M.M. Guffy. 1969. Anatomy of hereditary bovine syndactylism. I. Osteology. J. Dairy Sci. 52: 1422-1431.
Leipold, H.W., S.M. Dennis, and K. Huston. 1973. Syndactyly in cattle. Vet. Bull. 43: 399-403.
Ma, R.Z., J.E. Beever, Y. Da, C.A. Green, I. Russ, C. Park, D.W. Heyen, R.E. Everts, S.R. Fisher, K.M. Overton, A.J. Teale, S.J. Kemp, H.C. Hines, G. Guerin, and H.A. Lewin. 1996. A male linkage map of cattle (Bos taurus) genome. J. Hered. (in press).
Mulvihill, J.J. 1995. Craniofacial syndromes: No such thing as a single gene disease. Nature Genet. 9: 101-103.
O'Brien, S.J., J.E. Womack, L.A. Lyons, K.J. Moore, N.A. Jenkins, and N.G. Copeland. 1993. Anchored reference loci for comparative genome mapping in mammals. Nature Genet. 3:103-112.
Puffenberger, E.G., E.R. Kauffman, S. Bolk, T.C. Matise, S.S. Washington, M. Angrist, J. Weissenbach, K.L. Garver, M. Mascari, R. Ladda, et al. 1994. Identity-by-descent and association mapping of a recessive gene for Hirschprung disease on human chromosome 13q22. Hum. Mol. Genet. 3: 1217-1225.
Roberts, D.J. and C. Tabin. 1994. The genetics of human limb development. Am. J. Hum. Genet. 55: 1-6.
Solinas-Toldo, S., C. Lengauer, and R. Fries. 1995. Comparative genome map of human and cattle. Genomics 27: 489-496.