[en] A genetic disease in cattle, progressive degenerative myeloencephalopathy (weaver disease), is associated with increased milk production. This association could result from population stratification, from a pleiotropic effect of a single gene, or from linkage disequilibrium between the gene causing weaver disease and a quantitative trait locus (QTL) for milk production. To test these hypotheses, we performed an extensive linkage study in a bovine pedigree segregating for the weaver condition and identified a microsatellite locus (TGLA116) closely linked to the weaver gene (zmax, 8.15; theta, 0.03). TGLA116 and, by extension, the weaver locus were assigned to bovine synteny group 13. This microsatellite can be used to identify weaver carriers, to select against this genetic defect, and to study the effect of the corresponding chromosomal region on milk production in Brown Swiss and other breeds of cattle.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Georges, Michel ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Lathrop, M.
Dietz, A. B.
Lefort, A.
Libert, F.
Mishra, A.
Nielsen, D.
Sargeant, L. S.
Steele, M. R.
Zhao, X.
Leipold, H.
Womack, J. E.
Language :
English
Title :
Microsatellite mapping of the gene causing weaver disease in cattle will allow the study of an associated QTL
Publication date :
1993
Journal title :
Proceedings of the National Academy of Sciences of the United States of America
ISSN :
0027-8424
eISSN :
1091-6490
Publisher :
National Academy of Sciences, Washington, United States - District of Columbia
Arnheim, N., Strange, C. & Erlich, H. (1985) Proc. Natl. Acad. Sci. USA 82, 6970-6974.
Lander E. S. & Botstein, D. (1989) Genetics 121, 185-199.
Lathrop, G. M., Lalouel, J. M., Julier, C. & Ott, J. (1984) Proc. Natl. Acad. Sci. USA 81, 3443-3446.
Rudolph, J. A., Spier, S. J., Byrns, G., Rojas, C. V., Bernoco, D. & Hoffman, E. P. (1992) Nature Genet. 2, 144-147.
MacLennan, D. H. & Phillips, M. S. (1992) Science 256, 789-794.
Hoeschele, I. & Meinert, T. R. (1990) J. Dairy Sci. 73, 2503-2515.
Leipold, H. W., Blaugh, B., Huston, K., Edgerly, C. G. M. & Hibbs, C. M. (1973) Vet. Med. Small Anim. Clin. 68, 645-647.
Stuart, L. D. & Leipold, H. W. (1983) Bovine Pract. 18, 129-132.
Stuart, L. D. & Leipold, H. W. (1983) Bovine Pract. 18, 133-146.
Stuart, L. D. & Leipold, H. W. (1985) Vet. Pathol. 22, 13-23.
Oyster, R., Leipold, H. W., Troyer, D. & Cash, W. (1991) Prog. Vet. Neurol. 2, 159-164.
Steele, M. R. & Georges, M. (1991) Genomics 10, 889-904.
Georges, M., Gunawardana, A., Threadgill, D., Lathrop, M., Olsaker, I., Mishra, A., Sargeant, L., Schoeberlein, A., Steele, M., Terry, C., Threadgill, D., Zhao, X., Holm, T., Fries, R. & Womack, J. (1991) Genomics 11, 24-32.
Georges, M. & Massey, J. (1992) Polymorphic DNA Markers in Bovidae (World Intellectual Property Org., Geneva), WO Publ. No. 92/13102.
Lathrop, G. M. & Lalouel, J.-M. (1984) Am. J. Hum. Genet. 36, 460-465.
Womack, J. E. & Moll, Y. D. (1986) J. Hered. 77, 2-7.
Chevalet, C. & Corpet, F. (1986) Cytogenet. Cell Genet. 43, 132-139.
Dietz, A. B., Neibergs, H. L. & Womack, J. E. (1992) Mammal. Genome 3, 106-111.
Cannings, C., Thompson, E. A. & Skolnick, M. H. (1978) Adv. Appl. Prob. 10, 26-61.
Thomas, D. C. (1992) Cytogenet. Cell Genet. 59, 228-230.
Lange, K. & Sobel, E. (1991) Am. J. Hum. Genet. 49, 1320-1334.
Womack, J. E., Threadgill, D. W., Moll, Y. D., Faber, L. K., Foreman, M. L., Dietz, A. B., Tobin, T. C., Skow, L. C., Zneimer, S. M., Gallagher, D. S. & Rogers, D. S. (1989) Cytogenet. Cell Genet. 51, 1109.
Womack, J. E., Dietz, A. B., Gallagher, D. S., Li, L., Nan, Z., Neibergs, H. L., Moll, Y. D. & Ryan, A. M. (1991) Cytogenet. Cell Genet. 58, 2132.
Li, L., Teale, A., Bensaid, A., Dunlap, S., Dietz, A. B. & Womack, J. E. (1992) Immunogenetics 36, 224-229.
Lyon, M. & Searle, A. G., eds. (1989) Genetic Variants and Strains of the Laboratory Mouse (Oxford Univ. Press, Oxford).
