2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide: evaluation of the spin trapping properties

[en] The 2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-l-oxide (EMPO), an easily prepared pyrroline-Noxide has been tested as a free radical scavenger. Spin adducts of superoxide, hydroxyl radical, and other free radicals were characterized in phosphate buffer at pH 7.0 and 5.6. At pH 7 in phosphate buffer, the EMPO/O2 2• spin adduct was estimated to be about five times more persistent than its DMPO analogue. Furthermore, its decay does not produce the EMPO/HO• adduct.

Disciplines :

Chemistry

Author, co-author :

Olive, Gilles ; Université de Liège - ULiège > Gembloux Agro-Bio Tech

Mercier, Anne

Le Moigne, François

Rockenbauer, Antal

Tordo, Paul

Language :

English

Title :

2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide: evaluation of the spin trapping properties

Publication date :

2000

Journal title :

Free Radical Biology and Medicine

ISSN :

0891-5849

eISSN :

1873-4596

Publisher :

Elsevier Science, Tarrytown, United States - New York

Volume :

Issue :

Pages :

403-408

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 22 February 2010

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142

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