Assessment of health effects of potato crop phytopharmaceuticals and storage products in a murine model

[en] Potatoes are among the most widely consumed staple foods worldwide, but their cultivation and storage frequently involve multiple phytopharmaceutical products (PPPs), raising concerns about the health risks of dietary pesticide residues. The health effects of multi-residue PPPs used in potato cultivation were assessed in an in vivo murine model, involving 36 mice, and evaluated through omics analyses. Two field cultivation methods (conventional and organic) and two post-harvest storage conditions (using 1,4-dimethylnaphthalene and mint essential oil as sprout inhibitor treatments) were considered. Potato tubers were processed into flour and administered to the animals at a moderate daily dose for 20 consecutive days.

Research Center/Unit :

TERRA Research Centre. Microbial, food and biobased technologies - ULiège
FARAH. Santé publique vétérinaire - ULiège

Disciplines :

Agriculture & agronomy

Author, co-author :

Theysgeur, Sandy ; Université de Liège - ULiège > Département GxABT > Microbial technologies

Dugardin, Camille

Louvel, Brice

Lemière, Sébastien

Muchembled, Jérôme

Taminiau, Bernard ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Santé publique vétérinaire

Daube, Georges ; Université de Liège - ULiège > Département de sciences des denrées alimentaires (DDA) > Microbiologie des denrées alimentaires

Siah, Ali

Ravallec, Rozenn

Hilbert, Jean-Louis

Lucau-Danila, Anca

Language :

English

Title :

Assessment of health effects of potato crop phytopharmaceuticals and storage products in a murine model

Publication date :

November 2025

Journal title :

Science of the Total Environment

ISSN :

0048-9697

eISSN :

1879-1026

Publisher :

Elsevier

Volume :

1002

Pages :

180630

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0048969725022703?httpAccept=text/xml

Available on ORBi :

since 07 October 2025

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Bibliography

Afolabi, O.K., Aderibigbe, F.A., Folarin, D.T., Arinola, A., Wusu, A.D., Oxidative stress and inflammation following sub-lethal oral exposure of cypermethrin in rats: mitigating potential of epicatechin. Heliyon, 5(8), 2019, e02274, 10.1016/j.heliyon.2019.e02274.
Agreste, Les chiffres de la filière pomme de terre en France. 2022, Ministère de l'Agriculture et de la Souveraineté Alimentaire https://agreste.agriculture.gouv.fr.
Balce, D.R., Wang, Y.T., McAllaster, M.R., Dunlap, B.F., Orvedahl, A., Hykes, B.L. Jr., Droit, L., Handley, S.A., Wilen, C.B., Doench, J.G., Orchard, R.C., Stallings, C.L., Virgin, H.W., UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages. Proc. Natl. Acad. Sci. USA, 118(1), 2021, e2011763118, 10.1073/pnas.2011763118.
Barlow, G.M., Yu, A., Mathur, R., Role of the gut microbiome in obesity and diabetes mellitus. Nutr. Clin. Pract. 30 (2015), 787–797.
Blumenthal, M., Busse, W.R., (eds.) The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines, 1999, American Botanical Council.
Boobis, A.R., Ossendorp, B.C., Banasiak, U., Hamey, P.Y., Sebestyen, I., Moretto, A., Cumulative risk assessment of pesticide residues in food. Toxicol. Lett. 180:2 (2008), 137–150, 10.1016/j.toxlet.2008.06.004.
Cai, S., Sun, P.-H., Resaul, J., Shi, L., Jiang, A., Satherley, L.K., Davies, E.L., Ruge, F., Douglas-Jones, A., Jiang, W.G., Ye, L., Expression of phospholipase C isozymes in human breast cancer and their clinical significance. Oncol. Rep. 37:3 (2017), 1707–1715, 10.3892/or.2017.5394.
Campbell, M.A., Gleichsner, A., Alsbury, R., Horvath, D., Suttle, J., The sprout inhibitors chlorpropham and 1,4-dimethylnaphthalene elicit different transcriptional profiles and do not suppress growth through a prolongation of the dormant state. Plant Mol. Biol. 73:1–2 (2010), 181–189, 10.1007/s11103-010-9607-6.
Cao, Y.G., Bae, S., Villarreal, J., Moy, M., Chun, E., Michaud, M., Lang, J.K., Glickman, J.N., Lobel, L., Garrett, W.S., Faecalibaculum rodentium remodels retinoic acid signaling to govern eosinophil-dependent intestinal epithelial homeostasis. Cell Host Microbe 30:9 (2022), 1295–1310.e8, 10.1016/j.chom.2022.07.015.
de Castro, R.O., Carbajal, A., Previato de Almeida, L., et al. Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development. Epigenetics Chromatin, 15, 2022, 16, 10.1186/s13072-022-00448-5.
Cavalier, H., Trasande, L., Porta, M., Exposures to pesticides and risk of cancer: evaluation of recent epidemiological evidence in humans and paths forward. Int. J. Cancer 152:5 (2023), 879–912, 10.1002/ijc.34300.
Cedergreen, N., Quantifying synergy: a systematic review of mixture toxicity studies within environmental toxicology. PLoS One, 9(5), 2014, e96580, 10.1371/journal.pone.0096580.
Chen, G., Cheng, Y., Zhang, Z., Martinka, M., Li, G., Cytoplasmic Skp2 expression is increased in human melanoma and correlated with patient survival. PLoS One, 6(2), 2011, e17578, 10.1371/journal.pone.0017578.
Davidse, L.C., Looijen, D., Turkensteen, L.J., van der Wal, D., Occurrence of metalaxyl-resistant trains of Phytophthora infestans in Dutch potato fields. Neth. J. Plant Pathol. 87 (1981), 65–68, 10.1007/BF01976658.
Devi, R., Sharma, S.P., Kumari, A., Pesticides contamination in potatoes and associated health risk to population with respect detection limits. Int. J. Food Sci. Nutr. 3:5 (2018), 144–147 http://www.foodsciencejournal.com.
Djari, C., Sahut-Barnola, I., Septier, A., Plotton, I., Montanier, N., Dufour, D., Levasseur, A., Wilmouth, J. Jr., Pointud, J.C., Faucz, F.R., Kamilaris, C., Lopez, A.G., Guillou, F., Swain, A., Vainio, S.J., Tauveron, I., Val, P., Lefebvre, H., Stratakis, C.A., Martinez, A., Lefrançois-Martinez, A.M., Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex. J. Clin. Invest., 131(23), 2021, e146910, 10.1172/JCI146910.
Du, Z., Wen, X., Wang, Y., et al. Chromatin lncRNA Platr10 controls stem cell pluripotency by coordinating an intrachromosomal regulatory network. Genome Biol., 22, 2021, 233, 10.1186/s13059-021-02444-6.
Dunleavy, J.E.M., Okuda, H., O'Connor, A.E., Merriner, D.J., O'Donnell, L., Jamsai, D., et al. Katanin-like 2 (KATNAL2) functions in multiple aspects of haploid male germ cell development in the mouse. PLoS Genet., 13(11), 2017, e1007078, 10.1371/journal.pgen.1007078.
EFSA, The 2018 European Union report on pesticide residues in food. EFSA J., 18(4), 2020, e06057, 10.2903/j.efsa.2020.6057.
EFSA, European Food Safety Authority, Conclusion on the peer review of the pesticide risk assessment of the active substance 1,4-dimethylnaphthalene. EFSA J., 10(4), 2012, 2666, 10.2903/j.efsa.2012.2666.
EFSA, European Food Safety Authority, Peer review of the pesticide risk assessment of the active substance carfentrazone-ethyl. EFSA J., 14(8), 2016, 4569, 10.2903/j.efsa.2016.4569.
EFSA, European Food Safety Authority, Peer review of the pesticide risk assessment of the active substance copper compounds. EFSA J., 16(1), 2018, 5152, 10.2903/j.efsa.2018.5152.
EFSA, European Food Safety Authority, Peer review of the pesticide risk assessment of the active substance metalaxyl-M. EFSA J., 21(5), 2023, 8373, 10.2903/j.efsa.2023.8373.
EFSA, European Food Safety Authority, Arena, M., Auteri, D., Barmaz, S., Bellisai, G., Brancato, A., Brocca, D., Bura, L., Byers, H., Chiusolo, A., Peer review of the pesticide risk assessment of the active substance chlorpropham. EFSA J., 15(7), 2017, 4903, 10.2903/j.efsa.2017.4903.
EFSA Scientific Committee, More, S.J., Bampidis, V., Benford, D., Bennekou, S.H., Bragard, C., Halldorsson, T.I., Schlatter, J., Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals. EFSA J., 17(3), 2019, 5634, 10.2903/j.efsa.2019.5634.
Elsøe, S., Christoffersen, C., Luchoomun, J., Turner, S., Nielsen, L.B., Apolipoprotein M promotes mobilization of cellular cholesterol in vivo. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1831:7 (2013), 1287–1292, 10.1016/j.bbalip.2013.04.009.
EPA, U.S. Environmental Protection Agency, 1,4-Dimethylnaphthalene: Pesticide Fact Sheet. 2003, U.S. Environmental Protection Agency.
EPA, U.S. Environmental Protection Agency, Pesticide fact sheet: Amisulbrom (PC Code: 016330). https://www3.epa.gov/fs_PC-016330_16-sep-11, 2011.
Falero, C., Huanca, W., Barrios-Arpi, L., Lira-Mejía, B., Ramos-Coaguila, O., Torres, E., Ramos, E., Romero, A., Ramos-Gonzalez, M., Oxidative and molecular–structural alterations of spermatozoa in swine and ram exposed to the triazole ipconazole. Toxics, 13(3), 2025, 176, 10.3390/toxics13030176.
FAO, FAOSTAT — crops and livestock products. https://www.fao.org/faostat/en/#data/QCL, 2023.
FAO/WHO, Pesticide residues in food — 2009: evaluations 2009. Joint FAO/WHO Meeting on Pesticide Residues (JMPR), FAO Plant Production and Protection Paper 198, 2009, Food and Agriculture Organization of the United Nations/World Health Organization.
Fernandes, A.D., Vu, M.T.H.Q., Edward, L.-M., Macklaim, J.M., Gloor, G.B., A reproducible effect size is more useful than an irreproducible hypothesis test to analyze high throughput sequencing datasets [preprint]. arXiv, 2018, 10.48550/arXiv.1809.02623.
Fiorentino, T.V., De Vito, F., Suraci, E., Marasco, R., Hribal, M.L., Luzza, F., Sesti, G., Obesity and overweight are linked to increased sodium-glucose cotransporter 1 and glucose transporter 5 levels in duodenum. Obesity 31:4 (2023), 1101–1107, 10.1002/oby.23653.
Foure, M., Dugardin, C., Foligné, B., Hance, P., Cadalen, T., Delcourt, A., Chapelet, M., Guérin, S., Rémond, D., Durand, S., Cudennec, B., Chicory roots for prebiotics and appetite regulation: a pilot study in mice. J. Agric. Food Chem. 66:25 (2018), 6439–6449, 10.1021/acs.jafc.8b01055.
Garry, V.F., Schreinemachers, D., Harkins, M.E., Griffith, J., Birth defects, season of conception, and sex of children born to pesticide applicators living in the Red River Valley of Minnesota, USA. Environ. Health Perspect. 109:5 (2002), 605–611.
Gérard, A., El-Hajjaji, S., Burteau, S., Fall, P.A., Pirard, B., Taminiau, B., Daube, G., Sindic, M., Study of the microbial diversity of a panel of Belgian artisanal cheeses associated with challenge studies for Listeria monocytogenes. Food Microbiol., 100, 2021, 103861, 10.1016/j.fm.2021.103861.
Gómez-Castillo, D., Cruz, E., Iguaz, A., Arroqui, C., Vírseda, P., Effects of essential oils on sprout suppression and quality of potato cultivars. Postharvest Biol. Technol. 82 (2013), 15–21, 10.1016/j.postharvbio.2013.02.017.
Gorshkova, I.N., Atkinson, D., Enhanced binding of apolipoprotein A–I variants associated with hypertriglyceridemia to triglyceride-rich particles. Biochemistry 50:12 (2011), 2040–2047, 10.1021/bi200158b.
Gower, J.R., Some distance properties of latent root and vector methods used in multivariate analysis. Biometrika 53:3–4 (1966), 325–338, 10.1093/biomet/53.3-4.325.
Grove, M., Kim, H., Pang, S., Paz Amaya, J., Hu, G., Zhou, J., Lemay, M., Son, Y.-J., TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves. eLife, 13, 2024, e87394, 10.7554/eLife.87394.
Ha, N.T., Lee, C.H., Roles of farnesyl-diphosphate farnesyltransferase 1 in tumour and tumour microenvironments. Cells, 9(11), 2020, 2352, 10.3390/cells9112352.
Han, X., Zhang, A., Wang, P., Bi, H., Ren, K., Li, E., et al. Pleckstrin-2 mediates the activation of AKT in prostate cancer and is repressed by androgen receptor. Am. J. Pathol. 194:10 (2024), 1986–1996, 10.1016/j.ajpath.2024.07.004.
Hassanen, E.I., Issa, M.Y., Hassan, N.H., Ibrahim, M.A., Fawzy, I.M., Fahmy, S.A., Mehanna, S., Potential mechanisms of imidacloprid-induced neurotoxicity in adult rats with attempts on protection using Origanum majorana L. oil/extract: in vivo and in silico studies. ACS Omega 8:21 (2023), 18491–18508, 10.1021/acsomega.2c08295.
Hernández, A.F., Tsatsakis, A.M., Human exposure to chemical mixtures: challenges for the integration of toxicology with epidemiology data in risk assessment. Food Chem. Toxicol. 103 (2017), 188–193, 10.1016/j.fct.2017.03.012.
Hjeij, R., Aprea, I., Poeta, M., Nöthe-Menchen, T., Bracht, D., Raidt, J., Honecker, B.I., Dougherty, G.W., Olbrich, H., Schwartz, O., et al. Pathogenic variants in CLXN encoding the outer dynein arm docking-associated calcium-binding protein calaxin cause primary ciliary dyskinesia. Genet. Med., 25(5), 2023, 100798, 10.1016/j.gim.2023.100798.
Huang, M., Zheng, J., Chen, L., You, S., Huang, H., Role of apolipoproteins in the pathogenesis of obesity. Clin. Chim. Acta, 545, 2023, 117359, 10.1016/j.cca.2023.117359.
Jiang, M.C., Ni, J.J., Cui, W.Y., Wang, B.Y., Zhuo, W., Emerging roles of lncRNA in cancer and therapeutic opportunities. Am. J. Cancer Res. 9:7 (2019), 1354–1366 PMCID: PMC6682721.
Kamel, F., Hoppin, J.A., Association of pesticide exposure with neurologic dysfunction and disease. Environ. Health Perspect. 112:9 (2004), 950–958.
Kim, H., Ekram, M.B., Bakshi, A., Kim, J., AEBP2 as a transcriptional activator and its role in cell migration. Genomics 105:2 (2015), 108–115, 10.1016/j.ygeno.2014.11.007.
Koliada, A., Syzenko, G., Moseiko, V., Budovska, L., Puchkov, K., Perederiy, V., et al. Association between body mass index and Firmicutes/Bacteroidetes ratio in an adult Ukrainian population. BMC Microbiol., 17, 2017, 120.
Koop, B.F., Rowen, L., Wang, K., Kuo, C.L., Seto, D., Lenstra, J.A., Howard, S., Shan, W., Deshpande, P., Hood, L., The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. Genomics 19:3 (1994), 478–493, 10.1006/geno.1994.1097.
Kvist, S., Roberts, L., Dobberstein, B., Mouse histocompatibility genes: structure and organisation of a Kd gene. EMBO J. 2:2 (1983), 245–254, 10.1002/j.1460-2075.1983.tb01413.x.
Lamichhane, J.R., Dachbrodt-Saaydeh, S., Kudsk, P., Messéan, A., Toward a reduced reliance on conventional pesticides in European agriculture. Plant Dis. 100:1 (2016), 10–24, 10.1094/PDIS-05-15-0574-FE.
Langouët, M., Saadi, A., Rieunier, G., Moutton, S., Siquier-Pernet, K., Fernet, M., Nitschke, P., Munnich, A., Stern, M.H., Chaouch, M., Colleaux, L., Mutation in TTI2 reveals a role for triple T complex in human brain development. Hum. Mutat. 34:11 (2013), 1472–1476, 10.1002/humu.22399.
Lee, J.V., Shah, S.A., Wellen, K.E., Obesity, cancer, and acetyl-CoA metabolism. Drug Discov. Today Dis. Mech. 10:1–2 (2013), e55–e61, 10.1016/j.ddmec.2013.03.005.
Li, Z., Fantke, P., Considering degradation kinetics of pesticides in plant uptake models: proof of concept for potato. Pest Manag. Sci. 79:4 (2023), 1154–1163, 10.1002/ps.7288.
Merzendorfer, H., Chitin synthesis inhibitors: old molecules and new developments. Insect Sci. 20:2 (2013), 121–138, 10.1111/j.1744-7917.2012.01535.x.
Mesnage, R., Antoniou, M.N., Ignoring adjuvant toxicity falsifies the safety profile of commercial pesticides. Front. Public Health, 5, 2018, 361, 10.3389/fpubh.2017.00361.
Mesnage, R., Benbrook, C., Antoniou, M.N., Insight into the confusion over surfactant co-formulants in glyphosate-based herbicides. Food Chem. Toxicol. 128 (2019), 137–145, 10.1016/j.fct.2019.03.053.
Mesnage, R., Bowyer, R.C.E., El Balkhi, S., et al. Impacts of dietary exposure to pesticides on faecal microbiome metabolism in adult twins. Environ. Health, 21, 2022, 46, 10.1186/s12940-022-00860-0.
Mostafalou, S., Abdollahi, M., Pesticides: an update of human exposure and toxicity. Arch. Toxicol. 91:2 (2017), 549–599, 10.1007/s00204-016-1849-x.
Muona, M., Ishimura, R., Laari, A., Ichimura, Y., Linnankivi, T., Keski-Filppula, R., Herva, R., Rantala, H., Paetau, A., Pöyhönen, M., et al. Biallelic variants in UBA5 link dysfunctional UFM1 ubiquitin-like modifier pathway to severe infantile-onset encephalopathy. Am. J. Hum. Genet. 99:3 (2016), 683–694, 10.1016/j.ajhg.2016.06.020.
Nath, S.S., Pandey, C., Roy, D., A near fatal case of high dose peppermint oil ingestion—lessons learnt. Indian J. Anaesth. 56:6 (2012), 582–584, 10.4103/0019-5049.104590.
NCBI, National Center for Biotechnology Information, PubChem compound summary for CID 86222, Carfentrazone-ethyl. Retrieved March 21, 2025, from https://pubchem.ncbi.nlm.nih.gov/compound/Carfentrazone-ethyl, 2025.
Noppakun, K., Juntarawijit, C., Association between pesticide exposure and obesity: a cross-sectional study of 20,295 farmers in Thailand. F1000Research, 10, 2021, 445, 10.12688/f1000research.53261.3.
Numata, S., Ueno, S., Iga, J., Song, H., Nakataki, M., Tayoshi, S., Sumitani, S., Tomotake, M., Itakura, M., Sano, A., Ohmori, T., Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population. J. Psychiatr. Res. 43:1 (2008), 7–12, 10.1016/j.jpsychires.2008.01.013.
Official Journal of the European Union, Commission implementing regulation (EU) 2019/989 of 17 June 2019 concerning the non-renewal of approval of the active substance chlorpropham, in accordance with Regulation (EC) No 1107/2009 of the European Parliament and of the Council concerning the placing of plant protection products on the market, and amending the Annex to Commission Implementing Regulation (EU) No 540/2011. Off. J. Eur. Union, L 160, 2019, 11.
Opaliński, Ł., Veenhuis, M., van der Klei, I.J., Peroxisomes: membrane events accompanying peroxisome proliferation. Int. J. Biochem. Cell Biol. 43:6 (2011), 847–851, 10.1016/j.biocel.2011.03.006.
Pandey, S., Osman, T.A., Sharma, S., Vallenari, E.M., Shahdadfar, A., Pun, C.B., Gautam, D.K., Uhlin-Hansen, L., Rikardsen, O., Johannessen, A.C., Costea, D.E., Sapkota, D., Loss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma. Head Neck 42:8 (2020), 2088–2098, 10.1002/hed.26140.
Paulussen, I., Beckert, H., Musial, T.F., Gschossmann, L.J., Wolf, J., Schmitt, M., Clasadonte, J., Mairet-Coello, G., Wolff, C., Schoch, S., Dietrich, D., SV2B defines a subpopulation of synaptic vesicles. J. Mol. Cell Biol., 15(9), 2024, mjad054, 10.1093/jmcb/mjad054.
Rathke, C., Baarends, W.M., Awe, S., Renkawitz-Pohl, R., Chromatin dynamics during spermiogenesis. Biochim. Biophys. Acta 1839:3 (2014), 155–168, 10.1016/j.bbagrm.2013.08.004.
Rognes, T., Flouri, T., Nichols, B., Quince, C., Mahé, F., VSEARCH: a versatile open source tool for metagenomics. PeerJ, 4, 2016, e2584, 10.7717/peerj.2584.
Russell, S., Hall, P., Do septins have a role in cancer?. Br. J. Cancer 93 (2005), 499–503, 10.1038/sj.bjc.6602753.
Sadanari, H., Takemoto, M., Ishida, T., Otagiri, H., Daikoku, T., Murayama, T., Kusano, S., The interferon-inducible human PLSCR1 protein is a restriction factor of human cytomegalovirus. Microbiol. Spectr., 10(1), 2022, e0134221, 10.1128/spectrum.01342-21.
Sahyoun, W., Net, S., Baroudi, M., Ouddane, B., Monitoring of pesticides residues in fruits and vegetables: method optimization and application. Food Biosci., 50, 2022, 102175, 10.1016/j.fbio.2022.102175.
Shannon, C.E., A mathematical theory of communication. Bell Syst. Tech. J. 27:3 (1948), 379–423, 10.1002/j.1538-7305.1948.tb01338.x.
Shannon, C.E., Weaver, W., The Mathematical Theory of Communication. 1949, University of Illinois Press, Urbana, IL.
Sharma, T., Sirpu Natesh, N., Pothuraju, R., Batra, S.K., Rachagani, S., Gut microbiota: a non-target victim of pesticide-induced toxicity. Gut Microbes, 15(1), 2023, 2187578, 10.1080/19490976.2023.2187578.
Shigeishi, H., Higashikawa, K., Hiraoka, M., Fujimoto, S., Mitani, Y., Ohta, K., Takechi, M., Kamata, N., Expression of epiregulin, a novel epidermal growth factor ligand associated with prognosis in human oral squamous cell carcinomas. Oncol. Rep. 19:6 (2008), 1557–1564 (PMID: 18497965).
Skorobogatko, Y., Dragan, M., Cordon, C., Reilly, S.M., Hung, C., Xia, W., Zhao, P., Wallace, M., Lackey, D.E., Chen, X., et al. RalA controls glucose homeostasis by regulating glucose uptake in brown fat. Proc. Natl. Acad. Sci. USA 115:30 (2018), 7819–7824, 10.1073/pnas.1801050115.
Sucharski, H.C., Dudley, E.K., Keith, C.B.R., El Refaey, M., Koenig, S.N., Mohler, P.J., Mechanisms and alterations of cardiac ion channels leading to disease: role of Ankyrin-B in cardiac function. Biomolecules, 10(2), 2020, 211, 10.3390/biom10020211.
Sun, L., Jia, H., Li, J., Yu, M., Yang, Y., Tian, D., Zhang, H., Zou, Z., Cecal gut microbiota and metabolites might contribute to the severity of acute myocardial ischemia by impacting the intestinal permeability, oxidative stress, and energy metabolism. Front. Microbiol., 10, 2019, 1745, 10.3389/fmicb.2019.01745.
Sun, Y., Ren, D., Yang, C., Yang, W., Zhao, J., Zhou, Y., Jin, X., Wu, H., TRIM15 promotes the invasion and metastasis of pancreatic cancer cells by mediating APOA1 ubiquitination and degradation. Biochim. Biophys. Acta Mol. basis Dis., 1867(11), 2021, 166213, 10.1016/j.bbadis.2021.166213.
Tao, K., Chung, M., Watarai, A., Huang, Z., Wang, M.Y., Okuyama, T., Disrupted social memory ensembles in the ventral hippocampus underlie social amnesia in autism-associated Shank3 mutant mice. Mol. Psychiatry 27:4 (2022), 2095–2105, 10.1038/s41380-021-01430-5.
Tseng, Y.-H., Kokkotou, E., Schulz, T.J., Huang, T.L., Winnay, J.N., Taniguchi, C.M., Tran, T.T., Suzuki, R., Espinoza, D.O., Yamamoto, Y., Ahrens, M.J., Dudley, A.T., Norris, A.W., Kulkarni, R.N., Kahn, C.R., New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454:7207 (2008), 1000–1004, 10.1038/nature07221.
Turnbaugh, P.J., Bäckhed, F., Fulton, L., Gordon, J.I., Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 3:4 (2008), 213–223.
Vasiliu, O., Brûlé, J., Doss, M., Benos, P.V., Ultra-low sample size differential expression analysis in microarray studies. PLoS One, 10(1), 2015, e0118198, 10.1371/journal.pone.0118198.
Vigan, M., Essential oils: renewal of interest and toxicity. Eur. J. Dermatol. 20:6 (2010), 685–692, 10.1684/ejd.2010.1066.
Villaorduña, C., Barrios-Arpi, L., Lira-Mejía, B., Ramos-Gonzalez, M., Ramos-Coaguila, O., Inostroza-Ruiz, L., Romero, A., Rodríguez, J.-L., The fungicide ipconazole can activate mediators of cellular damage in rat brain regions. Toxics, 12(9), 2024, 638, 10.3390/toxics12090638.
Wang, S., Li, X., Zhang, Q., Chai, X., Wang, Y., Förster, E., Zhu, X., Zhao, S., Nyap1 regulates multipolar-bipolar transition and morphology of migrating neurons by Fyn phosphorylation during corticogenesis. Cereb. Cortex 30:3 (2020), 929–941, 10.1093/cercor/bhz137.
Wang, S., Ishima, T., Qu, Y., Shan, J., Chang, L., Wei, Y., et al. Ingestion of Faecalibaculum rodentium causes depression-like phenotypes in resilient Ephx2 knock-out mice: a role of brain-gut-microbiota axis via the subdiaphragmatic vagus nerve. J. Affect. Disord. 292 (2021), 565–573, 10.1016/j.jad.2021.06.006.
Weisner, O., Frische, T., Liebmann, L., Reemtsma, T., Roß-Nickoll, M., Schäfer, R.B., et al. Risk from pesticide mixtures — the gap between risk assessment and reality. Sci. Total Environ., 796, 2021, 149017, 10.1016/j.scitotenv.2021.149017.
Wen, L., Ley, R.E., Volchkov, P.V., Stranges, P.B., Avanesyan, L., Stonebraker, A.C., et al. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature, 455(7216), 2008, 1109.
WHO, WHO Monographs on Selected Medicinal Plants. Vols. 1–4, 1999, World Health Organization.
Wołejko, E., Łozowicka, B., Jabłońska-Trypuć, A., Pietruszyńska, M., Wydro, U., Chlorpyrifos occurrence and toxicological risk assessment: a review. Int. J. Environ. Res. Public Health, 19(19), 2022, 12209, 10.3390/ijerph191912209.
Yahia, E., Aiche, M.A., Chouabbia, A., Boulakoud, M.S., Subchronic mancozeb treatment induced liver toxicity via oxidative stress in male Wistar rats. Commun. Agric. Appl. Biol. Sci., 79(3), 2014, 553 Available from https://www.researchgate.net/publication/278794944 [Accessed March 17, 2025].
Yang, Y., Song, X., Wang, G., Xia, Y., Xiong, Z., Ai, L., Understanding Ligilactobacillus salivarius from probiotic properties to omics technology: a review. Foods, 13(6), 2024, 895, 10.3390/foods13060895.
Zhao, H., Cheng, X., Yan, L., et al. APC/C-regulated CPT1C promotes tumor progression by upregulating the energy supply and accelerating the G1/S transition. Cell Commun. Signal., 22, 2024, 283, 10.1186/s12964-024-01657-z.
Zhu, X., Zhang, W., Guo, J., Zhang, X., Li, L., Wang, T., Yan, J., Zhang, F., Hou, B., Gao, N., Gao, G.F., Zhou, X., Noc4L-mediated ribosome biogenesis controls activation of regulatory and conventional T cells. Cell Rep. 27:4 (2019), 1205–1220.e4, 10.1016/j.celrep.2019.03.083.