Meat products consumption and risk for Alzheimer’s dementia and type 2 diabetes: a systematic review and meta-analysis of cohort studies

Li, Mingyu; Yang, Xiaoyue; Sun, Lu; Xiao, Hongwei; Liu, Chongxin; Zhang, Chunjiang; Wang, Zhenyu; Blecker, Christophe; Zhang, Dequan

doi:10.26599/fshw.2024.9250307

Article (Scientific journals)

Meat products consumption and risk for Alzheimer’s dementia and type 2 diabetes: a systematic review and meta-analysis of cohort studies

Li, Mingyu; Yang, Xiaoyue; Sun, Lu et al.

2025 • In Food Science and Human Wellness, 14 (8), p. 9250307

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/335082

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10.26599/fshw.2024.9250307

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Keywords :

Meat products; Meta-analysis; Dose-response analysis; Alzheimer dementia; Type 2 diabetes; Food safety

Abstract :

[en] Alzheimer dementia (AD) and type 2 diabetes (T2D) are interrelated global public health problems, and the current epidemics of both AD and T2D are insulin resistance diseases. Thus, AD and T2D may share common risk factors such as an unhealthy diet, lifestyle, and obesity. Meat products is an important part of the diet of consumers worldwide. This systematic review and meta-analysis aims to assess and estimate the effect of meat products consumption on AD and T2D in humans. Web of Science, MEDLINE, PubMed, Cochrane Library, and Embase were searched from January 2012 to April 2024. 29 articles reported 32 cohort studies with 1,785,769 subjects, with 3,546 AD cases and 91,092 T2D cases that met the inclusion criteria and were included in our analysis. Consumption of various meat products increased the risk of T2D (HR = 1.19, 95% CI: 1.13 - 1.26, p = 0.000; I 2 = 88.5%), consumption of smoked, grilled/roasted and fried meat products was more likely to induce T2D (HR = 1.24, 95% CI: 1.18 - 1.30, p = 0. 000; I 2 = 76.1%), but was borderline significant for the risk of AD (HR = 1.11, 95% CI: 0.98 - 1.25, p = 0.094; I 2 = 58.8%), with consumption of mainly livestock and poultry products increasing the risk (HR = 1.21, 95% CI: 1.03 - 1.42, p = 0.017; I 2 = 66.8%). The association between meat products consumption and AD risk was influenced by meat type and sample size, while the risk of T2D was influenced by meat type, follow-up and sex. A daily intake of 27 g, 123 g and 170 g of livestock products increased the risk of T2D by 10%, 51% and 70% respectively, whereas the risk of T2D was reduced when the intake of various meat products was less than 23 g/d.

Precision for document type :

Review article

Disciplines :

Food science

Author, co-author :

Li, Mingyu ; Université de Liège - ULiège > TERRA Research Centre

Yang, Xiaoyue ; Université de Liège - ULiège > TERRA Research Centre

Sun, Lu ; Université de Liège - ULiège > TERRA Research Centre

Xiao, Hongwei

Liu, Chongxin

Zhang, Chunjiang

Wang, Zhenyu

Blecker, Christophe ; Université de Liège - ULiège > TERRA Research Centre > Technologie Alimentaire (TA)

Zhang, Dequan

Language :

English

Title :

Meat products consumption and risk for Alzheimer’s dementia and type 2 diabetes: a systematic review and meta-analysis of cohort studies

Publication date :

August 2025

Journal title :

Food Science and Human Wellness

eISSN :

2213-4530

Publisher :

Tsinghua University Press

Volume :

Issue :

Pages :

9250307

Peer reviewed :

Peer Reviewed verified by ORBi

Funding number :

2023B0202080003

Funding text :

This work was supported by the Agricultural Science and Technology Innovation Program, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences under Grant CAAS-ASTIP-2023-IFST, and Guangdong Provincial Key R&D Programme (2023B0202080003). We thank all the people who participated in cohort studies, and the teams who conducted them.

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