Feasibility study of the use of a homemade direct powder extrusion printer to manufacture printed tablets with an immediate release of a BCS II molecule.
Feasibility Study of the Use of a Homemade Direct Powder Extrusion Printer to Manufacture Printed Tablets with an Immediate Release of a BCS II Molecule.pdf
Cannabidiol; Direct powder extrusion; Single-step process; Drug Liberation; Technology, Pharmaceutical/methods; Printing, Three-Dimensional; Technology, Pharmaceutical; Pharmaceutical Science
Abstract :
[en] Among the various 3D printing techniques, FDM is the most studied in pharmaceutical research. However, it requires the fabrication of filaments with suitable mechanical properties using HME, which can be laborious and time-consuming. DPE has emerged as a single-step printing technique that can overcome FDM limits as it enables the direct printing of powder blends without the need of filaments. This study demonstrated the manufacturing of cylindrical-shaped printed tablets containing CBD, a BCS II molecule, with an immediate release. Different blends of PEO/E100 and PEO/SOL, each with 10 % of CBD, were printed and tested according to the Eur. Ph. for uncoated tablets. Each printed cylinder met the Eur. Ph. specifications for friability, mass variation and mass uniformity. However, only the E100-based formulations enabled a CBD immediate release, as formulations containing SOL formed a gel once in contact with the dissolution medium, reducing the drug dissolution rate.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Jennotte, Olivier ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Koch, Nathan ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Lechanteur, Anna ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Rosoux, F; SIRRIS, Collective Centre of the Belgian Technology Industry, 4102 Liege Science Park, Belgium
Emmerechts, C; SIRRIS, Collective Centre of the Belgian Technology Industry, 4102 Liege Science Park, Belgium
Beeckman, E; SIRRIS, Collective Centre of the Belgian Technology Industry, 4102 Liege Science Park, Belgium
Evrard, Brigitte ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Language :
English
Title :
Feasibility study of the use of a homemade direct powder extrusion printer to manufacture printed tablets with an immediate release of a BCS II molecule.
Fonds Léon Fredericq European Regional Development Fund
Funding text :
The authors wish to acknowledge FEDER funds for the support in SOLPHARE FEDER project ( 884148-329407 ) and the Fonds Léon Fredericq for the support in project 2021-2022-12 . The authors also wish to thank Wenda Lazzari and Astrid Couturier (Mithra CDMO) for the loan and the support of the melt pump.
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