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Koch Nathan

Département de pharmacie > Pharmacie galénique

CIRM

See author's contact details
Main Referenced Co-authors
Evrard, Brigitte  (31)
Jennotte, Olivier  (30)
Lechanteur, Anna  (30)
Bourcy, Quentin  (4)
Chiap, Patrice  (4)
Main Referenced Keywords
Solubility enhancement (5); atorvastatin (4); Cannabidiol (4); Hot melt extrusion (4); mesoporous silica (4);
Main Referenced Unit & Research Centers
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège (8)
Center for Education and Research on Macromolecules (CERM) (1)
Centre Interfacultaire de Recherche du Médicament - CIRM (1)
Complex and Entangled Systems from Atoms to Materials (CESAM) Research Unit (1)
Laboratory of Pharmaceutical Technology and Biopharmacy (1)
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (34)
Materials science & engineering (1)
Chemistry (1)

Publications (total 34)

The most downloaded
62 downloads
Jennotte, O., Koch, N., Lechanteur, A., & Evrard, B. (September 2023). Formulation and quality consideration of cannabidiol printed forms produced by fused-deposition modeling. Journal of Drug Delivery Science and Technology, 87, 104837. doi:10.1016/j.jddst.2023.104837 https://hdl.handle.net/2268/306592

The most cited

63 citations (OpenAlex)

Koch, N., Jennotte, O., Gasparrini, Y., Vandenbroucke, F., Lechanteur, A., & Evrard, B. (2020). Cannabidiol aqueous solubility enhancement: comparison of three amorphous formulations strategies using different type of polymers. International Journal of Pharmaceutics. doi:10.1016/j.ijpharm.2020.119812 https://hdl.handle.net/2268/250520

Koch, N., Bourcy, Q., Jennotte, O., Chiap, P., Lechanteur, A., Cardot, J.-M., & Evrard, B. (2025). Selection of In Vivo Relevant Dissolution Test Parameters for the Development of Cannabidiol Formulations with Enhanced Oral Bioavailability. Pharmaceutics. doi:10.3390/pharmaceutics17010079
Peer Reviewed verified by ORBi

Koch, N. (2024). Interest of mesoporous silica to enhance the solubility and the bioavailability of BCS II molecules [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/323224

Koch, N., Jennotte, O., Bourcy, Q., Lechanteur, A., DEVILLE, M., Charlier, C., CHIAP, P., Cardot, J. M., & Evrard, B. (27 April 2024). Evaluation of amorphous and lipid-based formulation strategies to increase the in vivo cannabidiol bioavailability in piglets. International Journal of Pharmaceutics, 657, 124173. doi:10.1016/j.ijpharm.2024.124173
Peer Reviewed verified by ORBi

Koch, N., Jennotte, O., Lechanteur, A., Grignard, B., & Evrard, B. (17 January 2024). Improvement of aqueous solubility of active pharmaceutical ingredients by using mesoporous silica impregnation under pressurized carbon dioxide [Paper presentation]. 1st FRITCO2T Day.
Peer reviewed

Koch, N., Jennotte, O., Lechanteur, A., DEVILLE, M., Charlier, C., Cardot Jean-Michel, CHIAP, P., & Evrard, B. (2024). An Intravenous Pharmacokinetic Study of Cannabidiol Solutions in Piglets through the Application of a Validated Ultra-High-Pressure Liquid Chromatography Coupled to Tandem Mass Spectrometry Method for the Simultaneous Quantification of CBD and Its Carboxylated Metabolite in Plasma. Pharmaceutics. doi:10.3390/pharmaceutics16010140
Peer Reviewed verified by ORBi

Jennotte, O., Koch, N., Lechanteur, A., Rosoux, F., Emmerechts, C., Beeckman, E., & Evrard, B. (05 November 2023). Feasibility study of the use of a homemade direct powder extrusion printer to manufacture printed tablets with an immediate release of a BCS II molecule. International Journal of Pharmaceutics, 646, 123506. doi:10.1016/j.ijpharm.2023.123506
Peer Reviewed verified by ORBi

Jennotte, O., Koch, N., Lechanteur, A., & Evrard, B. (September 2023). Formulation and quality consideration of cannabidiol printed forms produced by fused-deposition modeling. Journal of Drug Delivery Science and Technology, 87, 104837. doi:10.1016/j.jddst.2023.104837
Peer reviewed

Jennotte, O., Lechanteur, A., Koch, N., Evrard, B., Rosoux François, Emmerechts Carl, & Beeckman Eric. (20 March 2023). Formulation and Quality Consideration of Printed Tablets of Cannabidiol Produced by Direct Powder Extrusion [Poster presentation]. 4th European Conference on Pharmaceutics, Marseille, France.

Koch, N., Jennotte, O., Bourcy, Q., Lechanteur, A., Chiap, P., & Evrard, B. (2023). How the choice of dissolution parameters influences the interpretation of dissolution efficiency from two different cannabidiol formulations? [Poster presentation]. 4th European Conference on Pharmaceutics, Marseille, France.

Koch, N., Jennotte, O., Bourcy, Q., Lechanteur, A., & Evrard, B. (2023). How the choice of dissolution parameters influences the interpretation of dissolution efficiency from two different cannabidiol formulations? [Paper presentation]. CIRM day 2023.

Koch, N., Jennotte, O., Toussaint, C., Lechanteur, A., & Evrard, B. (2023). Production challenges of tablets containing lipid excipients: case study using cannabidiol as drug model. International Journal of Pharmaceutics, 122639. doi:10.1016/j.ijpharm.2023.122639
Peer Reviewed verified by ORBi

Jennotte, O., Koch, N., Lechanteur, A., & Evrard, B. (2022). Development of amorphous solid dispersions of cannabidiol: Influence of the carrier, the hot-melt extrusion parameters and the use of a crystallization inhibitor. Journal of Drug Delivery Science and Technology, 103372. doi:10.1016/j.jddst.2022.103372
Peer reviewed

Jennotte, O., Koch, N., Rosoux, F., Emmerechts Carl, Beeckman Eric, Lechanteur, A., & Evrard, B. (30 March 2022). Formulation and Quality Consideration of Cannabidiol Printlets Produced by Fused-Deposition Modeling [Poster presentation]. 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology.

Koch, N., Jennotte, O., Lechanteur, A., & Evrard, B. (March 2022). Cannabidiol tablets with an enhanced bioavailability: Optimal selection of excipients and tableting through Design of Experiments [Poster presentation]. PBP 13th World Meeting, Rotterdam, Netherlands.

Koch, N., Jennotte, O., Lechanteur, A., & Evrard, B. (02 February 2022). Development of cannabidiol lipid-dispersion tablets: excipients selection and tabletability [Paper presentation]. CIRM Day 2022.

Jennotte, O., Koch, N., Lechanteur, A., & Evrard, B. (02 February 2022). Formulation and Quality Consideration of Cannabidiol Printlets Produced by Fused-Deposition Modeling [Paper presentation]. CIRM DAY 2022.

Koch, N., Jennotte, O., Ziemons, E., Boussard, G., Lechanteur, A., & Evrard, B. (2022). Influence of API physico-chemical properties on amorphization capacity of several mesoporous silica loading methods. International Journal of Pharmaceutics. doi:10.1016/j.ijpharm.2021.121372
Peer Reviewed verified by ORBi

Koch, N., Jennotte, O., Lechanteur, A., & Evrard, B. (14 May 2021). Improvement of fenofibrate aqueous solubility by using mesoporous silica impregnation under pressurized carbon dioxide [Poster presentation]. PBP 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology.

Jennotte, O., Koch, N., Lechanteur, A., & Evrard, B. (06 April 2021). Amorphous solid dispersions of cannabidiol with an increase of the aqueous solubility: influence of the carrier, the hot melt extrusion parameters and the use of a crystallization inhibitor [Paper presentation]. The Controlled Release Society BeNeLux&France Early Career Scientists Meeting 2021.

Koch, N., Jennotte, O., Lechanteur, A., & Evrard, B. (06 April 2021). Influence of API physico-chemical properties on amorphization capacity of several mesoporous silica loading methods [Paper presentation]. CRS BNFL ECS Meeting 2021.

Penoy, N., Koch, N., Grignard, B., Evrard, B., & Piel, G. (March 2021). The quality by design strategy to prepare different liposomes formulations by a new supercritical fluid method [Poster presentation]. APGI Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology.
Peer reviewed

Koch, N., Jennotte, O., Grignard, B., Lechanteur, A., & Evrard, B. (01 July 2020). Impregnation of mesoporous silica with poor aqueous soluble molecule using pressurized carbon dioxide: is the solubility in the supercritical and subcritical phase a critical parameter? European Journal of Pharmaceutical Sciences, 150, 105332. doi:10.1016/j.ejps.2020.105332
Peer Reviewed verified by ORBi

Koch, N., Jennotte, O., Gasparrini, Y., Vandenbroucke, F., Lechanteur, A., & Evrard, B. (2020). Cannabidiol aqueous solubility enhancement: comparison of three amorphous formulations strategies using different type of polymers. International Journal of Pharmaceutics. doi:10.1016/j.ijpharm.2020.119812
Peer Reviewed verified by ORBi

Jennotte, O., Koch, N., Lechanteur, A., & Evrard, B. (2020). Three-dimensional printing technology as a promising tool in bioavailability enhancement of poorly water-soluble molecules: a review. International Journal of Pharmaceutics. doi:10.1016/j.ijpharm.2020.119200
Peer Reviewed verified by ORBi

Jennotte, O., Koch, N., Lechanteur, A., & Evrard, B. (11 December 2019). Hot-melt extrusion as a solvent-free technique for the formation of a polymeric amorphous solid dispersion of atorvastatin [Paper presentation]. Second scientific CIRM day, Liège, Belgium.

Koch, N., Jennotte, O., Lechanteur, A., & Evrard, B. (11 December 2019). Improvement of fenofibrate aqueous solubility by using mesoporous silica impregnation under pressurized carbon dioxide [Paper presentation]. 2nd CIRM Day.

Servais, A.-C., Degotte, G., & Koch, N. (19 June 2019). Update on the progresses and development of the Biopharmaceutics/Biopharmaceuticals Unifying Thematic [Paper presentation]. CIRM Seminar.

Jennotte, O., Koch, N., Rocks, N., Lechanteur, A., & Evrard, B. (20 May 2019). Development of new manufacturing processes for amorphous solid dispersions [Paper presentation]. 20th forum of pharmaceutical sciences, Bruxelles, Belgium.

Koch, N., Jennotte, O., Rocks, N., Lechanteur, A., & Evrard, B. (20 May 2019). Mesoporous silica impregnation using supercritical carbon dioxide: is the solubility in the supercritical fluid a critical parameter? [Paper presentation]. 20th Forum of Pharmaceutical Sciences, Bruxelles, Belgium.

Koch, N., Jennotte, O., Rocks, N., Lechanteur, A., & Evrard, B. (26 March 2019). Impregnation of mesoporous silica using supercritical-CO2: is the solubility in the supercritical fluid a critical paramter? [Poster presentation]. 3rd European Conference on Pharmaceutics, Bologne, Italy.

Jennotte, O., Koch, N. (Other coll.), Collard, L. (Other coll.), Lechanteur, A. (Other coll.), & Evrard, B. (Other coll.). (26 March 2019). Hot melt extrusion as a solvent-free technique for the formation of a polymeric amorphous solid dispersion of atorvastatin [Poster presentation]. 3rd European Conference on Pharmaceutics, Bologne, Italy.

Vercheval, C., GILLET, M., Koch, N., HAYETTE, M.-P., FRIPPIAT, F., DAMAS, P., & VAN HEES, T. (2019). Utilisation de la nystatine dans la candidose oropharyngée au CHU de Liège. Journal de Pharmacie de Belgique.
Peer Reviewed verified by ORBi

Jennotte, O., Koch, N., Collard, L., Lechanteur, A., & Evrard, B. (19 December 2018). Hot melt extrusion as a solvent-free technique for the formation of a polymeric amorphous solid dispersion of atorvastatin [Paper presentation]. CIRM Day, Liège, Belgium.

Koch, N., Jennotte, O., Rocks, N., Lechanteur, A., & Evrard, B. (December 2018). Impregnation of mesoporous silica with fenofibrate using supercritical-CO2: is the solubility a critical parameter? [Paper presentation]. 1st CIRM scientific Day, Liège, Belgium.

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