Increase in Blood Eosinophil Count Over Time and Sputum IL8 are Associated with FEV1 Decline in Asthma.

Airway inflammation; Asthma; Decline; Eosinophils; Lung Diseases; Interleukin-8; CXCL8 protein, human; Biomarkers; Immunoglobulin E; Interleukin-5; Humans; Male; Female; Middle Aged; Forced Expiratory Volume; Adult; Leukocyte Count; Time Factors; Disease Progression; Lung/physiopathology; Immunoglobulin E/blood; Interleukin-5/blood; Sputum/immunology; Asthma/physiopathology; Asthma/blood; Asthma/immunology; Asthma/diagnosis; Interleukin-8/blood; Biomarkers/blood

Abstract :

[en] [en] BACKGROUND: Asthma is associated with accelerated rate of FEV1 decline. OBJECTIVE: To determine predictive factors associated with accelerated FEV1 decline in adult asthma and evaluate sputum cytokines as potential biomarkers for airflow decline. METHODS: We recruited 125 asthmatics evaluated at the asthma clinic of Liège and reevaluated them at least 5 years later. Clinical, functional and inflammatory characteristics were compared between patients with accelerated decline (FEV1 decline > 0.85% pred.y-1) and others. Predictive factors were highlighted with linear regression analysis. Sputum EGF, VEGF, FGF, IL5, IL8, TGF-β, and IgE levels were measured in 58 of these patients at both visits by Human XL cytokine Luminex Performance assay and Elisa. RESULTS: Post-BD FEV1 decline was 0.06 ± 2.44% pred.y-1 in the overall population. Median (IQR) time between visits was 66 (62 - 86) months. The multivariable analysis showed that an increase in blood eosinophils over time (Δ BEC) (Reg. Coef. (95%CI): 0.002 (0.001 to 0.004), p = 0.005)) and onset of asthma (0.04 (0.003 to 0.07), p = 0.036) were independently associated with FEV1 decline. IL8 levels measured at baseline were higher (499 (408-603) pg/ml, p = 0.0040) in patients with accelerated decline compared to others (143 (88-308) pg/ml). CONCLUSION: In this study, we have confirmed that an increase in blood eosinophil counts over a follow-up of at least 5 years and later onset of asthma are associated with accelerated annual FEV1 decline. Moreover, high sputum IL8 levels could be a risk factor for accelerated decline in asthma patients.

Disciplines :

Cardiovascular & respiratory systems

Author, co-author :

Graff, Sophie ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Médecine vétérinaire comparée

Moermans, Catherine ; Université de Liège - ULiège > GIGA > GIGA I3 - Pneumology

Gerday, Sara ; Université de Liège - ULiège > Faculté de Médecine > Form. doct. sc. méd. (paysage)

Henket, Monique ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie

PAULUS, Virginie ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie

GUISSARD, Françoise ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie

Louis, Renaud ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie

Schleich, Florence ; Université de Liège - ULiège > GIGA > GIGA I3 - Pneumology

Language :

English

Title :

Increase in Blood Eosinophil Count Over Time and Sputum IL8 are Associated with FEV1 Decline in Asthma.

Publication date :

30 November 2024

Journal title :

Lung

ISSN :

0341-2040

eISSN :

1432-1750

Publisher :

Springer Science and Business Media LLC, United States

Volume :

203

Issue :

Pages :

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://link.springer.com/content/pdf/10.1007/s00408-024-00760-9.pdf

Available on ORBi :

since 02 January 2025

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Bibliography

P. Lange J. Parner J. Vestbo P. Schnohr G. Jensen A 15-year follow-up study of ventilatory function in adults with asthma N Engl J Med 1998 339 1194 1200 10.1056/NEJM199810223391703 9780339
M. Contoli S. Baraldo B. Marku P. Casolari J.A. Marwick G. Turato M. Romagnoli G. Caramori M. Saetta L.M. Fabbri A. Papi Fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease: 5-year follow-up J Allergy Clin Immunol 2010 125 830 837 10.1016/j.jaci.2010.01.003 20227753
M. Broekema F. Volbeda W. Timens A. Dijkstra N.A. Lee J.J. Lee M.E. Lodewijk D.S. Postma M.N. Hylkema N.H.T. ten Hacken Airway eosinophilia in remission and progression of asthma: accumulation with a fast decline of FEV(1) Respir Med 2010 104 1254 1262 10.1016/j.rmed.2010.03.030 20434897
D. Talini F. Novelli E. Bacci M. Bartoli S. Cianchetti F. Costa F.L. Dente A. Di Franco M. Latorre L. Malagrino B. Vagaggini A. Celi P. Paggiaro Sputum eosinophilia is a determinant of FEV1 decline in occupational asthma: results of an observational study BMJ Open 2015 5 e005748 e005748 10.1136/bmjopen-2014-005748 25564139 4289723
Sposato B, Scalese M, Ricci A, Rogliani P, Paggiaro P, The Omalizumab Italian Study Group, Sposato B, Migliorini MG, Di Tomassi M, Olivieri C, Perrella A, Camiciottoli G, Maselli R, Pelaia G, Busceti MT, Sabato E, Cagnazzo MG, Colombo F, Palumbo L, Ravazzi A, Bucca C, Caiaffa MF, Berra A, Calabrese C, Stanziola AA, Schino P, Di Gioacchino M, Rogliani P, Cazzola M, Segreti A, Pastorello EA, Scibilia G, Vianello A, Marchi MR, Paladini L, Baglioni S, Abbritti M, Almerigogna F, Matucci A, Vultaggio A, Maggi E, Maestrelli P, Guarnieri G, Steinhilber G, Bonavia M, Rottoli P, Bargagli E, Senna G, Caminati M, Macchia L, Bellia V, Scichilone N, Paggiaro P, Novelli F, Latorre M, Vergura L, Masieri S, Scalese M, Rosati Y, Milanese M, Folletti I, Pio R, Pio A, Maccari U, Maggiorelli C, Scala R, Vignale L, Pulerà N, Carpagnano GE, Foschino Barbaro MP (2021) Persistence of both reversible airway obstruction and higher blood eosinophils may predict lung function decline in severe asthma. Clin Respir J 15:237–243. https://doi.org/10.1111/crj.13325
C. Newby J. Agbetile B. Hargadon W. Monteiro R. Green I. Pavord C. Brightling S. Siddiqui Lung function decline and variable airway inflammatory pattern: longitudinal analysis of severe asthma J Allergy Clin Immunol 2014 134 287 294 10.1016/j.jaci.2014.04.005 24928647
Graff S, Demarche S, Henket M, Paulus V, Louis R, Schleich F (2019) Increase in blood eosinophils during follow-up is associated with lung function decline in adult asthma. Respir Med 152:60–66
S. Cianchetti C. Cardini I. Puxeddu M. Latorre M.L. Bartoli M. Bradicich F. Dente E. Bacci A. Celi P. Paggiaro Distinct profile of inflammatory and remodelling biomarkers in sputum of severe asthmatic patients with or without persistent airway obstruction World Allergy Organ J 2019 12 10.1016/j.waojou.2019.100078 31871533 6911957
F.N. Schleich D. Zanella P.-H. Stefanuto K. Bessonov A. Smolinska J.W. Dallinga M. Henket V. Paulus F. Guissard S. Graff C. Moermans E.F.M. Wouters K. Van Steen F.-J. van Schooten J.-F. Focant R. Louis Exhaled volatile organic compounds are able to discriminate between neutrophilic and eosinophilic asthma Am J Respir Crit Care Med 2019 200 444 453 10.1164/rccm.201811-2210OC 30973757
GINA-Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2018. Available from: www.ginasthma.org
E.F. Juniper G.H. Guyatt R.S. Epstein P.J. Ferrie R. Jaeschke T.K. Hiller Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials Thorax 1992 47 2 76 83 10.1136/thx.47.2.76 1549827 463574
E.F. Juniper P.M. O’Byrne G.H. Guyatt P.J. Ferrie D.R. King Development and validation of a questionnaire to measure asthma control Eur Respir J 1999 14 902 907 10.1034/j.1399-3003.1999.14d29.x 10573240
R.A. Nathan M. Kosinski T.B. Pendergraft P. Jhingran Asthma control test: reliability, validity, and responsiveness in patients not previously followed by asthma specialists J Allergy Clin Immunol 2006 117 549 556 10.1016/j.jaci.2006.01.011 16522452
R.A. Dweik P.B. Boggs S.C. Erzurum C.G. Irvin M.W. Leigh J.O. Lundberg A.C. Olin A.L. Plummer D.R. Taylor American thoracic society committee on interpretation of exhaled nitric oxide levels (FENO) for clinical applications an official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications Am J Respir Crit Care Med 2011 184 5 602 615 10.1164/rccm.9120-11ST 21885636 4408724
J. Guiot S. Demarche M. Henket V. Paulus S. Graff F. Schleich J.-L. Corhay R. Louis C. Moermans Methodology for sputum induction and laboratory processing J Vis Exp JoVE 2017 10.3791/56612 29286433
M. Delvaux M. Henket L. Lau P. Kange P. Bartsch R. Djukanovic R. Louis Nebulised salbutamol administered during sputum induction improves bronchoprotection in patients with asthma Thorax 2004 59 111 115 10.1136/thorax.2003.011130 14760148 1746927
P.H. Quanjer S. Stanojevic T.J. Cole X. Baur G.L. Hall B.H. Culver P.L. Enright J.L. Hankinson M.S. Ip J. Zheng J. Stocks ERS global lung function initiative. Multi-ethnic reference values for spirometry for the 3–95-yr age range: the global lung function 2012 equations Eur Respir J 2012 40 6 1324 1343 10.1183/09031936.00080312 22743675 3786581
L. Godinas J.-L. Corhay M. Henket J. Guiot R. Louis C. Moermans Increased production of TGF-β1 from sputum cells of COPD: relationship with airway obstruction Cytokine 2017 99 1 8 10.1016/j.cyto.2017.06.018 28668545
S. Graff N. Bricmont C. Moermans M. Henket V. Paulus F. Guissard R. Louis F. Schleich Clinical and biological factors associated with irreversible airway obstruction in adult asthma Respir Med 2020 175 10.1016/j.rmed.2020.106202 33202369
J.L. Schafer J.W. Graham Missing data: our view of the state of the art Psychol Methods 2002 7 147 177 10.1037/1082-989X.7.2.147 12090408
Multiple Imputation for Nonresponse in Surveys | Wiley. In: Wiley.com. https://www.wiley.com/en-us/Multiple+Imputation+for+Nonresponse+in+Surveys-p-9780471655749. Accessed 10 Feb 2021
W.W. Busse S. Pedersen R.A. Pauwels W.C. Tan Y.-Z. Chen C.J. Lamm P.M. O’Byrne START Investigators Group The inhaled steroid treatment as regular therapy in early asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma J Allergy Clin Immunol 2008 121 1167 1174 10.1016/j.jaci.2008.02.029 18405951
H. Backman A. Lindberg L. Hedman C. Stridsman S.-A. Jansson T. Sandström B. Lundbäck E. Rönmark FEV1 decline in relation to blood eosinophils and neutrophils in a population-based asthma cohort World Allergy Organ J 2020 13 10.1016/j.waojou.2020.100110 32206161 7082214
A.T. Hastie D.T. Mauger L.C. Denlinger A. Coverstone M. Castro S. Erzurum N. Jarjour B.D. Levy D.A. Meyers W.C. Moore B.R. Phillips S.E. Wenzel J.V. Fahy E. Israel E.R. Bleecker Mixed sputum granulocyte longitudinal impact on lung function in the severe asthma research program Am J Respir Crit Care Med 2021 203 882 892 10.1164/rccm.202009-3713OC 33545021 8017570
B. Sposato Predicted values for spirometry may underestimate long-standing asthma severity Open Respir Med J 2016 10 70 78 10.2174/1874306401610010070 28144365 5220173
L.C. Denlinger B.R. Phillips R.L. Sorkness E.R. Bleecker M. Castro M.D. DeBoer A.M. Fitzpatrick A.T. Hastie J.M. Gaffin W.C. Moore M.C. Peters S.P. Peters W. Phipatanakul J.C. Cardet S.C. Erzurum J.V. Fahy M.L. Fajt B. Gaston B.D. Levy D.A. Meyers K. Ross W.G. Teague S.E. Wenzel P.G. Woodruff J. Zein N.N. Jarjour D.T. Mauger E. Israel Responsiveness to parenteral corticosteroids and lung function trajectory in adults with moderate-to-severe asthma Am J Respir Crit Care Med 2021 203 841 852 10.1164/rccm.202002-0454OC 33290668 8017577
F. Schleich S. Graff H. Nekoee C. Moermans M. Henket C. Sanchez V. Paulus F. Guissard A. Donneau R. Louis Real-word experience with mepolizumab: does it deliver what it has promised? Clin Exp Allergy 2020 50 687 695 10.1111/cea.13601 32198794
F. Schleich R. Louis It needs more than just eosinophils to cause emphysema in COPD Eur Respir J 2019 10.1183/13993003.00332-2019 31467116
A.D. Doyle M. Mukherjee W.E. LeSuer T.B. Bittner S.M. Pasha J.J. Frere J.L. Neely J.A. Kloeber K.P. Shim S.I. Ochkur T. Ho S. Svenningsen B.L. Wright M.A. Rank J.J. Lee P. Nair E.A. Jacobsen Eosinophil-derived IL-13 promotes emphysema Eur Respir J 2019 53 1801291 10.1183/13993003.01291-2018 30728205 7313423
C. Cabrera López A. Sánchez Santos A. Lemes Castellano S. Cazorla Rivero J. Breña Atienza E. González Dávila B. Celli M.C. Casanova Eosinophil subtypes in adults with asthma and adults with chronic obstructive pulmonary disease Am J Respir Crit Care Med 2023 10.1164/rccm.202301-0149OC 37071848
C. Mesnil S. Raulier G. Paulissen X. Xiao M.A. Birrell D. Pirottin T. Janss P. Starkl E. Ramery M. Henket F.N. Schleich M. Radermecker K. Thielemans L. Gillet M. Thiry M.G. Belvisi R. Louis C. Desmet T. Marichal F. Bureau Lung-resident eosinophils represent a distinct regulatory eosinophil subset J Clin Invest 2016 126 3279 3295 10.1172/JCI85664 27548519 5004964
C.S. Ulrik P. Lange Decline of lung function in adults with bronchial asthma Am J Respir Crit Care Med 1994 150 629 634 10.1164/ajrccm.150.3.8087330 8087330
C. Porsbjerg P. Lange C.S. Ulrik Lung function impairment increases with age of diagnosis in adult onset asthma Respir Med 2015 109 821 827 10.1016/j.rmed.2015.04.012 25962648
F. Schleich G. Brusselle R. Louis O. Vandenplas A. Michils C. Pilette R. Peche M. Manise G. Joos Heterogeneity of phenotypes in severe asthmatics. the belgian severe asthma registry (BSAR) Respir Med 2014 108 1723 1732 10.1016/j.rmed.2014.10.007 25456708
F.N. Schleich A. Chevremont V. Paulus M. Henket M. Manise L. Seidel R. Louis Importance of concomitant local and systemic eosinophilia in uncontrolled asthma Eur Respir J 2014 44 97 108 10.1183/09031936.00201813 24525441
A.-X. Huang L.-W. Lu W.-J. Liu M. Huang Plasma inflammatory cytokine IL-4, IL-8, IL-10, and TNF-α levels correlate with pulmonary function in patients with asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome Med Sci Monit 2016 22 2800 2808 10.12659/MSM.896458 27501772 4982526
T.M.A. Wilkinson I.S. Patel M. Wilks G.C. Donaldson J.A. Wedzicha Airway bacterial load and FEV 1 decline in patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med 2003 167 1090 1095 10.1164/rccm.200210-1179OC 12684248
M. Marc-Malovrh L. Camlek S. Škrgat I. Kern M. Fležar M. Dežman P. Korošec Elevated eosinophils, IL5 and IL8 in induced sputum in asthma patients with accelerated FEV1 decline Respir Med 2020 162 10.1016/j.rmed.2020.105875 32056673
P.-L. Kuo Y.-L. Hsu M.-S. Huang S.-L. Chiang Y.-C. Ko Bronchial epithelium-derived IL-8 and RANTES increased bronchial smooth muscle cell migration and proliferation by Krüppel-like factor 5 in areca nut-mediated airway remodeling Toxicol Sci 2011 121 177 190 10.1093/toxsci/kfr030 21297082
K. Hosoki S. Ying C. Corrigan H. Qi A. Kurosky K. Jennings Q. Sun I. Boldogh S. Sur Analysis of a panel of 48 cytokines in BAL fluids specifically identifies IL-8 levels as the only cytokine that distinguishes controlled asthma from uncontrolled asthma, and correlates inversely with FEV1 PLoS ONE 2015 10.1371/journal.pone.0126035 26011707 4444276
P.G. Gibson J.L. Simpson N. Saltos Heterogeneity of airway inflammation in persistent asthma: evidence of neutrophilic inflammation and increased sputum interleukin-8 Chest 2001 119 1329 1336 10.1378/chest.119.5.1329 11348936
R.A. Thomas R.H. Green C.E. Brightling S.S. Birring D. Parker A.J. Wardlaw I.D. Pavord The influence of age on induced sputum differential cell counts in normal subjects Chest 2004 126 1811 1814 10.1378/chest.126.6.1811 15596678
M.-E. Ducharme P. Prince N. Hassan P. Nair L.-P. Boulet Expiratory flows and airway inflammation in elderly asthmatic patients Respir Med 2011 105 1284 1289 10.1016/j.rmed.2011.04.006 21546232
F. Schleich S. Graff F. Guissard M. Henket V. Paulus R. Louis Asthma in elderly is characterized by increased sputum neutrophils, lower airway caliber variability and air trapping Respir Res 2021 22 15 10.1186/s12931-021-01619-w 33441106 7805110
F.N. Schleich M. Manise J. Sele M. Henket L. Seidel R. Louis Distribution of sputum cellular phenotype in a large asthma cohort: predicting factors for eosinophilic vs neutrophilic inflammation BMC Pulm Med 2013 13 11 10.1186/1471-2466-13-11 23442497 3657295
P.M. O’Byrne H. Metev M. Puu K. Richter C. Keen M. Uddin B. Larsson M. Cullberg P. Nair Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial Lancet Respir Med 2016 4 797 806 10.1016/S2213-2600(16)30227-2 27574788

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