Chemical composition, angiotensin I-converting enzyme inhibitory, antioxidant and antimicrobial activities of essential oil of Tunisian Thymus algeriensis Boiss. et Reut. (Lamiaceae)

Zouari, Nacim; Fakhfakh, Nahed; Zouari, Sami; Bougatef, Ali; Karray, Aida; Neffati, Mohamed; Ayadi, Mohamed

doi:10.1016/j.fbp.2010.11.006

Article (Scientific journals)

Chemical composition, angiotensin I-converting enzyme inhibitory, antioxidant and antimicrobial activities of essential oil of Tunisian Thymus algeriensis Boiss. et Reut. (Lamiaceae)

Zouari, Nacim; Fakhfakh, Nahed; Zouari, Sami et al.

2011 • In Food and Bioproducts Processing, 89 (4), p. 257 - 265

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/325422

DOI
10.1016/j.fbp.2010.11.006

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Keywords :

Angiotensin I-converting enzyme; Antimicrobial activity; Antioxidant activity; Chemical composition; Essential oil; Thymus algeriensis

Abstract :

[en] The present study describes chemical composition, angiotensin I-converting enzyme (ACE) inhibitory, antioxidant and antimicrobial activities of the essential oil of wild growing Thymus algeriensis Boiss. et Reut. (Lamiaceae), a traditional medicinal plant which is mainly endemic in Tunisia and Algeria. The essential oil from the fresh leaves and flowers of T. algeriensis were extracted by hydrodistillation and analysed by GC and GC/MS. Fifty-seven compounds were identified accounting for 97.71% of the total oil, where oxygenated monoterpenes constituted the main chemical class (44.85%). The oil was dominated by camphor (7.82%), 4-terpineol (7.36%), α-pinene (6.75%), 1,8-cineole (5.54%) and cis-sabinene hydrate (5.29%). The T. algeriensis essential oil was found to possess an interesting inhibitory activity towards ACE with an IC50 value of 150 μg/ml. The obtained results also showed that this oil can act as radical scavengers (IC50 = 0.8 mg/ml) and displayed a lipid peroxidation inhibitory activity (IC50 = 0.5 mg/ml) as evaluated by 2,2-diphenyl-1-picrylhydrazyl and β-carotene bleaching methods, respectively. Furthermore, the oil was tested for antimicrobial activity against six bacterial strains and two fungal strains. The inhibition zones and minimal inhibitory concentration values of microbial strains were in the range of 13.5-64 mm and 1-6 μl/ml, respectively. The oil exhibited remarkable inhibitory activity against fungal and Gram-positive bacteria strains. © 2010 The Institution of Chemical Engineers.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Zouari, Nacim; Laboratoire de Biochimie et de Génie Enzymatique des Lipases, Ecole Nationale d'Ingénieurs de Sfax (ENIS), 3038 Sfax, Tunisia ; Institut Supérieur de Biologie Appliquée de Médenine, 4119 Médenine, Tunisia

Fakhfakh, Nahed; Laboratoire de Génie Enzymatique et de Microbiologie, ENIS, 3038 Sfax, Tunisia

Zouari, Sami; Laboratoire d'Ecologie Pastorale, Institut des Régions Arides, 4119 Médenine, Tunisia

Bougatef, Ali; Laboratoire de Génie Enzymatique et de Microbiologie, ENIS, 3038 Sfax, Tunisia

Karray, Aida; Laboratoire de Biochimie et de Génie Enzymatique des Lipases, Ecole Nationale d'Ingénieurs de Sfax (ENIS), 3038 Sfax, Tunisia

Neffati, Mohamed; Laboratoire d'Ecologie Pastorale, Institut des Régions Arides, 4119 Médenine, Tunisia

Ayadi, Mohamed ; Laboratoire d'Analyse Alimentaire, ENIS, 3038 Sfax, Tunisia

Language :

English

Title :

Chemical composition, angiotensin I-converting enzyme inhibitory, antioxidant and antimicrobial activities of essential oil of Tunisian Thymus algeriensis Boiss. et Reut. (Lamiaceae)

Publication date :

October 2011

Journal title :

Food and Bioproducts Processing

ISSN :

0960-3085

eISSN :

1744-3571

Publisher :

Elsevier

Volume :

Issue :

Pages :

257 - 265

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0960308510001185?httpAccept=text/xml

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