Highlights in gynaecological cancers

In the field of gynaecologic oncology, numerous studies were presented at the 2024 ASCO Annual Meeting. Several therapeutic de-escalation strategies were discussed, including the lack of benefits from lymphadenectomy in advanced ovarian cancer and from adjuvant chemotherapy in early high-risk cervical cancer. Neoadjuvant combined with adjuvant PARP inhibitors for patients with resectable recurrent ovarian tumours
is a promising approach to avoid chemotherapy and enhance quality of life. Among the new treatments, mirvetuximab soravtansine for platinum-resistant ovarian cancers and selinexor for advanced or recurrent TP53 wild-type endometrial tumours are particularly promising. Additionally, several trials have explored the impact of obesity and its management in gynaecological cancers.