A Zebrafish Embryo Model to Screen Potential Therapeutic Compounds in Sapindaceae Poisoning

Myopathie atypique; Atypical myopathy; Toxine; Toxin; Intoxication; Poisoning; Pharmacology; Pharmacologie; Traitement; Treatment; Toxicologie; Toxicology; Modèle; Model; Muscle; Zebrafish larvae; Zebrabox; Poissons-zèbres

Abstract :

[en] Hypoglycin A (HGA) and methylenecyclopropylglycine (MCPrG) are protoxins produced by Sapindaceae plants, particularly Acer pseudoplatanus, and are responsible for causing atypical myopathy (AM) in equids. These protoxins metabolise into toxic compounds, such as methylenecyclopropylacetyl-CoA (MCPA-CoA), which alters energy metabolism and induces severe rhabdomyolysis. Currently, no specific treatment exists for this poisoning, in vitro models fail to reproduce HGA’s toxic effects on equine primary myoblasts, and mammalian models are impractical for large-scale drug screening. This study aimed to develop a zebrafish embryo model for screening therapeutic compounds against AM.

Research Center/Unit :

FARAH - Fundamental and Applied Research for Animals and Health - ULiège
FARAH. Médecine vétérinaire comparée - ULiège

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Wouters, Clovis ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Médecine vétérinaire comparée

Klein, Benjamin ; Université de Liège - ULiège > Département des sciences fonctionnelles (DSF)

Price, Nicholas; Department of Biochemistry, University of Alberta, Edmonton, Canada

Boemer, François ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Voz, Marianne ; Université de Liège - ULiège > GIGA > GIGA Stem Cells - Zebrafish Development and Disease Model

Votion, Dominique ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Médecine vétérinaire comparée

Language :

English

Title :

A Zebrafish Embryo Model to Screen Potential Therapeutic Compounds in Sapindaceae Poisoning

Alternative titles :

[fr] Un modèle d'embryon de poisson zèbre pour cribler les composés thérapeutiques potentiels dans l'empoisonnement par les sapindacées

Publication date :

19 October 2024

Journal title :

Molecules

eISSN :

1420-3049

Publisher :

Multidisciplinary Digital Publishing Institute (MDPI), Switzerland

Special issue title :

Veterinary Drugs—2nd Edition

Volume :

Pages :

1-17

Peer reviewed :

Peer Reviewed verified by ORBi

Development Goals :

15. Life on land

Additional URL :

https://www.mdpi.com/1420-3049/29/20/4954#app1-molecules-29-04954

Name of the research project :

SAMA

Funders :

SPW DG03-DGARNE - Service Public de Wallonie. Direction Générale Opérationnelle Agriculture, Ressources naturelles et Environnement

Funding number :

D65-1418

Available on ORBi :

since 21 October 2024

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