Frosali S, Pagliari D, Gambassi G, Landolfi R, Pandolfi F, Cianci R. How the intricate interaction among toll-like receptors, microbiota, and intestinal immunity can influence gastrointestinal pathology. J Immunol Res. 2015;2015:1-12.
Pagliari D, Saviano A, Newton EE, et al. Gut microbiota-immune system crosstalk and pancreatic disorders. Mediators Inflamm. 2018;2018:1-13.
Pagliari D, Piccirillo CA, Larbi A, Cianci R. The interactions between innate immunity and microbiota in gastrointestinal diseases. Hindawi. 2015;2015:1-3.
Longman RS, Yang Y, Diehl GE, Kim SV, Littman DR. Microbiota: host interactions in mucosal homeostasis and systemic autoimmunity. Cold Spring Harbor Symposia on Quantitative Biology. Vol 78. Cold Spring Harbor Laboratory Press; 2013:193-201.
Macpherson AJ, Geuking MB, McCoy KD. Innate and adaptive immunity in host-microbiota mutualism. Front Biosci (Schol Ed). 2012;4:685-698.
Drago L, Valentina C, Fabio P. Gut microbiota, dysbiosis and colon lavage. Dig Liver Dis. 2019;51(9):1209-1213.
Arthur JC, Perez-Chanona E, Mühlbauer M, et al. Intestinal inflammation targets cancer-inducing activity of the microbiota. Science. 2012;338(6103):120-123.
Holmes E, Li JV, Marchesi JR, Nicholson JK. Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk. Cell Metab. 2012;16(5):559-564.
Lin L, Zhang J. Role of intestinal microbiota and metabolites on gut homeostasis and human diseases. BMC Immunol. 2017;18(1):1-25.
Mima K, Nakagawa S, Sawayama H, et al. The microbiome and hepatobiliary-pancreatic cancers. Cancer Lett. 2017;402:9-15.
Garrett WS. Cancer and the microbiota. Science. 2015;348(6230):80-86.
García-Castillo V, Sanhueza E, McNerney E, Onate SA, García A. Microbiota dysbiosis: a new piece in the understanding of the carcinogenesis puzzle. J Med Microbiol. 2016;65(12):1347-1362.
Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140(6):883-899.
Cianci R, Pagliari D, Pietroni V, Landolfi R, Pandolfi F. Tissue infiltrating lymphocytes: the role of cytokines in their growth and differentiation. J Biol Regulat Homeostatic Agents. 2010;24(3):239-249.
Pandolfi F, Cianci R, Pagliari D, et al. The immune response to tumors as a tool toward immunotherapy. Clin Develop Immunol. 2011;2011:1-12.
Yoon H-Y, Kim H-N, Lee SH, et al. The relationship between platelet count and host gut microbiota: a population-based retrospective cross-sectional study. J Clin Med. 2019;8(2):230.
Schluter J, Peled JU, Taylor BP, et al. The gut microbiota is associated with immune cell dynamics in humans. Nature. 2020;588(7837):303-307.
Zou W. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer. 2005;5(4):263-274.
Templeton AJ, McNamara MG, Šeruga B, et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Nat Cancer Inst. 2014;106(6):1-11.
Fest J, Ruiter R, Mulder M, et al. The systemic immune-inflammation index is associated with an increased risk of incident cancer—a population-based cohort study. Int J Cancer. 2020;146(3):692-698.
Iwasaki A, Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science. 2010;327(5963):291-295.
Hu B, Yang X-R, Xu Y, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014;20(23):6212-6222.
Li Y, Wang B, Zhou S, et al. Do routine blood test results help in the diagnosis of spine tumors? A retrospective study of the significance of pretreatment neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios from 503 spine tumor patients. Medicine. 2019;98(15):e14902.
Zhong A, Cheng C-S, Kai J, Lu R, Guo L. Clinical significance of glucose to lymphocyte ratio (GLR) as a prognostic marker for patients with pancreatic cancer. Front Oncol. 2020;10:520330.
Ikram MA, Brusselle GGO, Murad SD, et al. The Rotterdam Study: 2018 update on objectives, design and main results. Eur J Epidemiol. 2017;32(9):807-850.
Ikram MA, Brusselle G, Ghanbari M, et al. Objectives, design and main findings until 2020 from the Rotterdam study. Eur J Epidemiol. 2020;35:483-517.
Hofman A, Grobbee DE, De Jong P, Van den Ouweland FA. Determinants of disease and disability in the elderly: the Rotterdam elderly study. Eur J Epidemiol. 1991;7(4):403-422.
Radjabzadeh D, Boer CG, Beth SA, et al. Diversity, compositional and functional differences between gut microbiota of children and adults. Sci Rep. 2020;10(1):1-13.
Schmieder R, Lim YW, Rohwer F, Edwards R. TagCleaner: identification and removal of tag sequences from genomic and metagenomic datasets. BMC Bioinformat. 2010;11(1):1-14.
Callahan BJ, McMurdie PJ, Rosen MJ, Han AW, Johnson AJA, Holmes SP. DADA2: high-resolution sample inference from Illumina amplicon data. Nat Methods. 2016;13(7):581-583.
Wang Q, Garrity GM, Tiedje JM, Cole JR. Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl Environ Microbiol. 2007;73(16):5261-5267.
Quast C, Pruesse E, Yilmaz P, et al. The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Nucleic Acids Res. 2012;41(D1):D590-D596.
McMurdie PJ, Holmes S. Phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. PloS One. 2013;8(4):e61217.
Schliep KP. phangorn: phylogenetic analysis in R. Bioinformatics. 2011;27(4):592-593.
Tai W, He L, Zhang X, et al. Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine. Cell Mol Immunol. 2020;17(6):613-620.
Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B Methodol. 1995;57:289-300.
Mahajan P, Kulkarni A, Bandre A, Subramanian S, Mahajan S. Role of gut microbiota in autoimmune diseases: a review. J Vaccines Immunol. 2021;6(163):1-14.
Al-Ishaq RK, Koklesova L, Kubatka P, Büsselberg D. Immunomodulation by gut microbiome on gastrointestinal cancers: focusing on colorectal cancer. Cancer. 2022;14(9):2140.
Chauhan R, Trivedi V. Inflammatory markers in cancer: potential resources. Front Biosci Scholar. 2020;12(1):1-24.
Sridharan DM, Asaithamby A, Blattnig SR, et al. Evaluating biomarkers to model cancer risk post cosmic ray exposure. Life Sci Space Res. 2016;9:19-47.
Zhao L, Cho WC, Nicolls MR. Colorectal cancer-associated microbiome patterns and signatures. Front Genet. 2021;12:2687.
Jia W, Rajani C, Xu H, Zheng X. Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma. Protein Cell. 2021;12(5):374-393.
Komiyama S, Yamada T, Takemura N, Kokudo N, Hase K, Kawamura YI. Profiling of tumour-associated microbiota in human hepatocellular carcinoma. Sci Rep. 2021;11(1):1-9.
Huang X, Li C, Li F, Zhao J, Wan X, Wang K. Cervicovaginal microbiota composition correlates with the acquisition of high-risk human papillomavirus types. Int J Cancer. 2018;143(3):621-634.
Coker OO, Dai Z, Nie Y, et al. Mucosal microbiome dysbiosis in gastric carcinogenesis. Gut. 2018;67(6):1024-1032.
Samuelson DR, Welsh DA, Shellito JE. Regulation of lung immunity and host defense by the intestinal microbiota. Front Microbiol. 2015;6:1085.
Cheng WY, Wu C-Y, Yu J. The role of gut microbiota in cancer treatment: friend or foe? Gut. 2020;69(10):1867-1876.
Wang T, Cai G, Qiu Y, et al. Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers. ISME J. 2012;6(2):320-329.
Li L, Li X, Zhong W, et al. Gut microbiota from colorectal cancer patients enhances the progression of intestinal adenoma in Apcmin/+ mice. EBioMedicine. 2019;48:301-315.
Cheng WT, Kantilal HK, Davamani F. The mechanism of Bacteroides fragilis toxin contributes to colon cancer formation. Malaysian J Med Sci. 2020;27(4):9-21.
Neu J. The early microbiome and subsequent obesity. The microbiome in prenatal and neonatal life. Academic Press; 2021;137-143.
Koliada A, Syzenko G, Moseiko V, et al. Association between body mass index and Firmicutes/Bacteroidetes ratio in an adult Ukrainian population. BMC Microbiol. 2017;17(1):1-6.
Morgan XC, Tickle TL, Sokol H, et al. Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol. 2012;13(9):1-18.
Zhang M, Zhou H, Xu S, et al. The gut microbiome can be used to predict the gastrointestinal response and efficacy of lung cancer patients undergoing chemotherapy. Ann Palliat Med. 2020;9(6):4211-4227.
Ming L, Fang Y, Xiaohui C, et al. Alteration of gut microbiome in lung cancer patients. bioRxiv, 2019, 640359.
Bello S, Vengoechea JJ, Ponce-Alonso M, et al. Core microbiota in central lung cancer with streptococcal enrichment as a possible diagnostic marker. Arch Bronconeumol. 2021;57(11):681-689.
Barka EA, Vatsa P, Sanchez L, et al. Taxonomy, physiology, and natural products of Actinobacteria. Microbiol Mol Biol Rev. 2016;80(1):1-43.
Binda C, Lopetuso LR, Rizzatti G, Gibiino G, Cennamo V, Gasbarrini A. Actinobacteria: a relevant minority for the maintenance of gut homeostasis. Dig Liver Dis. 2018;50(5):421-428.
Yang R, Chang Q, Meng X, Gao N, Wang W. Prognostic value of systemic immune-inflammation index in cancer: a meta-analysis. J Cancer. 2018;9(18):3295-3302.
Zhao QT, Yuan Z, Zhang H, et al. Prognostic role of platelet to lymphocyte ratio in non-small cell lung cancers: a meta-analysis including 3,720 patients. Int J Cancer. 2016;139(1):164-170.
Nøst TH, Alcala K, Urbarova I, et al. Systemic inflammation markers and cancer incidence in the UK biobank. Eur J Epidemiol. 2021;36(8):841-848.
Tian T, Lu J, Zhao W, et al. Associations of systemic inflammation markers with identification of pulmonary nodule and incident lung cancer in Chinese population. Cancer Med. 2022;11:2482-2491.
Wong JYY, Bassig BA, Loftfield E, et al. White blood cell count and risk of incident lung cancer in the UK biobank. JNCI Cancer Spectrum. 2020;4(2):pkz102.
Lee Y-J, Lee H-R, Nam C-M, Hwang U-K, Jee S-H. White blood cell count and the risk of colon cancer. Yonsei Med J. 2006;47(5):646-656.
Giannakeas V, Kotsopoulos J, Cheung MC, et al. Analysis of platelet count and new cancer diagnosis over a 10-year period. JAMA Netw Open. 2022;5(1):e2141633-e.
