Article (Scientific journals)
Unraveling the Dynamics of Estrogen and Progesterone Signaling in the Endometrium: An Overview
Dias Da Silva, Isabelle; Wuidar, Vincent; Zielonka, Manon et al.
2024In Cells, 13
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Keywords :
endometrium; estrogen receptor; progesterone receptor; progestogen; signaling pathway; transcription factor
Abstract :
[en] The endometrium is crucial for the perpetuation of human species. It is a complex and dynamic tissue lining the inner wall of the uterus, regulated throughout a woman's life based on estrogen and progesterone fluctuations. During each menstrual cycle, this multicellular tissue undergoes cyclical changes, including regeneration, differentiation in order to allow egg implantation and embryo development, or shedding of the functional layer in the absence of pregnancy. The biology of the endometrium relies on paracrine interactions between epithelial and stromal cells involving complex signaling pathways that are modulated by the variations of estrogen and progesterone levels across the menstrual cycle. Understanding the complexity of estrogen and progesterone receptor signaling will help elucidate the mechanisms underlying normal reproductive physiology and provide fundamental knowledge contributing to a better understanding of the consequences of hormonal imbalances on gynecological conditions and tumorigenesis. In this narrative review, we delve into the physiology of the endometrium, encompassing the complex signaling pathways of estrogen and progesterone.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Dias Da Silva, Isabelle ;  Université de Liège - ULiège > GIGA
Wuidar, Vincent ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Zielonka, Manon ;  Université de Liège - ULiège > GIGA > GIGA Cancer - Tumours and development biology
Pequeux, Christel  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques
Language :
English
Title :
Unraveling the Dynamics of Estrogen and Progesterone Signaling in the Endometrium: An Overview
Publication date :
23 July 2024
Journal title :
Cells
eISSN :
2073-4409
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Basel, Switzerland
Volume :
13
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 03 September 2024

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