Reference : Class IIa histone deacetylases: regulating the regulators.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Class IIa histone deacetylases: regulating the regulators.
Martin, Maud mailto [Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
Kettmann, Richard [Université de Liège - ULiège > > Gembloux Agro-Bio Tech >]
Dequiedt, Franck mailto [Université de Liège - ULiège > > Gembloux Agro-Bio Tech et GIGA Research > >]
Yes (verified by ORBi)
[en] HDAC ; Acetylation ; development ; chromatin ; transcription
[en] n the last decade, the identification of enzymes that regulate acetylation of histones and nonhistone proteins has revealed the key role of dynamic acetylation and deacetylation in various cellular processes. Mammalian histone deacetylases (HDACs), which catalyse the removal of acetyl groups from lysine residues, are grouped into three classes, on the basis of similarity to yeast counterparts. An abundance of experimental evidence has established class IIa HDACs as crucial transcriptional regulators of various developmental and differentiation processes. In the past 5 years, a tremendous effort has been dedicated to characterizing the regulation of these enzymes. In this review, we summarize the latest discoveries in the field and discuss the molecular and structural determinants of class IIa HDACs regulation. Finally, we emphasize that comprehension of the mechanisms underlying class IIa HDAC functions is essential for potential therapeutic applications.

File(s) associated to this reference

Fulltext file(s):

Restricted access
review oncogene 2007.pdfPublisher postprint259.98 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.