Class IIa histone deacetylases: regulating the regulators.

[en] n the last decade, the identification of enzymes that regulate acetylation of histones and nonhistone proteins has revealed the key role of dynamic acetylation and deacetylation in various cellular processes. Mammalian histone deacetylases (HDACs), which catalyse the removal of acetyl groups from lysine residues, are grouped into three classes, on the basis of similarity to yeast counterparts. An abundance of experimental evidence has established class IIa HDACs as crucial transcriptional regulators of various developmental and differentiation processes. In the past 5 years, a tremendous effort has been dedicated to characterizing the regulation of these enzymes. In this review, we summarize the latest discoveries in the field and discuss the molecular and structural determinants of class IIa HDACs regulation. Finally, we emphasize that comprehension of the mechanisms underlying class IIa HDAC functions is essential for potential therapeutic applications.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Martin, Maud ; Université de Liège - ULiège > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech

Kettmann, Richard ; Université de Liège - ULiège > Gembloux Agro-Bio Tech

Dequiedt, Franck ; Université de Liège - ULiège > Gembloux Agro-Bio Tech et GIGA Research

Language :

English

Title :

Class IIa histone deacetylases: regulating the regulators.

Publication date :

2007

Journal title :

Oncogene

ISSN :

0950-9232

eISSN :

1476-5594

Publisher :

Nature Publishing Group, United Kingdom

Volume :

Issue :

Pages :

5450-67

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 07 December 2009

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205

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