[en] [en] BACKGROUND AND OBJECTIVES: Genetic variability in the dopaminergic system could contribute to age-related impairments in executive control. In this study, we examined whether genetic polymorphism for catechol-O-methyltransferase (COMT Val158Met) is related to performance on updating, shifting and inhibition tasks.
METHODS: We administered a battery of executive tasks assessing updating, shifting and inhibition functions to 45 older and 55 younger healthy participants, and created composite z-scores associated to each function. Six groups were created based on genetic alleles (Val/Val, Val/Met, Met/Met) derived from the COMT gene and age (younger, older). Age and genotype effects were assessed with t-test and ANOVA (p<0.05).
RESULTS: A lower performance was observed in the older group for the three executive processes, and more particularly for inhibition. Moreover, older participants homozygous for the Val allele have a lower performance on the inhibition composite in comparison to younger Val/Val.
CONCLUSIONS: These results confirm presence of executive performance decrease in healthy aging. With regard to genetic effect, older participants seem particularly disadvantaged when they have a lower baseline dopamine level (i.e., Val/Val homozygous) that is magnified by aging, and when the executive measure emphasize the need of stable representations (as in inhibition task requiring to maintain active the instruction to not perform an automated process).
Disciplines :
Neurosciences & behavior
Author, co-author :
Apa, Zoltan ; Université de Liège - ULiège > Psychologie et Neuroscience Cognitives (PsyNCog) ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Gilsoul, Jessica ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory ; Université de Liège - ULiège > Psychologie et Neuroscience Cognitives (PsyNCog) > Cognition et Langage
Dideberg, Vinciane ; Université de Liège - ULiège > Département des sciences cliniques
Collette, Fabienne ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Language :
English
Title :
Association between executive functions and COMT Val108/158Met polymorphism among healthy younger and older adults: A preliminary study.
The Dataset includes behavioral data from 100 participants (55 younger and 45 older). The data were used in a study examining whether genetic polymorphism for catechol-O-methyltransferase (COMT Val158Met) is related to performance on updating, shifting and inhibition tasks during aging. The Dataset is made available to comply with FAIR principles. (2024-03-22)
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Crawford JR, Bryan J, Luszcz MA, Obonsawin MC, Stewart L. The Executive Decline Hypothesis of Cognitive Aging: Do Executive Deficits Qualify as Differential Deficits and Do They Mediate Age-Related Memory Decline? Aging Neuropsychol Cogn. 2000 Mar; 7(1):9–31.
Salthouse TA, Atkinson TM, Berish DE. Executive Functioning as a Potential Mediator of Age-Related Cognitive Decline in Normal Adults. J Exp Psychol Gen. 2003; 132(4):566–94. https://doi.org/10.1037/0096-3445.132.4.566 PMID: 14640849
Collette F, Salmon E. Les modifications du fonctionnement exécutif dans le vieillissement normal. Psychol Fr. 2014 Mar; 59(1):41–58.
Miyake A, Friedman NP, Emerson MJ, Witzki AH, Howerter A, Wager TD. The Unity and Diversity of Executive Functions and Their Contributions to Complex “Frontal Lobe” Tasks: A Latent Variable Analysis. Cognit Psychol. 2000 Aug; 41(1):49–100. https://doi.org/10.1006/cogp.1999.0734 PMID: 10945922
Verhaeghen P, Cerella J. Aging, executive control, and attention: a review of meta-analyses. Neurosci Biobehav Rev. 2002 Nov; 26(7):849–57. https://doi.org/10.1016/s0149-7634(02)00071-4 PMID: 12470697
Wasylyshyn C, Verhaeghen P, Sliwinski MJ. Aging and task switching: A meta-analysis. Psychol Aging. 2011; 26(1):15–20. https://doi.org/10.1037/a0020912 PMID: 21261411
Andrés P, Guerrini C, Phillips LH, Perfect TJ. Differential Effects of Aging on Executive and Automatic Inhibition. Dev Neuropsychol. 2008 Mar 6; 33(2):101–23. https://doi.org/10.1080/ 87565640701884212 PMID: 18443972
Collette F, Germain S, Hogge M, Van der Linden M. Inhibitory control of memory in normal ageing: Dissociation between impaired intentional and preserved unintentional processes. Memory. 2009 Jan; 17 (1):104–22. https://doi.org/10.1080/09658210802574146 PMID: 19105088
Collette F, Schmidt C, Scherrer C, Adam S, Salmon E. Specificity of inhibitory deficits in normal aging and Alzheimer’s disease. Neurobiol Aging. 2009 Jun; 30(6):875–89. https://doi.org/10.1016/j.neurobiolaging.2007.09.007 PMID: 18029058
Hogge M, Salmon E, Collette F. Interference and Negative Priming in Normal Aging and in Mild Alzheimer’s Disease. Psychol Belg. 2008 Jan 1; 48(1):1.
Dennis N, Cabeza R. Neuroimaging of Healthy Cognitive Aging. Fundam Informaticae—FUIN. 2008 Jan 1; 3.
Park DC, Reuter-Lorenz P. The Adaptive Brain: Aging and Neurocognitive Scaffolding. Annu Rev Psychol. 2009 Jan 1; 60(1):173–96. https://doi.org/10.1146/annurev.psych.59.103006.093656 PMID: 19035823
Manard M, Bahri MA, Salmon E, Collette F. Relationship between grey matter integrity and executive abilities in aging. Brain Res. 2016 Jul; 1642:562–80. https://doi.org/10.1016/j.brainres.2016.04.045 PMID: 27107940
Head D, Kennedy KM, Rodrigue KM, Raz N. Age differences in perseveration: Cognitive and neuroanatomical mediators of performance on the Wisconsin Card Sorting Test. Neuropsychologia. 2009 Mar; 47(4):1200–3. https://doi.org/10.1016/j.neuropsychologia.2009.01.003 PMID: 19166863
Mattay Venkata S, Fera F, Tessitore A, Hariri AR, Berman KF, Das S, et al. Neurophysiological correlates of age-related changes in working memory capacity. Neurosci Lett. 2006 Jan; 392(1–2):32–7. https://doi.org/10.1016/j.neulet.2005.09.025 PMID: 16213083
Ding X, Barban N, Tropf FC, Mills MC. The relationship between cognitive decline and a genetic predictor of educational attainment. Soc Sci Med. 2019 Oct; 239:112549. https://doi.org/10.1016/j.socscimed.2019.112549 PMID: 31546143
Xu Y, Yan J, Zhou P, Li J, Gao H, Xia Y, et al. Neurotransmitter receptors and cognitive dysfunction in Alzheimer’s disease and Parkinson’s disease. Prog Neurobiol. 2012 Apr; 97(1):1–13. https://doi.org/10.1016/j.pneurobio.2012.02.002 PMID: 22387368
Bäckman L, Nyberg L, Lindenberger U, Li SC, Farde L. The correlative triad among aging, dopamine, and cognition: Current status and future prospects. Neurosci Biobehav Rev. 2006 Jan; 30(6):791–807. https://doi.org/10.1016/j.neubiorev.2006.06.005 PMID: 16901542
Volkow ND, Fowler JS, Wang GJ, Baler R, Telang F. Imaging dopamine’s role in drug abuse and addiction. Neuropharmacology. 2009 Jan; 56:3–8. https://doi.org/10.1016/j.neuropharm.2008.05.022 PMID: 18617195
Karoum F, Chrapusta SJ, Egan MF. 3-Methoxytyramine Is the Major Metabolite of Released Dopamine in the Rat Frontal Cortex: Reassessment of the Effects of Antipsychotics on the Dynamics of Dopamine Release and Metabolism in the Frontal Cortex, Nucleus Accumbens, and Striatum by a Simple Two Pool Model. J Neurochem. 1994 Feb 2; 63(3):972–9. https://doi.org/10.1046/j.1471-4159.1994.63030972.x PMID: 7914228
Nieoullon A. Dopamine and the regulation of cognition and attention. Prog Neurobiol. 2002 May; 67 (1):53–83. https://doi.org/10.1016/s0301-0082(02)00011-4 PMID: 12126656
Ott T, Nieder A. Dopamine and Cognitive Control in Prefrontal Cortex. Trends Cogn Sci. 2019 Mar; 23 (3):213–34. https://doi.org/10.1016/j.tics.2018.12.006 PMID: 30711326
Khanthiyong B, Thanoi S, Reynolds GP, Nudmamud-Thanoi S. Association study of the functional Catechol-O-Methyltranferase (COMT) Val158Met polymorphism on executive cognitive function in a Thai sample. Int J Med Sci. 2019 Sep 20; 16(11):1461–5. https://doi.org/10.7150/ijms.35789 PMID: 31673237
Cools R, D’Esposito M. Inverted-U–shaped dopamine actions on human working memory and cognitive control. Biol Psychiatry. 2011 Jun; 69(12):e113–25. https://doi.org/10.1016/j.biopsych.2011.03. 028 PMID: 21531388
Cools R, Robbins TW. Chemistry of the adaptive mind. Thompson JMT, editor. Philos Trans R Soc Lond Ser Math Phys Eng Sci. 2004 Dec 15; 362(1825):2871–88. https://doi.org/10.1098/rsta.2004. 1468 PMID: 15539374
Goldman-Rakic P. D1 receptors in prefrontal cells and circuits. Brain Res Rev. 2000 Mar; 31(2–3):295–301. https://doi.org/10.1016/s0165-0173(99)00045-4 PMID: 10719156
Grossman MH, Emanuel BS, Budarf ML. Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1!q11.2. Genomics. 1992 Apr; 12(4):822–5. https://doi.org/10.1016/ 0888-7543(92)90316-k PMID: 1572656
Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders: Pharmacogenetics. 1996 Jun; 6(3):243–50.
Männistö PT, Kaakkola S. Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev. 1999 Dec; 51(4):593–628. PMID: 10581325
Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S, et al. Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain. Am J Hum Genet. 2004 Nov; 75(5):807–21. https://doi.org/10.1086/ 425589 PMID: 15457404
Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melen K, Julkunen I, et al. Kinetics of Human Soluble and Membrane-Bound Catechol O-Methyltransferase: A Revised Mechanism and Description of the Thermolabile Variant of the Enzyme. Biochemistry. 1995 Apr 4; 34(13):4202–10. https://doi.org/10.1021/ bi00013a008 PMID: 7703232
Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, et al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci. 2001 Jun 5; 98(12):6917–22. https://doi.org/10.1073/pnas.111134598 PMID: 11381111
Mattay VS, Goldberg TE, Fera F, Hariri AR, Tessitore A, Egan MF, et al. Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci. 2003 May 13; 100(10):6186–91. https://doi.org/10.1073/pnas.0931309100 PMID: 12716966
Rosa EC, Dickinson D, Apud J, Weinberger DR, Elvevåg B. COMT Val158Met polymorphism, cognitive stability and cognitive flexibility: an experimental examination. Behav Brain Funct. 2010; 6(1):53. https://doi.org/10.1186/1744-9081-6-53 PMID: 20836853
Stefanis NC, van Os J, Avramopoulos D, Smyrnis N, Evdokimidis I, Stefanis CN. Effect of COMT Val 158 Met Polymorphism on the Continuous Performance Test, Identical Pairs Version: Tuning Rather Than Improving Performance. Am J Psychiatry. 2005 Sep; 162(9):1752–4.
Barnett JH, Scoriels L, Munafò MR. Meta-Analysis of the Cognitive Effects of the Catechol-O-Methyltransferase Gene Val158/108Met Polymorphism. Biol Psychiatry. 2008 Jul; 64(2):137–44. https://doi.org/10.1016/j.biopsych.2008.01.005 PMID: 18339359
Blanchard MM, Chamberlain SR, Roiser J, Robbins TW, Müller U. Effects of two dopamine-modulating genes (DAT1 9/10 and COMT Val/Met) on n-back working memory performance in healthy volunteers. Psychol Med. 2011 Mar; 41(3):611–8.
Degen C, Zschocke J, Toro P, Sattler C, Wahl HW, Schönknecht P, et al. The COMTp.Val158Met Polymorphism and Cognitive Performance in Adult Development, Healthy Aging and Mild Cognitive Impairment. Dement Geriatr Cogn Disord. 2016; 41(1–2):27–34.
Ihne JL, Gallagher NM, Sullivan M, Callicott JH, Green AE. Is less really more: Does a prefrontal efficiency genotype actually confer better performance when working memory becomes difficult? Cortex. 2016 Jan; 74:79–95. https://doi.org/10.1016/j.cortex.2015.10.025 PMID: 26649915
Wardle MC, de Wit H, Penton-Voak I, Lewis G, Munafò MR. Lack of Association Between COMT and Working Memory in a Population-Based Cohort of Healthy Young Adults. Neuropsychopharmacology. 2013 Jun; 38(7):1253–63. https://doi.org/10.1038/npp.2013.24 PMID: 23337869
Colzato LS, Waszak F, Nieuwenhuis S, Posthuma D, Hommel B. The flexible mind is associated with the catechol-O-methyltransferase (COMT) Val158Met polymorphism: Evidence for a role of dopamine in the control of task-switching. Neuropsychologia. 2010 Jul; 48(9):2764–8. https://doi.org/10.1016/j.neuropsychologia.2010.04.023 PMID: 20434465
Krugel LK, Biele G, Mohr PNC, Li SC, Heekeren HR. Genetic variation in dopaminergic neuromodulation influences the ability to rapidly and flexibly adapt decisions. Proc Natl Acad Sci. 2009 Oct 20; 106 (42):17951–6. https://doi.org/10.1073/pnas.0905191106 PMID: 19822738
Wang Y, Li J, Chen C, Chen C, Zhu B, Moysis RK, et al. COMT rs4680 Met is not always the ‘smart allele’: Val allele is associated with better working memory and larger hippocampal volume in healthy Chinese: COMT rs4680 Met is not always the ‘smart allele.’ Genes Brain Behav. 2013 Apr; 12(3):323–9.
Weiss EM, Schulter G, Fink A, Reiser EM, Mittenecker E, Niederstätter H, et al. Influences of COMT and 5-HTTLPR Polymorphisms on Cognitive Flexibility in Healthy Women: Inhibition of Prepotent Responses and Memory Updating. Homberg J, editor. PLoS ONE. 2014 Jan 20; 9(1):e85506. https://doi.org/10.1371/journal.pone.0085506 PMID: 24465579
Bilder RM, Volavka J, Lachman HM, Grace AA. The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes. Neuropsychopharmacology. 2004 Nov; 29(11):1943–61. https://doi.org/10.1038/sj.npp.1300542 PMID: 15305167
Nagel IE. Human aging magnifies genetic effects on executive functioning and working memory. Front Hum Neurosci [Internet]. 2008 [cited 2018 Dec 5]; 2. Available from: http://journal.frontiersin.org/article/10.3389/neuro.09.001.2008/abstract. https://doi.org/10.3389/neuro.09.001.2008 PMID: 18958202
Nyberg L, Andersson M, Kauppi K, Lundquist A, Persson J, Pudas S, et al. Age-related and Genetic Modulation of Frontal Cortex Efficiency. J Cogn Neurosci. 2014 Apr; 26(4):746–54. https://doi.org/10.1162/jocn_a_00521 PMID: 24236764
Sambataro F, Reed JD, Murty VP, Das S, Tan HY, Callicott JH, et al. Catechol-O-Methyltransferase Valine158Methionine Polymorphism Modulates Brain Networks Underlying Working Memory Across Adulthood. Biol Psychiatry. 2009 Sep; 66(6):540–8. https://doi.org/10.1016/j.biopsych.2009.04.014 PMID: 19539269
Bruder GE, Keilp JG, Xu H, Shikhman M, Schori E, Gorman JM, et al. Catechol-O-Methyltransferase (COMT) Genotypes and Working Memory: Associations with Differing Cognitive Operations. Biol Psychiatry. 2005 Dec; 58(11):901–7. https://doi.org/10.1016/j.biopsych.2005.05.010 PMID: 16043133
Heim AF, Coyne MJ, Kamboh MI, Ryan C, Jennings JR. The catechol-o-methyltransferase Val158Met polymorphism modulates organization of regional cerebral blood flow response to working memory in adults. Int J Psychophysiol. 2013 Nov; 90(2):149–56. https://doi.org/10.1016/j.ijpsycho.2013.06.023 PMID: 23810996
O’Hara R, Miller E, Liao CP, Way N, Lin X, Hallmayer J. COMT genotype, gender and cognition in community-dwelling, older adults. Neurosci Lett. 2006 Dec; 409(3):205–9. https://doi.org/10.1016/j.neulet.2006.09.047 PMID: 17029783
Potter GG, Taylor WD, McQuoid DR, Steffens DC, Welsh-Bohmer KA, Krishnan KRR. The COMT Val158Met polymorphism and cognition in depressed and nondepressed older adults. Int J Geriatr Psychiatry. 2009 Oct; 24(10):1127–33. https://doi.org/10.1002/gps.2235 PMID: 19296553
Bellander M, Bäckman L, Liu T, Schjeide BMM, Bertram L, Schmiedek F, et al. Lower baseline performance but greater plasticity of working memory for carriers of the val allele of the COMT Val158Met polymorphism. Neuropsychology. 2015 Mar; 29(2):247–54.
Fiocco AJ, Lindquist K, Ferrell R, Li R, Simonsick EM, Nalls M, et al. COMT genotype and cognitive function: An 8-year longitudinal study in white and black elders. Neurology. 2010 Apr 20; 74(16):1296–302. https://doi.org/10.1212/WNL.0b013e3181d9edba PMID: 20404311
Solís-Ortiz S, Pérez-Luque E, Morado-Crespo L, Gutiérrez-Muñoz M. Executive functions and selective attention are favored in middle-aged healthy women carriers of the Val/Val genotype of the catechol-o-methyltransferase gene: a behavioral genetic study. Behav Brain Funct. 2010; 6(1):67. https://doi.org/10.1186/1744-9081-6-67 PMID: 21029471
Mattis S. Mental Status Examination for Organic Mental Syndrome in the Elderly Patient. In: Geriatric Psychiatry. In: Bellack L. and Karusu T.B., Eds.,. New York: Grune & Stratton; 1976. p. 77–121.
Monsch AU. Clinical Validity of the Mattis Dementia Rating Scale in Detecting Dementia of the Alzheimer Type: A Double Cross-Validation and Application to a Community-Dwelling Sample. Arch Neurol. 1995 Sep 1; 52(9):899.
Reuter M, Peters K, Schroeter K, Koebke W, Lenardon D, Bloch B, et al. The influence of the dopaminergic system on cognitive functioning: A molecular genetic approach. Behav Brain Res. 2005 Oct; 164(1):93–9. https://doi.org/10.1016/j.bbr.2005.06.002 PMID: 16026865
Raven JC. Advanced Progressive Matrices. Sets I and II. London: HK Lewis & Co. San Antonio, Texas; 1965.
Deltour JJ. Echelle de vocabulaire Mill Hill de JC Raven: Adaptation française et normes comparées du Mill Hill et du Standard Progressive Matrices (PM38). Man Annex Braine Château Belg Appl Tech Mod. 1993;
Sorel O. Approche développementale du raisonnement bayésien: analyse quantitative et qualitative selon le format de présentation et le niveau scolaire. Doctoral Dissertation, University of Tours, France. 2009.
Stroop JR. Studies of interference in serial verbal reactions. J Exp Psychol. 1935; 18(6):643–62.
Kirchner WK. Age differences in short-term retention of rapidly changing information. J Exp Psychol. 1958; 55(4):352–8. https://doi.org/10.1037/h0043688 PMID: 13539317
Spector A, Biederman I. Mental Set and Mental Shift Revisited. Am J Psychol. 1976 Dec; 89(4):669.
Cardebat D, Doyon B, Puel M, Goulet P, Joanette Y. [Formal and semantic lexical evocation in normal subjects. Performance and dynamics of production as a function of sex, age and educational level]. Acta Neurol Belg. 1990; 90(4):207–17.
Eslinger PJ, Grattan LM. Frontal lobe and frontal-striatal substrates for different forms of human cognitive flexibility. Neuropsychologia. 1993 Jan; 31(1):17–28. https://doi.org/10.1016/0028-3932(93) 90077-d PMID: 8437679
Nutterupham K, Saykin A, Rabin L, Roth R, Wishart H, Pare N, et al. Verbal fluency performance in amnestic MCI and older adults with cognitive complaints. Arch Clin Neuropsychol. 2008 May; 23 (3):229–41. https://doi.org/10.1016/j.acn.2008.01.005 PMID: 18339515
Troyer AK, Moscovitch M, Winocur G. Clustering and switching as two components of verbal fluency: Evidence from younger and older healthy adults. Neuropsychology. 1997; 11(1):138–46. https://doi.org/10.1037//0894-4105.11.1.138 PMID: 9055277
Steinmetz JP, Houssemand C. What About Inhibition in the Wisconsin Card Sorting Test? Clin Neuropsychol. 2011 May; 25(4):652–69. https://doi.org/10.1080/13854046.2011.568525 PMID: 21547856
Friedman NP, Miyake A. The Relations Among Inhibition and Interference Control Functions: A Latent-Variable Analysis. J Exp Psychol Gen. 2004 Mar; 133(1):101–35. https://doi.org/10.1037/00963445.133.1.101 PMID: 14979754
Peters M, Giesbrecht T, Jelicic M, Merckelbach H. The random number generation task: Psychometric properties and normative data of an executive function task in a mixed sample. J Int Neuropsychol Soc [Internet]. 2007 Jul [cited 2021 May 27]; 13(04). Available from: http://www.journals.cambridge.org/ abstract_S1355617707070786.
Towse JN, Neil D. Analyzing human random generation behavior: A review of methods used and a computer program for describing performance. Behav Res Methods Instrum Comput. 1998 Dec; 30 (4):583–91.
Keefe R. The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery. Schizophr Res. 2004 Jun 1; 68(2–3):283–97. https://doi.org/10.1016/j.schres.2003.09.011 PMID: 15099610
Jacob Cohen. Statistical Power Analysis for the Behavioral Sciences. Cohen J. (1988). Hillside, NJ: Lawrence Erlbaum Associates; 1998.
McDonald AP, D’Arcy RCN, Song X. Functional MRI on executive functioning in aging and dementia: A scoping review of cognitive tasks. Aging Med. 2018 Sep; 1(2):209–19. https://doi.org/10.1002/agm2.12037 PMID: 31942499
Lehto J. Are Executive Function Tests Dependent on Working Memory Capacity? Q J Exp Psychol Sect A. 1996 Feb; 49(1):29–50.
Rabbitt P, editor. Methodology Of Frontal And Executive Function [Internet]. 0 ed. Routledge; 2004 [cited 2022 Sep 21]. Available from: https://www.taylorfrancis.com/books/9781135472030.
Robbins TW, James M, Owen AM, Sahakian BJ, Lawrence AD, Mcinnes L, et al. A study of performance on tests from the CANTAB battery sensitive to frontal lobe dysfunction in a large sample of normal volunteers: Implications for theories of executive functioning and cognitive aging. J Int Neuropsychol Soc [Internet]. 1998 Sep [cited 2022 Sep 21]; 4(05). Available from: http://www.journals.cambridge.org/abstract_S1355617798455073.
Gilsoul J, Simon J, Hogge M, Collette F. Do attentional capacities and processing speed mediate the effect of age on executive functioning? Aging Neuropsychol Cogn. 2019 Mar 4; 26(2):282–317. https://doi.org/10.1080/13825585.2018.1432746 PMID: 29405831
Andres P, Van der Linden M. Age-Related Differences in Supervisory Attentional System Functions. J Gerontol B Psychol Sci Soc Sci. 2000 Nov 1; 55(6):P373–80. https://doi.org/10.1093/geronb/55.6. p373 PMID: 11078107
Dueker N, Wang L, Gardener H, Gomez L, Kaur S, Beecham A, et al. Genome-wide association study of executive function in a multi-ethnic cohort implicates LINC01362: Results from the northern Manhattan study. Neurobiol Aging. 2023 Mar; 123:216–21. https://doi.org/10.1016/j.neurobiolaging.2022.11. 016 PMID: 36658081
Hatoum AS, Morrison CL, Mitchell EC, Lam M, Benca-Bachman CE, Reineberg AE, et al. Genome-wide Association Study Shows That Executive Functioning Is Influenced by GABAergic Processes and Is a Neurocognitive Genetic Correlate of Psychiatric Disorders. Biol Psychiatry. 2023 Jan; 93 (1):59–70. https://doi.org/10.1016/j.biopsych.2022.06.034 PMID: 36150907
Goldberg TE, Egan MF, Gscheidle T, Coppola R, Weickert T, Kolachana BS, et al. Executive Subprocesses in Working Memory: Relationship to Catechol- O -methyltransferase Val158Met Genotype and Schizophrenia. Arch Gen Psychiatry. 2003 Sep 1; 60(9):889.
Malhotra AK, Kestler LJ, Mazzanti C, Bates JA, Goldberg T, Goldman D. A Functional Polymorphism in the COMT Gene and Performance on a Test of Prefrontal Cognition. Am J Psychiatry. 2002 Apr; 159(4):652–4. https://doi.org/10.1176/appi.ajp.159.4.652 PMID: 11925305
Joober Ridha, Boksa Patricia, Benkelfat Chawki, Rouleau Guy. Genetics of schizophrenia: from animal models to clinical studies. J Psychiatry Neurosci. 2002 Jun 11; 27(5):336–47. PMID: 12271789
Bertolino A. Additive Effects of Genetic Variation in Dopamine Regulating Genes on Working Memory Cortical Activity in Human Brain. J Neurosci. 2006 Apr 12; 26(15):3918–22. https://doi.org/10.1523/JNEUROSCI.4975-05.2006 PMID: 16611807
Jaspar M. The impact of dopaminergic genes on inhibitory processes and cognitive control [Internet]. Poster presented at: British Neuropsychological Society with la Société de Neuropsychologie de Langue Française; 2016 Mar 18; London United kingdom. Available from: https://orbi.uliege.be/handle/2268/201342.
Barnes JJM, Dean AJ, Nandam LS, O’Connell RG, Bellgrove MA. The Molecular Genetics of Executive Function: Role of Monoamine System Genes. Biol Psychiatry. 2011 Jun; 69(12):e127–43. https://doi.org/10.1016/j.biopsych.2010.12.040 PMID: 21397212
Harris SE, Wright AF, Hayward C, Starr JM, Whalley LJ, Deary IJ. The functional COMT polymorphism, Val158Met, is associated with logical memory and the personality trait intellect/imagination in a cohort of healthy 79 year olds. Neurosci Lett. 2005 Sep; 385(1):1–6. https://doi.org/10.1016/j.neulet.2005.04.104 PMID: 15979789
Starr JM, Fox H, Harris SE, Deary IJ, Whalley LJ. COMT genotype and cognitive ability: A longitudinal aging study. Neurosci Lett. 2007 Jun; 421(1):57–61. https://doi.org/10.1016/j.neulet.2007.05.023 PMID: 17548151
de Frias CM, Annerbrink K, Westberg L, Eriksson E, Adolfsson R, Nilsson LG. COMT Gene Polymorphism Is Associated with Declarative Memory in Adulthood and Old Age. Behav Genet. 2004 Sep 1; 34(5):533–9. https://doi.org/10.1023/B:BEGE.0000038491.06972.8c PMID: 15319576
Erickson KI. Genetic contributions to age-related decline in executive function: a 10-year longitudinal study of COMT and BDNF polymorphisms. Front Hum Neurosci [Internet]. 2008 [cited 2022 Nov 3]; 2. Available from: http://journal.frontiersin.org/article/10.3389/neuro.09.011.2008/abstract. https://doi.org/10.3389/neuro.09.011.2008 PMID: 18958211
Sapkota S, Vergote D, Westaway D, Jhamandas J, Dixon RA. Synergistic associations of catechol-O-methyltransferase and brain-derived neurotrophic factor with executive function in aging are selective and modified by apolipoprotein E. Neurobiol Aging. 2015 Jan; 36(1):249–56. https://doi.org/10.1016/j.neurobiolaging.2014.06.020 PMID: 25107496
Sapkota S, Bäckman L, Dixon RA. Executive function performance and change in aging is predicted by apolipoprotein E, intensified by catechol-O-methyltransferase and brain-derived neurotrophic factor, and moderated by age and lifestyle. Neurobiol Aging. 2017 Apr; 52:81–9. https://doi.org/10.1016/j.neurobiolaging.2016.12.022 PMID: 28131014
Pizzonia KL, Suhr JA, Clark LA, Clark BC. The relation of ApoE and COMT gene–gene interactions to cognitive and motor function in community-dwelling older adults: a pilot study. Front Aging Neurosci. 2023 Aug 31; 15:1206473. https://doi.org/10.3389/fnagi.2023.1206473 PMID: 37744392
Durstewitz D, Seamans JK. The Dual-State Theory of Prefrontal Cortex Dopamine Function with Relevance to Catechol-O-Methyltransferase Genotypes and Schizophrenia. Biol Psychiatry. 2008 Nov; 64 (9):739–49. https://doi.org/10.1016/j.biopsych.2008.05.015 PMID: 18620336
Ettinger U, Kumari V, Collier DA, Powell J, Luzi S, Michel TM, et al. Catechol-O-Methyltransferase (COMT) Val158Met Genotype is Associated with BOLD Response as a Function of Task Characteristic. Neuropsychopharmacology. 2008 Dec; 33(13):3046–57. https://doi.org/10.1038/sj.npp.1301658 PMID: 18235427
Nolan KA, Bilder RM, Lachman HM, Volavka J. Catechol O -Methyltransferase Val 158 Met Polymorphism in Schizophrenia: Differential Effects of Val and Met Alleles on Cognitive Stability and Flexibility. Am J Psychiatry. 2004 Feb; 161(2):359–61.
Hasher L, Zacks R, May C. Inhibitory control, circadian arousal and age. In: Attention and Performance. 1999. p. 653–75.
de Frias CM, Marklund P, Eriksson E, Larsson A, Oman L, Annerbrink K, et al. Bäckman. Influence of COMT gene polymorphism on fMRI-assessed sustained and transient activity during a working memory task. J Cogn Neurosci. 2010 Jul; 22(7):1614–22.
Morris KA, Grace SA, Woods W, Dean B, Rossell SL. The influence of COMT rs4680 on functional connectivity in healthy adults: A systematic review. Eur J Neurosci. 2020 Oct; 52(8):3851–78. https://doi.org/10.1111/ejn.14748 PMID: 32306439
Liu ME, Hong CJ, Liou YJ, Tsai YL, Hsieh CH, Tsai SJ. Association study of a functional catechol-O-methyltransferase polymorphism and executive function in elderly males without dementia. Neurosci Lett. 2008 May; 436(2):193–5. https://doi.org/10.1016/j.neulet.2008.03.018 PMID: 18387741
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.