Journey of monocytes and macrophages upon influenza A virus infection

[en] Influenza A virus (IAV) infections pose a global health challenge that necessitates a comprehensive understanding of the host immune response to devise effective therapeutic interventions. As monocytes and macrophages play crucial roles in host defence, inflammation, and repair, this review explores the intricate journey of these cells during and after IAV infection. First, we highlight the dynamics and functions of lung-resident macrophage populations post-IAV. Second, we review the current knowledge of recruited monocytes and monocyte-derived cells, emphasising their roles in viral clearance, inflammation, immunomodulation, and tissue repair. Third, we shed light on the consequences of IAV-induced macrophage alterations on long-term lung immunity. We conclude by underscoring current knowledge gaps and exciting prospects for future research in unravelling the complexities of macrophage responses to respiratory viral infections.

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology

Author, co-author :

Ruscitti, Cecilia ^✱; Université de Liège - ULiège > GIGA

Radermecker, Coraline ^✱; Université de Liège - ULiège > GIGA > GIGA I3 - Immunophysiology

Marichal, Thomas ^✱; Université de Liège - ULiège > GIGA > GIGA I3 - Immunophysiology

^✱ These authors have contributed equally to this work.

Language :

English

Title :

Journey of monocytes and macrophages upon influenza A virus infection

Publication date :

01 April 2024

Journal title :

Current Opinion in Virology

ISSN :

1879-6257

eISSN :

1879-6265

Publisher :

Elsevier B.V., Netherlands

Volume :

Pages :

101409

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S1879625724000233?httpAccept=text/xml

Funders :

Fonds Baillet Latour
F.R.S.-FNRS - Fonds de la Recherche Scientifique
WELBIO - Walloon Excellence in Life Sciences and Biotechnology
ERC - European Research Council

Available on ORBi :

since 22 April 2024

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