Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro.

Scuvée-Moreau, Jacqueline; Seutin, Vincent; Vrijens, Bernard; Pirotte, Bernard; De Tullio, Pascal; Massotte, Laurent; Albert, Adelin; Delarge, J; Dresse, Albert

doi:10.1076/apab.105.5.421.3285

Article (Scientific journals)

Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro.

Scuvée-Moreau, Jacqueline; Seutin, Vincent; Vrijens, Bernard et al.

1997 • In Archives of Physiology and Biochemistry, 105 (5), p. 421-8

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/31187

DOI
10.1076/apab.105.5.421.3285

PubMed
9439778

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Keywords :

Action Potentials/drug effects; Animals; Cromakalim/pharmacology; Diazoxide/pharmacology; Dopamine/metabolism; Guanidines/pharmacology; Hippocampus/cytology/drug effects/physiology; Male; Neurons/drug effects/physiology; Pinacidil; Potassium Channels/drug effects; Pyramidal Cells/drug effects/physiology; Pyridines/pharmacology; Rats; Rats, Wistar; Thiadiazines/pharmacology; Ventral Tegmental Area/cytology/drug effects/physiology

Abstract :

[en] The effect of four KATP channel openers (KCOs) on the firing rate of CA1 pyramidal cells and A10 dopaminergic neurons was investigated using extracellular recording techniques in rat brain slices. Pinacidil, lemakalim, diazoxide and a new compound, BPDZ44, had an inhibitory effect on the electrical activity of CA1 pyramidal cells. They all had a similar potency. Only BPDZ44 and diazoxide inhibited the firing rate of A10 dopamine neurons. The sulfonylurea glipizide (1 microM) antagonized the effect of BPDZ44 and diazoxide on A10 neurons but failed to antagonize the effect of KCOs on CA1 pyramidal cells. These results show that differences exist among KCOs in their ability to decrease the electrical activity of various populations of central neurons.

Disciplines :

General & internal medicine
Pharmacy, pharmacology & toxicology

Author, co-author :

Scuvée-Moreau, Jacqueline ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Pharmacologie - Département des sciences biomédicales et précliniques

Seutin, Vincent ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Pharmacologie

Vrijens, Bernard ; Université de Liège - ULiège > Département de mathématique > Département de mathématique

Pirotte, Bernard ; Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique

De Tullio, Pascal ; Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique

Massotte, Laurent ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Albert, Adelin ; Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique

Delarge, J

Dresse, Albert ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)

Language :

English

Title :

Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro.

Publication date :

1997

Journal title :

Archives of Physiology and Biochemistry

ISSN :

1381-3455

eISSN :

1744-4160

Publisher :

Taylor & Francis, Abingdon, United Kingdom

Volume :

105

Issue :

Pages :

421-8

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 02 December 2009

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