Multimodal imaging of microstructural cerebral alterations and loss of synaptic density in Alzheimer's disease.

Alzheimer’s disease; MTsat; Multivariate analysis; PET; Quantitative MRI; R2*; Total volume distribution; Iron; Male; Humans; Brain/diagnostic imaging; Brain/pathology; Magnetic Resonance Imaging/methods; Multimodal Imaging/methods; Atrophy/pathology; Alzheimer Disease/diagnostic imaging; Alzheimer Disease/pathology; Demyelinating Diseases; Atrophy; Brain; Magnetic Resonance Imaging; Multimodal Imaging; Neuroscience (all); Aging; Neurology (clinical); Developmental Biology; Geriatrics and Gerontology; General Neuroscience

Abstract :

[en] Multiple neuropathological events are involved in Alzheimer's disease (AD). The current study investigated the concurrence of neurodegeneration, increased iron content, atrophy, and demyelination in AD. Quantitative multiparameter magnetic resonance imaging (MRI) maps providing neuroimaging biomarkers for myelination and iron content along with synaptic density measurements using [18F] UCB-H PET were acquired in 24 AD and 19 Healthy controls (19 males). The whole brain voxel-wise group comparison revealed demyelination in the right hippocampus, while no significant iron content difference was detected. Bilateral atrophy and synaptic density loss were observed in the hippocampus and amygdala. The multivariate GLM (mGLM) analysis shows a bilateral difference in the hippocampus and amygdala, right pallidum, left fusiform and temporal lobe suggesting that these regions are the most affected despite the diverse differences in brain tissue properties in AD. Demyelination was identified as the most affecting factor in the observed differences. Here, the mGLM is introduced as an alternative for multiple comparisons between different modalities, reducing the risk of false positives while informing about the co-occurrence of neuropathological processes in AD.

Disciplines :

Human health sciences: Multidisciplinary, general & others

Author, co-author :

Moallemian, Soodeh ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory

Salmon, Eric ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory

Bahri, Mohamed Ali ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory

Beliy, Nikita ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory

Delhaye, Emma ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory

Balteau, Evelyne ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Neuroimaging, data acquisition and processing

Degueldre, Christian ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory

Phillips, Christophe ^✱; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Neuroimaging, data acquisition and processing

Bastin, Christine ^✱; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory

^✱ These authors have contributed equally to this work.

Language :

English

Title :

Multimodal imaging of microstructural cerebral alterations and loss of synaptic density in Alzheimer's disease.

Publication date :

December 2023

Journal title :

Neurobiology of Aging

ISSN :

0197-4580

eISSN :

1558-1497

Publisher :

Elsevier Inc., United States

Volume :

132

Pages :

24 - 35

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0197458023002002?httpAccept=text/xml

Funding text :

Funding: This work was supported by the ULiege Research Concerted Action (SLEEPDEM, grant 17/2109 ) and Walloon Region in the framework of the PIT program PROTHER-WAL under grant agreement No. 7289. [18F]flutemetamol was provided by GE Healthcare. CB is a Senior Research Associate at the F.R.S.-FNRS and CP is a Research Director at the F.R.S.-FNRS.Funding: This work was supported by the ULiege Research Concerted Action (SLEEPDEM, grant 17/2109) and Walloon Region in the framework of the PIT program PROTHER-WAL under grant agreement No. 7289. [18F]flutemetamol was provided by GE Healthcare. CB is a Senior Research Associate at the F.R.S.-FNRS and CP is a Research Director at the F.R.S.-FNRS.

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