Beware the Receptor Variants.

[en] The MAS-related genes (also known as MRGPRs) are a complex family of G protein-coupled receptors initially discovered in sensory neurons. Most of them are orphans, which means that they have no known validated endogenous ligands. Although MRGPRs bear great potential as drug targets, notably in itch and nociception, their study has been hampered by the scarcity or absence of potent and selective ligands, especially for the primate-specific MRGPRX subfamily.

Research center :

GIGA Molecular Biology of Diseases-Molecular Pharmacology - ULiège [BE]
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège [BE]

Disciplines :

Pharmacy, pharmacology & toxicology
Biochemistry, biophysics & molecular biology
Chemistry

Author, co-author :

Hanson, Julien ; Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique

Language :

English

Title :

Beware the Receptor Variants.

Publication date :

17 November 2023

Journal title :

Journal of Medicinal Chemistry

ISSN :

0022-2623

eISSN :

1520-4804

Publisher :

American Chemical Society (ACS), United States

Peer reviewed :

Editorial reviewed

Additional URL :

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02026

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]

Available on ORBi :

since 22 November 2023

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Bibliography

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