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Beware the Receptor Variants.
Hanson, Julien
2023In Journal of Medicinal Chemistry
Editorial reviewed
 

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Keywords :
Drug Discovery; Molecular Medicine
Abstract :
[en] The MAS-related genes (also known as MRGPRs) are a complex family of G protein-coupled receptors initially discovered in sensory neurons. Most of them are orphans, which means that they have no known validated endogenous ligands. Although MRGPRs bear great potential as drug targets, notably in itch and nociception, their study has been hampered by the scarcity or absence of potent and selective ligands, especially for the primate-specific MRGPRX subfamily.
Research center :
GIGA Molecular Biology of Diseases-Molecular Pharmacology - ULiège [BE]
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège [BE]
Disciplines :
Pharmacy, pharmacology & toxicology
Biochemistry, biophysics & molecular biology
Chemistry
Author, co-author :
Hanson, Julien  ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
Language :
English
Title :
Beware the Receptor Variants.
Publication date :
17 November 2023
Journal title :
Journal of Medicinal Chemistry
ISSN :
0022-2623
eISSN :
1520-4804
Publisher :
American Chemical Society (ACS), United States
Peer reviewed :
Editorial reviewed
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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since 22 November 2023

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