Article (Scientific journals)
An Empirical Model Linking Physico-Chemical Biomaterial Characteristics to Intra-Oral Bone Formation.
Sadeghian Dehkord, Ehsan; Kerckhofs, Greet; Compère, Philippe et al.
2023In Journal of Functional Biomaterials, 14 (7), p. 388
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Keywords :
biomaterials; calcium phosphate; empirical modeling; intra-oral bone formation; physico-chemical; Biomedical Engineering
Abstract :
[en] Facial trauma, bone resection due to cancer, periodontal diseases, and bone atrophy following tooth extraction often leads to alveolar bone defects that require bone regeneration in order to restore dental function. Guided bone regeneration using synthetic biomaterials has been suggested as an alternative approach to autologous bone grafts. The efficiency of bone substitute materials seems to be influenced by their physico-chemical characteristics; however, the debate is still ongoing on what constitutes optimal biomaterial characteristics. The purpose of this study was to develop an empirical model allowing the assessment of the bone regeneration potential of new biomaterials on the basis of their physico-chemical characteristics, potentially giving directions for the design of a new generation of dental biomaterials. A quantitative data set was built composed of physico-chemical characteristics of seven commercially available intra-oral bone biomaterials and their in vivo response. This empirical model allowed the identification of the construct parameters driving optimized bone formation. The presented model provides a better understanding of the influence of driving biomaterial properties in the bone healing process and can be used as a tool to design bone biomaterials with a more controlled and custom-made composition and structure, thereby facilitating and improving the clinical translation.
Research center :
d‐BRU - Dental Biomaterials Research Unit - ULiège [BE]
Disciplines :
Biotechnology
Author, co-author :
Sadeghian Dehkord, Ehsan  ;  Université de Liège - ULiège > GIGA ; Prometheus, Division for Skeletal Tissue Engineering, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
Kerckhofs, Greet  ;  Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique ; Prometheus, Division for Skeletal Tissue Engineering, Katholieke Universiteit Leuven, 3000 Leuven, Belgium ; Biomechanics Laboratory, Institute of Mechanics, Materials, and Civil Engineering (iMMC), Université Catholique Louvain, 1348 Louvain-la-Neuve, Belgium ; Institute of Experimental and Clinical Research (IREC), Université Catholique Louvain, 1200 Woluwé-Saint-Lambert, Belgium ; Department of Materials Engineering (MTM), Katholieke Universiteit Leuven, 3000 Leuven, Belgium
Compère, Philippe ;  Université de Liège - ULiège > Département de Biologie, Ecologie et Evolution
Lambert, France ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de parodontologie, chirurgie bucco-dentaire et chirurgie implantaire
Geris, Liesbet  ;  Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique ; Prometheus, Division for Skeletal Tissue Engineering, Katholieke Universiteit Leuven, 3000 Leuven, Belgium ; Department of Mechanical Engineering, Division of Biomechanics (BMe), Katholieke Universiteit Leuven, 3000 Leuven, Belgium
Language :
English
Title :
An Empirical Model Linking Physico-Chemical Biomaterial Characteristics to Intra-Oral Bone Formation.
Publication date :
22 July 2023
Journal title :
Journal of Functional Biomaterials
eISSN :
2079-4983
Publisher :
MDPI AG, Switzerland
Volume :
14
Issue :
7
Pages :
388
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
ERC - European Research Council [BE]
Walloon region [BE]
SPW EER - Service Public de Wallonie. Economie, Emploi, Recherche [BE]
Funding text :
The authors gratefully acknowledge funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement CoG 772418), BioWin project BIOPTOS (supported by Belgium’sWalloon Region) and B2Bone project (Regional FundingWin2Wal).
Available on ORBi :
since 23 September 2023

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